Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

(2014) Rebecca A Barnard et al.   Autophagy

Combined autophagy and HDAC inhibition

(2014) Devalingam Mahalingam et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

(2014) B. Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia

(2013) S. Katagiri et al.   CLINICAL CANCER RESEARCH

Autophagy in blood cancers: biological role and therapeutic implications

(2013) A. Nencioni et al.   HAEMATOLOGICA

Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells

(2013) Ying Wang et al.   HEPATOLOGY

Ever-advancing chronic myeloid leukemia treatment

(2013) Shinya Kimura et al.   International Journal of Clinical Oncology

Cleavage of BCR–ABL transcripts at the T315I point mutation by DNAzyme promotes apoptotic cell death in imatinib-resistant BCR–ABL leukemic cells

(2013) J E Kim et al.   LEUKEMIA

Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-β in Human Glioma Cells

(2013) Yubin Li et al.   MOLECULAR NEUROBIOLOGY

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Plays a Critical Role in ChLym-1-Induced Cytotoxicity of Non-Hodgkin’s Lymphoma Cells

(2013) Jiajun Fan et al.   PLoS One

Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin’s lymphoma cells

(2013) X Zeng et al.   Cell Death & Disease

Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells

(2013) Ahmad Hamad et al.   Stem Cells International

Sonic hedgehog promotes autophagy in hippocampal neurons

(2013) R. S. Petralia et al.   Biology Open

Sonic hedgehog promotes autophagy of vascular smooth muscle cells

(2012) Haijie Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function

(2012) Malene Ambjørn et al.   Autophagy

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

(2012) D. J. Goussetis et al.   BLOOD

Targeting hedgehog in hematologic malignancy

(2012) D. A. Irvine et al.   BLOOD

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

Hedgehog pathway inhibition and the race against tumor evolution

(2012) Scott X. Atwood et al.   JOURNAL OF CELL BIOLOGY

Tumor-Cell Death, Autophagy, and Immunity

(2012) Louis M. Weiner et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML

(2011) G. V. Helgason et al.   BLOOD

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The Role of Autophagy in Clinical Practice

(2011) A.L. Swampillai et al.   CLINICAL ONCOLOGY

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

(2011) B G Mar et al.   LEUKEMIA

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer

(2010) Fazlul H. Sarkar et al.   CANCER AND METASTASIS REVIEWS

Hedgehog pathway activation in chronic myeloid leukemia: A promise for a novel combination therapeutic approach?

(2010) Zainab Jagani et al.   CELL CYCLE

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

Activity of the potent dual Abl/Src tyrosine kinase inhibitor FB2 against Bcr–Abl positive cell lines in vitro and in vivo

(2010) Xia Yuan et al.   LEUKEMIA RESEARCH

Hedgehog signaling maintains chemoresistance in myeloid leukemic cells

(2010) K C S Queiroz et al.   ONCOGENE

Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

(2009) Masayoshi Kobune et al.   CANCER SCIENCE

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

(2009) Jie Gao et al.   Cell Stem Cell

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

(2009) Inga Hofmann et al.   Cell Stem Cell

Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation

(2009) X. Shi et al.   CLINICAL CANCER RESEARCH

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

(2009) Cristian Bellodi et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors

(2008) Yuko Mishima et al.   CANCER SCIENCE

The hedgehog inhibitor cyclopamine induces apoptosis in leukemic cellsin vitro

(2008) Jörg Warzecha et al.   LEUKEMIA & LYMPHOMA