Article
Pharmacology & Pharmacy
Rasool Haddadi, Mohammad Cheraghi-poor
Summary: This study investigated the analgesic and anti-inflammatory effects of naproxen and pioglitazone, and found that their combined treatment enhanced these effects. The involvement of PPAR-gamma receptor was also noted. Additionally, these drugs reduced the release of inflammatory cytokines and myeloperoxidase activity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Article
Pharmacology & Pharmacy
Maki Fujimoto, Hitoshi Higuchi, Yuka Honda-Wakasugi, Saki Miyake, Yukiko Nishioka, Akiko Yabuki-Kawase, Shigeru Maeda, Takuya Miyawaki
Summary: The study investigated the anti-inflammatory mechanism of dexmedetomidine in inhibiting LPS-induced inflammatory responses. It was found that dexmedetomidine inhibits inflammation by activating PPAR gamma or increasing the production of 15d-PGJ2. The results suggest that dexmedetomidine inhibits LPS-induced inflammatory responses by binding to alpha(2) adrenoceptors and activating PPAR gamma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen
Summary: Cyclooxygenases play a vital role in inflammation, but currently used anti-inflammatory drugs have associated adverse effects. Researchers are searching for novel selective COX-2 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Qirong Lu, Pu Guo, Jingchao Guo, Irma Ares, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases, and PPARs have been shown to regulate its progression. This review systematically summarizes literature on cardiac fibrosis from 2010 to 2020, clarifying the role of PPARs and discussing treatment strategies against cardiac fibrosis based on PPAR activity.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Ni Tien, Tien-Yuan Wu, Cheng-Li Lin, Fang-Yi Chu, Charles C. N. Wang, Chung Y. Hsu, Fuu-Jen Tsai, Yi-Jen Fang, Yun-Ping Lim
Summary: Recent studies have suggested a potential association between epilepsy and type 2 diabetes mellitus (T2DM), but the relationship between epilepsy, anti-epileptic drugs (AEDs), and the risk of T2DM development remains controversial. This nationwide, population-based, retrospective cohort study found that patients with epilepsy had a higher risk of developing T2DM, and certain AEDs, such as valproate, might have a protective effect against T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Fisheries
Victoria Gomez-Abellan, Ana B. Perez-Oliva, Isabel Cabas, Fatma Hermi, Marta Arizcun, Diana Garcia-Moreno, Maria P. Sepulcre, Victoriano Mulero
Summary: This study revealed that 15dPGJ(2) acts on fish granulocytes by activating PPARs and covalently binding to proteins. Additionally, 15dPGJ(2) decreased ROS production induced by bacterial DNA and the expression of certain cytokines.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Biochemistry & Molecular Biology
Chaitra Rai, C. D. Nandini, Poornima Priyadarshini
Summary: The study demonstrated the anti-adipogenic activity of bovine milk Glycosaminoglycans (bmGAGs) by modulating adipogenesis-related marker proteins, suggesting a potential therapeutic use of bmGAGs in the management of obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mahesha Gangadhariah, Triveni Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh
Summary: PPAR gamma agonists are effective in treating type 2 diabetes but have severe side effects. Lemon contains eriocitrin, which may have potential as a PPAR gamma agonist.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
V. Oralova, E. Matalova, M. Killinger, L. Knopfova, J. Smarda, M. Buchtova
CALCIFIED TISSUE INTERNATIONAL
(2017)
Article
Nutrition & Dietetics
Jirina Hofmanova, Josef Slavik, Petra Ovesna, Zuzana Tylichova, Jan Vondracek, Nicol Strakova, Alena Hyrslova Vaculova, Miroslav Ciganek, Alois Kozubik, Lucie Knopfova, Jan Smarda, Miroslav Machala
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Endocrinology & Metabolism
Katarina Chalasova, Lukas Pacal, Anna Pleskacova, Lucia Knopfova, Jitka Rehorova, Marie Tomandlova, Josef Tomandl, Katerina Kankova
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2018)
Article
Biochemistry & Molecular Biology
L. Knopfova, E. Biglieri, N. Volodko, M. Masarik, M. Hermanova, J. F. Glaus Garzon, M. Ducka, T. Kucirkova, K. Soucek, J. Smarda, P. Benes, L. Borsig
Article
Oncology
Jan Remsik, Lucia Bino, Zuzana Kahounova, Gvantsa Kharaishvili, Sarka Simeckova, Radek Fedr, Tereza Kucirkova, Sara Lenart, Ximena Maria Muresan, Eva Slabakova, Lucia Knopfova, Jan Bouchal, Milan Kral, Petr Benes, Karel Soucek
Article
Oncology
Marko Roblek, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, Mathias Heikenwalder, Bruno Luckow, Stefan W. Schneider, Lubor Borsig
MOLECULAR CANCER RESEARCH
(2019)
Article
Physiology
J. Prucha, J. Skopalik, V Socha, L. Hanakova, L. Knopfova, K. Hana
PHYSIOLOGICAL RESEARCH
(2019)
Article
Biochemical Research Methods
Jakub Faktor, Lucia Knopfova, Petr Lapcik, Lucia Janacova, Vendula Paralova, Pavla Bouchalova, Petr Mueller, Petr Benes, Pavel Bouchal
Article
Multidisciplinary Sciences
Nataliya Volodko, Taras Gutor, Orest Petronchak, Roman Huley, Monika Ducka, Jan Smarda, Lubor Borsig, Petr Benes, Lucia Knopfova
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Ladislava Vymetalova, Tereza Kucirkova, Lucia Knopfova, Veronika Pospisilova, Tomas Kasko, Hana Lejdarova, Eva Makaturova, Petr Kuglik, Veronika Oralova, Eva Matalova, Petr Benes, Zdenek Koristek, Serhiy Forostyak
NEUROCHEMICAL RESEARCH
(2020)
Article
Chemistry, Analytical
Antonin Bednarik, Jan Preisler, Dominika Bezdekova, Marketa Machalkova, Michal Hendrych, Jarmila Navratilova, Lucia Knopfova, Eugene Moskovets, Jens Soltwisch, Klaus Dreisewerd
ANALYTICAL CHEMISTRY
(2020)
Article
Oncology
Monika Ducka, Martina Kucerikova, Filip Trcka, Jakub Cervinka, Elisabetta Biglieri, Jan Smarda, Lubor Borsig, Petr Benes, Lucia Knopfova
Summary: c-Myb is involved in the activation of genes with protumorigenic function, and its interaction with IL1 alpha and NF-kappa B signaling axis in tumor cells plays a critical role in regulating metastasis and inflammatory genes in breast cancer. This pathway presents a potential target for therapeutic interventions to mimic the antimetastatic effect of c-Myb.
Article
Oncology
Kamila Rihova, Monika Ducka, Iva Staniczkova Zambo, Ladislava Vymetalova, Martin Sramek, Filip Trcka, Jan Verner, Stanislav Drapela, Radek Fedr, Tereza Suchankova, Barbora Pavlatovska, Eva Ondrouskova, Irena Kubelkova, Danica Zapletalova, Stepan Tucek, Peter Mudry, Dagmar Adamkova Krakorova, Lucia Knopfova, Jan Smarda, Karel Soucek, Lubor Borsig, Petr Benes
Summary: c-Myb is a negative prognostic factor in osteosarcoma, involved in regulating cell growth, chemosensitivity, migration, and metastatic activity in osteosarcoma cells.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Oncology
Merel van Gogh, Jesus F. Glaus Garzon, Dilara Sahin, Lucia Knopfova, Petr Benes, Onur Boyman, Igor Jurisica, Lubor Borsig
Summary: The authors demonstrate that c-Myb expression in tumor cells induces the expression of immune-related genes, leading to immunomodulation and inhibition of tumor growth.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Michal Tichy, Lucia Knopfova, Jiri Jarkovsky, Petr Vlcek, Jana Katolicka, Ivan Capov, Marketa Hermanova, Jan Smarda, Petr Benes
