Article
Multidisciplinary Sciences
Arshad Mahmood, Alia Erum, Ume Ruqia Tulain, Nadia Shamshad Malik, Aneeqa Saleem, Mohammed S. Alqahtani, Muhammad Zubair Malik, Mahwish Siddiqui, Asif Safdar, Abdul Malik, Vineet Kumar Rai
Summary: This research aimed to develop a stable nimesulide emulgel using arabinoxylan, a natural gelling agent extracted from Plantago ovata. The response surface methodology was used to optimize the emulgel formulation. The developed emulgel showed excellent stability, desired release profile, and effective analgesic effect, making it a promising drug delivery system.
Review
Pharmacology & Pharmacy
Mahipal Reddy Donthi, Siva Ram Munnangi, Kowthavarapu Venkata Krishna, Ranendra Narayan Saha, Gautam Singhvi, Sunil Kumar Dubey
Summary: Nano-emulgel is a novel drug delivery system that aims to enhance the therapeutic effectiveness of lipophilic drugs. It addresses the limitations of lipophilic formulations such as poor solubility, unpredictable absorption, and low oral bioavailability. By incorporating nano-emulsion into gel, the stability and drug delivery for immediate and controlled release are improved. The focus on nano-emulgel has increased due to its targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review discusses the formulation components, pharmacokinetics, and safety profiles of nano-emulgel for topical drug delivery.
Editorial Material
Biotechnology & Applied Microbiology
Parteek Prasher, Mousmee Sharma
Summary: Layered double hydroxide nanocarriers can enhance the pharmacokinetics and bioavailability of hydrophobic NSAIDs, such as mefenamic acid.
Article
Pharmacology & Pharmacy
Jeanri Myburgh, Wilna Liebenberg, Clarissa Willers, Admire Dube, Minja Gerber
Summary: This study evaluated the suitability of three nano-based transdermal drug delivery systems containing ibuprofen and assessed their drug release, skin permeation, and safety. The results showed that these nano-based drug delivery systems could effectively deliver ibuprofen transdermally, leading to potential improvements in pain management strategies.
Article
Pharmacology & Pharmacy
Luis Castillo-Henriquez, Pablo Sanabria-Espinoza, Brayan Murillo-Castillo, Gabriela Montes de Oca-Vasquez, Diego Batista-Menezes, Briner Calvo-Guzman, Nils Ramirez-Arguedas, Jose Vega-Baudrit
Summary: A suitable chitosan-based thermo-responsive scaffold was developed for controlled release of Dexketoprofen trometamol, with formulation prototype F3 showing the most controlled release at 32 degrees C for 24 h. SEM morphology examination and in vitro release studies confirmed the efficacy of the scaffold in overcoming adherence issues and complications in wound healing applications.
Review
Pharmacology & Pharmacy
S. Malavi, P. Kumbhar, A. Manjappa, S. Chopade, O. Patil, Udichi Kataria, J. Dwivedi, J. Disouza
Summary: Emulgel is a promising drug delivery strategy for topical delivery of hydrophobic drugs. It has a dual release control system and several favorable properties for dermatological use. However, it also has limitations, leading to the emergence of advanced concept nanoemulgel. Nanoemulgel formulations can be considered as impending and promising candidates for topical delivery of lipophilic drugs in the future.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Onyinye Uwaezuoke, Lisa C. Du Toit, Pradeep Kumar, Naseer Ally, Yahya E. Choonara
Summary: This study investigated the potential use of transferosomes for delivering cyclosporine A to the eye. Linoleic acid was found to improve the stability and size of the transferosomes. Tween(R)-based formulation was preferred due to its lower toxicity profile. The prepared transferosomes showed significant drug release and adequate corneal permeability, remaining stable for four months at low temperature.
Article
Engineering, Chemical
Nikhat Perween, Sultan Alshehri, T. S. Easwari, Vivek Verma, Md Faiyazuddin, Abdullah Alanazi, Faiyaz Shakeel
Summary: This study investigated the feasibility of preparing mefenamic acid (MA) oral nanosuspension using nanosuspension technology. By optimizing techniques and excipients, a stable nanosuspension with small particle size and excellent biocompatibility was successfully developed.
Article
Polymer Science
Aidawati Mohamed Shabery, Riyanto Teguh Widodo, Zamri Chik
Summary: This study aimed to develop semisolid niosomal encapsulated lidocaine and prilocaine using the patented palm oil base Hamin-C-(R) and evaluate their in vivo pain assessment. Niosome formulations were prepared using a thin-layer film hydration method and various chemical compositions. NIO-HAMIN F1-C emulgel showed improved viscosity and higher diffusion of lidocaine and prilocaine compared to other formulations. In vivo pain perception studies confirmed comparable local anesthetic effect between NIO-HAMIN F1-C emulgel and EMLA((R)) cream.
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Laura Tebcharani, Caren Wanzke, Theresa M. Lutz, Jennifer Rodon-Fores, Oliver Lieleg, Job Boekhoven
Summary: This study introduces a drug delivery system using a gellified emulsion for zero-order release of hydrophobic drugs, demonstrating tunable release rate and period by varying initial oil and drug concentrations. The system's quantitative understanding allows for predicting drug release kinetics, and it remains fully functional even after storing at -20 degrees C. Cell viability studies confirm the non-toxicity of the hydrolyzable oil and its hydrolysis product under the utilized conditions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Anna Gliszczynska, Elena Sanchez-Lopez
Summary: The S-(+) enantiomer of ibuprofen, dexibuprofen (DXI), is more potent than its R-(-) form with lower toxicity, greater clinical efficacy, and lesser variability in therapeutic effects. Recent research suggests that DXI not only has anti-inflammatory properties but also potential in reducing cancer development and preventing neurodegenerative diseases. Novel formulations of DXI are being designed to enhance therapeutic benefits and minimize adverse effects.
Review
Chemistry, Medicinal
Maria Talat, Muhammad Zaman, Rahima Khan, Muhammad Jamshaid, Muneeba Akhtar, Agha Zeeeshan Mirza
Summary: Emulgels are an emerging drug delivery system that combines the characteristics of emulsion and gel. They are easy to use, improve patient compliance, have a pleasing appearance and texture, long shelf life, and transparency.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Review
Pharmacology & Pharmacy
Piyush Verma, Khushwant S. Yadav
Summary: Tranexamic acid is a drug used for the treatment of hyperpigmentation, and topical administration is the most favorable route. However, low penetration and availability at target cells limit tranexamic acid's topical administration.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Muhammad Sohail, Mirza Muhammad Faran Ashraf Baig, Naveed Akhtar, Yue Chen, Bin Xie, Bingzhi Li
Summary: A lycopene-based topical emulgel was developed and demonstrated to have positive impacts on biophysical parameters of human skin, such as increased skin hydration and elasticity, and reduced erythema, melanin, and sebum contents. This was mainly attributed to the potent antioxidant potential of lycopene in the formulation. Additionally, sensory evaluation by volunteers indicated that the formulation would be commercially acceptable.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
