Review of therapeutic options and the management of patients with myelodysplastic syndromes

Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

(2012) Guillermo Garcia-Manero   AMERICAN JOURNAL OF HEMATOLOGY

Why Are Myelodysplastic Syndromes Unrecognized and Underdiagnosed?: A Primary Care Perspective

(2012) Awais M. Khan   AMERICAN JOURNAL OF MEDICINE

Clinical Presentation, Diagnosis, and Prognosis of Myelodysplastic Syndromes

(2012) James M. Foran et al.   AMERICAN JOURNAL OF MEDICINE

Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes

(2012) M. A. Sekeres et al.   BLOOD

Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with "normal" FISH: correlations with clinicobiologic parameters

(2012) G. M. Rigolin et al.   BLOOD

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

Optimizing hypomethylating agents in myelodysplastic syndromes

(2012) Raphael Itzykson et al.   CURRENT OPINION IN HEMATOLOGY

Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox

(2012) Shohei Kikuchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Outcome of patients with low-risk myelodysplasia after azacitidine treatment failure

(2012) T. Prebet et al.   HAEMATOLOGICA

Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes

(2012) N. Gattermann et al.   HAEMATOLOGICA

Improved survival in MDS patients receiving iron chelation therapy – A matched pair analysis of 188 patients from the Düsseldorf MDS registry

(2012) Judith Neukirchen et al.   LEUKEMIA RESEARCH

The clinical, quality of life, and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromes

(2012) Uwe Platzbecker et al.   LEUKEMIA RESEARCH

Aging of the Microenvironment Influences Clonality in Hematopoiesis

(2012) Virag Vas et al.   PLoS One

Management of High Ferritin in Long-Term Survivors After Hematopoietic Stem Cell Transplantation

(2012) Eolia Brissot et al.   SEMINARS IN HEMATOLOGY

Incidence of the myelodysplastic syndromes using a novel claims-based algorithm: high number of uncaptured cases by cancer registries

(2011) C. R. Cogle et al.   BLOOD

A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q

(2011) P. Fenaux et al.   BLOOD

An integrated analysis of germline and somatic, genetic and epigenetic alterations at 9p21.3 in glioblastoma

(2011) Junjie Feng et al.   CANCER

Significance of Thrombocytopenia in Myelodysplastic Syndromes: Associations and Prognostic Implications

(2011) Ali Al Ameri et al.   Clinical Lymphoma Myeloma & Leukemia

Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

(2011) A. Rio-Machin et al.   HAEMATOLOGICA

Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

(2011) L. Malcovati et al.   HAEMATOLOGICA

Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   JOURNAL OF CLINICAL ONCOLOGY

How to manage lower-risk myelodysplastic syndromes

(2011) M A Sekeres   LEUKEMIA

Update on cytogenetic and molecular changes in myelodysplastic syndromes

(2011) Brigitte Schlegelberger et al.   LEUKEMIA & LYMPHOMA

352 Iron overload in low-risk myelodysplastic syndromes (MDS): A multicentric study

(2011) S. Improta et al.   LEUKEMIA RESEARCH

Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox

(2011) Florian Nolte et al.   LEUKEMIA RESEARCH

The long term risk of myelodysplastic syndromes among anemia patients: A population-based study

(2011) D. Meytes et al.   LEUKEMIA RESEARCH

Biology and treatment of the 5q- syndrome

(2011) Eric Padron et al.   Expert Review of Hematology

Immunomodulating Drugs in Myelodysplastic Syndromes

(2011) L. Ades et al.   Hematology-American Society of Hematology Education Program

Transfusion intensity, not the cumulative red blood cell transfusion burden, determines the prognosis of patients with myelodysplastic syndrome on chronic transfusion support

(2010) Arturo Pereira et al.   AMERICAN JOURNAL OF HEMATOLOGY

Eltrombopag: A Novel Oral Thrombopoietin Receptor Agonist

(2010) S. L. Corman et al.   ANNALS OF PHARMACOTHERAPY

Controversies surrounding iron chelation therapy for MDS

(2010) Heather A. Leitch   BLOOD REVIEWS

Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy

(2010) Elias Jabbour et al.   CANCER

Myelodysplastic syndromes: A practical approach to diagnosis and treatment

(2010) A. BARZI et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Epigenetic Changes in the Myelodysplastic Syndrome

(2010) Jean-Pierre Issa   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

(2010) Alexander Kohlmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Alemtuzumab Treatment of Intermediate-1 Myelodysplasia Patients Is Associated With Sustained Improvement in Blood Counts and Cytogenetic Remissions

(2010) Elaine M. Sloand et al.   JOURNAL OF CLINICAL ONCOLOGY

Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM

(2010) Christian Rose et al.   LEUKEMIA RESEARCH

Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

(2010) Norbert Gattermann et al.   LEUKEMIA RESEARCH

Early Deferasirox Treatment in a Patient with Myelodysplastic Syndrome Results in a Long-Term Reduction in Transfusion Requirements

(2009) Silvana Capalbo et al.   ACTA HAEMATOLOGICA

Myelodysplastic Syndromes

(2009) Attilio Orazi et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?

(2009) V. Pullarkat   BLOOD

Elevated pretransplant ferritin is associated with a lower incidence of chronic graft-versus-host disease and inferior survival after myeloablative allogeneic haematopoietic stem cell transplantation

(2009) Anuj Mahindra et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma

(2009) Christine Chen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Platelet counts and haemorrhagic diathesis in patients with myelodysplastic syndromes

(2009) Judith Neukirchen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes

(2009) A. A. van de Loosdrecht et al.   HAEMATOLOGICA

Deferasirox: An Update

(2009) John B. Porter   HEMOGLOBIN

Safety and Efficacy of Romiplostim in Patients With Lower-Risk Myelodysplastic Syndrome and Thrombocytopenia

(2009) Hagop Kantarjian et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Impact of transfusion dependency on survival in patients with early myelodysplastic syndrome without excess of blasts

(2009) Jaroslav Cermak et al.   LEUKEMIA RESEARCH

P104 Change in liver iron concentration (LIC), serum ferritin (SF) and labile plasma iron (LPI) over 1 year of deferasirox (Exjade®) therapy in a cohort of patients with MDS

(2009) P.L. Greenberg et al.   LEUKEMIA RESEARCH

P103 Iron chelation treatment in patients with myelodysplastic syndromes (MDS): the experience of the Hellenic MDS Study Group

(2009) A. Kouraklis et al.   LEUKEMIA RESEARCH

Impact of pre-transplant serum ferritin on outcomes of patients with myelodysplastic syndromes or secondary acute myeloid leukaemia receiving reduced intensity conditioning allogeneic haematopoietic stem cell transplantation

(2009) Z.Y. Lim et al.   LEUKEMIA RESEARCH

Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes

(2009) Akira Matsuda et al.   LEUKEMIA RESEARCH

Acquired mutations in TET2 are common in myelodysplastic syndromes

(2009) Saskia M C Langemeijer et al.   NATURE GENETICS

Myelodysplastic Syndromes

(2009) Ayalew Tefferi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of transfusional iron overload in patients with myelodysplastic syndrome or severe anemia: data from multicenter clinical practices

(2009) Anastasios Raptis et al.   TRANSFUSION

Supportive care and chelation therapy in MDS: are we saving lives or just lowering iron?

(2009) H. A. Leitch et al.   Hematology-American Society of Hematology Education Program

Deferasirox Treatment Improved the Hemoglobin Level and Decreased Transfusion Requirements in Four Patients with the Myelodysplastic Syndrome and Primary Myelofibrosis

(2008) E. Messa et al.   ACTA HAEMATOLOGICA

Consensus statement on iron overload in myelodysplastic syndromes

(2008) John M. Bennett et al.   AMERICAN JOURNAL OF HEMATOLOGY

Epidemiology, classification and prognosis of adults and children with myelodysplastic syndromes

(2008) Ulrich Germing et al.   ANNALS OF HEMATOLOGY

Elevated Ferritin Is Associated with Relapse after Autologous Hematopoietic Stem Cell Transplantation for Lymphoma

(2008) Anuj Mahindra et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Red Blood Cell Transfusion Dependence and Outcome after Allogeneic Peripheral Blood Stem Cell Transplantation in Patients with de Novo Myelodysplastic Syndrome (MDS)

(2008) Uwe Platzbecker et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection

(2008) C. C. Porter et al.   BLOOD

Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA Group

(2008) M. A. Sanz et al.   BLOOD

Hematopoiesis is not clonal in healthy elderly women

(2008) S. I. Swierczek et al.   BLOOD

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs

(2008) D. E. Rollison et al.   BLOOD

The role of iron in patients after bone marrow transplantation

(2008) Theo de Witte   BLOOD REVIEWS

Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation

(2008) V Pullarkat et al.   BONE MARROW TRANSPLANTATION

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Myocardial iron overload assessment by T2* magnetic resonance imaging in adult transfusion dependent patients with acquired anemias

(2008) A. A. Di Tucci et al.   HAEMATOLOGICA

Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes

(2008) Takahiro Suzuki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload

(2008) Norbert Gattermann   INTERNATIONAL JOURNAL OF HEMATOLOGY

Factors Affecting Response and Survival in Patients With Myelodysplasia Treated With Immunosuppressive Therapy

(2008) Elaine M. Sloand et al.   JOURNAL OF CLINICAL ONCOLOGY

Iron overload in myelodysplastic syndromes: A Canadian consensus guideline

(2008) Richard A. Wells et al.   LEUKEMIA RESEARCH

Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes

(2008) M. Cazzola et al.   Hematology-American Society of Hematology Education Program

Flow cytometry in myelodysplastic syndromes: Report from a working conference

(2007) Michael R. Loken et al.   LEUKEMIA RESEARCH