Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Yakup Kilic, Shahed Kamal, Farah Jaffar, Danujan Sriranganathan, Mohammed Nabil Quraishi, Jonathan P. Segal
Summary: Inflammatory bowel disease (IBD) is a multisystem disease that affects various body systems. The extraintestinal manifestations of IBD are frequent and impact the morbidity and mortality of patients with UC and CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castano-Rodriguez
Summary: ATG16L1 rs2241880 is significantly associated with susceptibility to Crohn's disease (CD) and influences clinical outcomes, especially in Caucasian populations.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Laura Arp, Sabine Jansson, Vibeke Wewer, Johan Burisch
Summary: The prevalence of psychiatric comorbidities is high in patients with inflammatory bowel diseases (IBD) and higher than in the general population. Addressing mental health problems in these patients can improve treatment adherence, disease course, and reduce morbidity and mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lili He, Yinghua Sun, Xihong Hu, Qiong Yao
Summary: The meta-analysis indicates that MRE performs well in detecting IBD in pediatric patients. Only two studies used US, suggesting that additional research is needed to confirm the diagnostic performance of US for IBD in children.
EUROPEAN RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Xiaoding Shen, Qianyi Wan, Rui Zhao, Yutao Wu, Yong Wang, Yaping Cui, Xiangnan Su, Xiaoting Wu
Summary: The umbrella review of 25 meta-analyses found that patients with inflammatory bowel diseases had a higher risk of adverse health outcomes in various aspects, but the quality of evidence was generally low. More research is needed to draw firmer conclusions.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Gastroenterology & Hepatology
Hailan Zhao, Haoming Xu, Shuzhen Chen, Jie He, Youlian Zhou, Yuqiang Nie
Summary: A systematic review and meta-analysis found a negative association between abundance of F. prausnitzii and IBD activity, but a cut-off level of F. prausnitzi for diagnosing and treating IBD has not been determined.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Irene Marafini, Edoardo Troncone, Irene Rocchetti, Giovanni Monteleone
Summary: The study found that patients with inflammatory bowel disease treated with vedolizumab had a higher risk of respiratory infections, especially for those with ulcerative colitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Min Yuan, Lijun Xu, Xiaoping Yin
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2016)
Letter
Medicine, General & Internal
Min Yuan, Xu-Fang Xie, Wen-Feng Cao, Ying-Qiong Xiong, Ling-Feng Wu, Huang-Yan Zhou, Xiao-Mu Wu
MEDICAL PRINCIPLES AND PRACTICE
(2018)
Review
Medicine, General & Internal
Min Yuan, Wen-Feng Cao, Xu-Fang Xie, Huang-Yan Zhou, Xiao-Mu Wu
Review
Medicine, General & Internal
Huang-yan Zhou, Min Yuan
Article
Clinical Neurology
Qi Zhou, Min Yuan, Weiwen Qiu, Wenfeng Cao, Renshi Xu
Summary: The study assessed the quality of preclinical evidence for MSCs therapy of ALS, determined the effect size of MSCs treatment, and identified clinical parameters associated with differences in MSCs effects. The results showed that MSCs transplantation was beneficial for neurobehavioral improvement in ALS animal models, with animal gender and immunosuppressive drug CSA having a close correlation with disease progression deceleration effect size.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Min Yuan, Huang-Yan Zhou, Fan Hu, Shi-Ying Liu, Wei Rao, Ling-Feng Wu, Hong-Bing Nie, Wen-Feng Cao
Summary: This meta-analysis found that patients with kidney stones have a slightly increased risk of developing stroke, especially ischemic stroke. Larger-scale clinical trials are needed to further identify the relative impact of kidney stones on stroke outcomes.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Min Yuan, Zhi-Long Xiao, Huang-Yan Zhou, Wei Rao, Gang Huang, Hong-Bing Nie, Wen-Feng Cao, Ren-Shi Xu
Summary: This meta-analysis of 7 studies involving 13,305,007 participants found that individuals with BD have a significantly increased risk of both stroke incidence and mortality compared to those without BD. Further research should be conducted to determine if BD is a modifiable risk factor for stroke.
NEUROLOGICAL SCIENCES
(2022)
Review
Cell Biology
Yu Zhu, Min Yuan, Yue Liu, Fang Yang, Wen-Zhi Chen, Zhen-Zhen Xu, Zheng-Bing Xiang, Ren-Shi Xu
Summary: There is evidence suggesting a correlation between inflammatory bowel disease and Parkinson's disease, especially in older patients with IBD. Early anti-inflammatory treatment may reduce the risk of developing PD.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Min Yuan, Xinhua Zhou, Xiaoqing Lu, Zhilong Xiao, Huangyan Zhou, Xiaohua Wang
Summary: This study found that statin use during hospitalization may be associated with a reduced risk-adjusted mortality in patients with intracerebral hemorrhage (ICH). Further randomized controlled trials are needed to clarify this association.
Article
Nutrition & Dietetics
Shaoyan Cai, Qinjia Wang, Chao Chen, Chunming Guo, Liangjie Zheng, Min Yuan
Summary: This study found a significant association between the blood urea nitrogen to serum albumin ratio (BAR) and in-hospital mortality in patients with sepsis. A higher BAR was associated with worse prognosis in the ICU.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Hui Wang, Binbin Hu, Juan Huang, Lin Chen, Min Yuan, Xingfu Tian, Ting Shi, Jiahao Zhao, Wei Huang
Summary: The study aimed to analyze the clinical features and gait characteristics of PD patients with fatigue and develop a model to identify fatigue in the early stages of PD. The results showed that PD patients with fatigue had more severe impairment of motor symptoms and fatigue became more pronounced as the disease progressed. Combining clinical characteristics and gait cycle parameters can identify PD patients at high risk of fatigue.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pathology
Min Yuan, Chengyu Li, Xiang Xiao, Dengfeng Wan, Bin Xi, Xingxing Jiang, Jianzhong Zhang
Summary: Lentinan effectively inhibits proliferation and promotes apoptosis of human astrocytoma U251 cells. When the concentration exceeds 100 μg/ml, cell activity gradually decreases, with the lowest activity at a concentration of 600 μg/ml. Low concentrations of Lentinan (25, 50, and 100 μg/ml) had no significant effect on apoptosis of human astrocytoma U251 cells. However, Lentinan above 200 μg/ml significantly promoted apoptosis and showed a concentration gradient effect, with the highest apoptosis rate at 600 μg/ml.
POLISH JOURNAL OF PATHOLOGY
(2023)
Letter
Medicine, General & Internal
Min Yuan, Huang-Yan Zhou, Ling-Feng Wu, Wen-Feng Cao, Ren-Shi Xu
CHINESE MEDICAL JOURNAL
(2021)
Review
Cell Biology
Ren-Shi Xu, Min Yuan
Summary: The concept, definition, and diagnosis of amyotrophic lateral sclerosis (ALS) pose some challenges, with a lack of unity and standardization in clinical practice. Future research should focus on identifying reliable biomarkers, particularly neuroimaging biomarkers, for the early and accurate diagnosis of ALS to benefit patients.
NEURAL REGENERATION RESEARCH
(2021)
Letter
Peripheral Vascular Disease
Min Yuan, Huang-Yan Zhou
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2020)
