The Non-coding Road Towards Cardiac Regeneration

Complete cardiac regeneration in a mouse model of myocardial infarction

(2016) Bernhard Johannes Haubner et al.   Aging-US

Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

(2013) Carla A. Klattenhoff et al.   CELL

mir-17–92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts

(2013) Jinghai Chen et al.   CIRCULATION RESEARCH

microRNAs in cardiac development and regeneration

(2013) Enzo R. Porrello   CLINICAL SCIENCE

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

Parthenogenetic stem cells for tissue-engineered heart repair

(2013) Michael Didié et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

(2013) Ahmed I. Mahmoud et al.   NATURE

Embryonic Cardiomyocyte, but Not Autologous Stem Cell Transplantation, Restricts Infarct Expansion, Enhances Ventricular Function, and Improves Long-Term Survival

(2013) Leonie E. Paulis et al.   PLoS One

Reprogramming of human fibroblasts toward a cardiac fate

(2013) Y.-J. Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is junk DNA bunk? A critique of ENCODE

(2013) W. F. Doolittle   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte proliferation contributes to heart growth in young humans

(2013) Mariya Mollova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Engineering of Vascularized Tissue Surrogates

(2013) Katsuhisa Sakaguchi et al.   Scientific Reports

Differential Expression of MicroRNAs During Allograft Rejection

(2012) L. Wei et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

(2012) Jenny X. Chen et al.   CIRCULATION RESEARCH

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

Long Noncoding RNAs in Cardiac Development and Pathophysiology

(2012) Nicole Schonrock et al.   CIRCULATION RESEARCH

MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia

(2012) Gaia Spinetti et al.   CIRCULATION RESEARCH

Effect of Cardiac Stem Cells on Left-Ventricular Remodeling in a Canine Model of Chronic Myocardial Infarction

(2012) Frederick G.P. Welt et al.   Circulation-Heart Failure

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC

(2012) et al.   EUROPEAN HEART JOURNAL

What to do with functional mitral regurgitation: what do we really know and how can we find out?

(2012) J. H. Rogers et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

A Novel Cardiomyocyte-enriched MicroRNA, miR-378, Targets Insulin-like Growth Factor 1 Receptor

(2012) Ivana Knezevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells

(2012) Stephanie Protze et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac stem cells in patients with ischaemic cardiomyopathy

(2012) Christof Stamm et al.   LANCET

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

(2012) Raj R Makkar et al.   LANCET

Kill the messenger where it lives

(2012) Peter K. Todd et al.   NATURE

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

(2012) Yuji Shiba et al.   NATURE

Targeting nuclear RNA for in vivo correction of myotonic dystrophy

(2012) Thurman M. Wheeler et al.   NATURE

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Lessons from human teratomas to guide development of safe stem cell therapies

(2012) Justine J Cunningham et al.   NATURE BIOTECHNOLOGY

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

Methylation of p15INK4b and Expression of ANRIL on Chromosome 9p21 Are Associated with Coronary Artery Disease

(2012) Jianhui Zhuang et al.   PLoS One

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

(2012) I. A. Babar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning Back the Cardiac Regenerative Clock: Lessons From the Neonate

(2012) Ahmed I. Mahmoud et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Optimizing Cardiac Repair and Regeneration Through Activation of the Endogenous Cardiac Stem Cell Compartment

(2012) Georgina M. Ellison et al.   Journal of Cardiovascular Translational Research

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B

(2011) Ada Congrains et al.   ATHEROSCLEROSIS

MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1

(2011) Huaqing Zhu et al.   CARDIOVASCULAR RESEARCH

Non-cardiomyocyte microRNAs in heart failure

(2011) A. J. Tijsen et al.   CARDIOVASCULAR RESEARCH

Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution

(2011) Igor Ulitsky et al.   CELL

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair

(2011) Francesco S. Loffredo et al.   Cell Stem Cell

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

(2011) Frederick Anokye-Danso et al.   Cell Stem Cell

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

(2011) James J.H. Chong et al.   Cell Stem Cell

Novel MicroRNA Prosurvival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation

(2011) S. Hu et al.   CIRCULATION

MicroRNA-24 Regulates Vascularity After Myocardial Infarction

(2011) Jan Fiedler et al.   CIRCULATION

Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

(2011) Rusty L. Montgomery et al.   CIRCULATION

Role of Cardiac Stem Cells in Cardiac Pathophysiology: A Paradigm Shift in Human Myocardial Biology

(2011) Annarosa Leri et al.   CIRCULATION RESEARCH

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

(2011) Enzo R. Porrello et al.   CIRCULATION RESEARCH

Inhibition of miR-15 Protects Against Cardiac Ischemic Injury

(2011) Thomas G. Hullinger et al.   CIRCULATION RESEARCH

The central role of RNA in human development and cognition

(2011) John S. Mattick   FEBS LETTERS

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

(2011) Li Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts

(2011) Padmini Sirish et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart

(2011) Georgina M. Ellison et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial

(2011) Roberto Bolli et al.   LANCET

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells

(2011) Nicole C Dubois et al.   NATURE BIOTECHNOLOGY

The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

(2011) Feng Ma et al.   NATURE IMMUNOLOGY

Proteomic and phosphoproteomic comparison of human ES and iPS cells

(2011) Douglas H Phanstiel et al.   NATURE METHODS

NKX2-5 eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes

(2011) David A Elliott et al.   NATURE METHODS

Experimental strategies for microRNA target identification

(2011) D. W. Thomson et al.   NUCLEIC ACIDS RESEARCH

Sca-1+ Cardiac Stem Cells Mediate Acute Cardioprotection via Paracrine Factor SDF-1 following Myocardial Ischemia/Reperfusion

(2011) Chunyan Huang et al.   PLoS One

Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

(2011) Ji-Dong Fu et al.   PLoS One

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23 27 24 clusters

(2011) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Primitive Cardiac Cells from Human Embryonic Stem Cells

(2011) James Hudson et al.   STEM CELLS AND DEVELOPMENT

Development of Myocardial Constructs Using Modulus-Matched Acrylated Polypropylene Glycol Triol Substrate and Different Nonmyocyte Cell Populations

(2011) James E. Hudson et al.   TISSUE ENGINEERING PART A

MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells

(2010) Joost P.G. Sluijter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The long noncoding RNA RNCR2 directs mouse retinal cell specification.

(2010) Nicole A Rapicavoli et al.   BMC DEVELOPMENTAL BIOLOGY

Cardiomyocyte cell cycle control and growth estimation in vivo—an analysis based on cardiomyocyte nuclei

(2010) Stuart Walsh et al.   CARDIOVASCULAR RESEARCH

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals

(2010) Qiangzhe Zhang et al.   CELL RESEARCH

Building a New Heart From Old Parts

(2010) Enzo R. Porrello et al.   CIRCULATION RESEARCH

Myocyte Turnover in the Aging Human Heart

(2010) Jan Kajstura et al.   CIRCULATION RESEARCH

Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation

(2010) Konstantinos E. Hatzistergos et al.   CIRCULATION RESEARCH

Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

(2010) Isotta Chimenti et al.   CIRCULATION RESEARCH

Bmp Signaling Regulates Myocardial Differentiation from Cardiac Progenitors Through a MicroRNA-Mediated Mechanism

(2010) Jun Wang et al.   DEVELOPMENTAL CELL

Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

(2010) et al.   EUROPEAN HEART JOURNAL

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

(2010) Martin B. Leon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction

(2009) Eric D. Adler et al.   FASEB JOURNAL

Effect of Genome Size on AAV Vector Packaging

(2009) Zhijian Wu et al.   MOLECULAR THERAPY

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology

(2009) Anke M Smits et al.   Nature Protocols

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

(2009) K. R. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Improvement of mouse cardiac function by hESC-derived cardiomyocytes correlates with vascularity but not graft size

(2009) Linda W. van Laake et al.   Stem Cell Research

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

(2008) Kathryn N. Ivey et al.   Cell Stem Cell

Human Embryonic Stem Cell–Derived Cardiomyocytes and Cardiac Repair in Rodents

(2008) Linda W. van Laake et al.   CIRCULATION RESEARCH

Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

(2008) Massimiliano Gnecchi et al.   CIRCULATION RESEARCH

A Caudal Proliferating Growth Center Contributes to Both Poles of the Forming Heart Tube

(2008) Gert van den Berg et al.   CIRCULATION RESEARCH

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

(2008) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Features of cardiomyocyte proliferation and its potential for cardiac regeneration

(2008) Machteld J. van Amerongen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

(2008) Leo Timmers et al.   Stem Cell Research