Article
Biochemistry & Molecular Biology
Fanlu Wang, Lena Marie Saure, Fabian Schuett, Felix Lorich, Florian Rasch, Ali Shaygan Nia, Xinliang Feng, Andreas Seekamp, Tim Klueter, Hendrik Naujokat, Rainer Adelung, Sabine Fuchs
Summary: Graphene oxide shows promising potential in bone tissue engineering, but its molecular biological effects in clinically applied materials are still limited. This study compares the effects of graphene oxide framework structures (F-GO) and reduced graphene oxide-based framework structures (F-rGO) on bone vascularization processes. Non-reduced graphene oxide in the form of F-GO is favored for bone regeneration applications, and graphene oxide coating on a clinically used bone graft improves cell adhesion and vascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mona Sheta, Ghmkin Hassan, Said M. Afify, Sadia Monzur, Kazuki Kumon, Hagar A. Abu Quora, Mahmoud Farahat, Maram H. Zahra, Xiaoying Fu, Akimasa Seno, Masaharu Seno
Summary: The study found that under the influence of exogenous factors, FGF2 can successfully induce the conversion of normal stem cells into cancer stem cells, and this process is associated with FGF receptors, integrins, PI3K/AKT pathways, etc.
Article
Multidisciplinary Sciences
Chase A. Pagani, Alec C. Bancroft, Robert J. Tower, Nicholas Livingston, Yuxiao Sun, Jonathan Y. Hong, Robert N. Kent III, Amy L. Strong, Johanna H. Nunez, Jessica Marie R. Medrano, Nicole Patel, Benjamin A. Nanes, Kevin M. Dean, Zhao Li, Chunxi Ge, Brendon M. Baker, Aaron W. James, Stephen J. Weiss, Renny T. Franceschi, Benjamin Levi
Summary: Extracellular matrix (ECM) interactions and the cell surface receptor DDR2 play a critical role in regulating cell fate and the development of traumatic heterotopic ossification (HO).
Review
Engineering, Biomedical
Li Wang, Xinbo Wei, Yuqing Wang
Summary: Implantable tissue-engineered vascular grafts (TEVGs) elicit host reactions tied to the immune system, including blood-material interaction, protein absorption, inflammation, and foreign body reaction. The immune response, although not completely harmful, has both therapeutic and impaired effects on angiogenesis and tissue regeneration. This review focuses on immune cell regulation, particularly on macrophages, in the vasculature.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Review
Cell Biology
Henglei Shi, Zhenchen Zhao, Weidong Jiang, Peiqi Zhu, Nuo Zhou, Xuanping Huang
Summary: In addition to its transport functions, the skeletal system plays an important role in regulating blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells, have the ability to promote bone regeneration and vascularization through cooperation with other cells. EPCs have significant therapeutic potential for treating bone diseases by secreting growth factors and promoting bone regeneration. This review summarizes the definition, properties, and mechanisms of EPCs, as well as their role and potential clinical applications in the treatment of various bone diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vivian Wu, Engelbert A. J. M. Schulten, Marco N. Helder, Christiaan M. ten Bruggenkate, Nathalie Bravenboer, Jenneke Klein-Nulend
Summary: In this retrospective cohort study, it was found that maxillary tuberosity bone grafts showed better bone vitality and vascularization compared to mandibular retromolar bone grafts in patients undergoing maxillary sinus floor elevation for dental implant placement.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yan Hu, Xiaoqun Li, Xin Zhi, Wei Cong, Biaotong Huang, Huiwen Chen, Yajun Wang, Yinghua Li, Lipeng Wang, Chao Fang, Jiawei Guo, Ying Liu, Jin Cui, Liehu Cao, Weizong Weng, Qirong Zhou, Sicheng Wang, Xiao Chen, Jiacan Su
Summary: RANKL is essential for osteoclast formation and bone remodeling, with bone marrow adipose lineage cells being identified as a crucial cellular source for RANKL production. Conditional deletion of RANKL from these cells leads to an increase in cancellous bone mass in mice by reducing trabecular osteoclast formation and bone resorption, providing potential targets for preventing pathological bone loss.
Article
Dentistry, Oral Surgery & Medicine
Florian Boehrnsen, Petra Melsheimer, Mareike Natorp, Hans Rolf, Boris Schminke, Philipp Kauffmann, Susanne Wolfer, Henning Schliephake
Summary: The cotransplantation of pre-cultivated BMSC and HUVEC resulted in improved mineralization and vascularization of osteo-conductive scaffolds in vivo. However, no significant differences were observed between the implantation of BMSC-only, HUVEC-only, or BMSC thorn HUVEC cocultures, indicating the need for further investigation into the advantages of cotransplantation in tissue engineering for bone regeneration.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Multidisciplinary Sciences
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Summary: Osteoarthritis is characterized by irreversible degeneration of articular cartilage. Gremlin 1 marks a bipotent cell population on the articular surface, which plays a crucial role in chondrogenic and osteogenic progenitor cells. These cells are affected by injury and aging, leading to the development of osteoarthritis.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xu Li, Bingyang Dai, Jiaxin Guo, Yuwei Zhu, Jiankun Xu, Shunxiang Xu, Zhi Yao, Liang Chang, Ye Li, Xuan He, Dick Ho Kiu Chow, Shian Zhang, Hao Yao, Wenxue Tong, To Ngai, Ling Qin
Summary: A magnesium-based artificial bandage was fabricated to activate periosteum-associated biomineralization and promote bone healing. The bandage released magnesium ions to activate endogenous periosteal macrophages into M2 phenotype, and also stimulated blood vessel formation and neurite outgrowth. As a result, the surrounding newly formed bone tissue covered the defected area.
Article
Cell Biology
Domenico Aprile, Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Gianfranco Peluso, Umberto Galderisi
Summary: In this study, we investigated the role of SSEA-3 in MUSE cell behavior and its potential relationship with FGF2 activity. We found that the cooperation between SSEA-3 and FGF2 affects the self-renewal and clonogenic capacity of MUSE cells, and blocking SSEA-3 significantly reduces their multilineage potential.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Maria Jassinskaja, Kristyna Pimkova, Nejc Arh, Emil Johansson, Mina Davoudi, Carlos-Filipe Pereira, Ewa Sitnicka, Jenny Hansson
Summary: This study used mass spectrometry and functional assays to investigate the proteomic mechanisms regulating hematopoiesis, revealing distinct features and differentiation capacities between fetal and adult lympho-myeloid multipotent progenitors and granulocyte-monocyte progenitors. The results suggest a specific requirement of myosin activity for myelopoiesis in adult multipotent progenitors and an ontogenic shift in monocytic differentiation capacity of granulocyte-monocyte progenitors driven by differential expression of Irf8.
Article
Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Lin Zhong, Rui Liu, Weilu Gao, Hui Zhang, Zongsheng Yin
Summary: The study demonstrated that Nrg1 could effectively convert reactive astrocytes to oligodendrocytes, inhibit astrogliosis, promote remyelination, protect axons, and improve SCI symptoms, suggesting a promising therapeutic strategy for spinal cord repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Noreen Mumtaz, Amel Dudakovic, Asha Nair, Marijke Koedam, Johannes P. T. M. van Leeuwen, Marion P. G. Koopmans, Barry Rockx, Andre J. J. van Wijnen, Bram C. J. van der Eerden
Summary: Arboviruses like Zika virus affect bone development by targeting osteoblasts and altering bone remodeling. In this study, the researchers investigated the effects of Zika virus infection on mesenchymal stromal cells (MSCs) at different stages of osteogenesis. They found that late-stage infected MSCs showed elevated osteogenic markers, calcium content, and altered gene expression compared to early-stage infected MSCs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Immunology
Jianrui Zheng, Zhi Yao, Lixiang Xue, Deli Wang, Zhen Tan
Summary: Osteonecrosis is caused by the death of bone marrow cells, leading to abnormal immune function and chronic inflammation that interferes with bone regeneration and repair. Osteoimmunology explores the interactions between immune cells and bone cells, and understanding the chronic inflammatory environment regulated by abnormal osteoimmune function can help develop new treatments for osteonecrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Hongguo Li, Jiabing Fan, Liguo Sun, Xincheng Liu, Pengzhen Cheng, Hongbin Fan
Article
Materials Science, Biomaterials
Jiabing Fan, Liguo Sun, Xiaonan Chen, Ling Qu, Hongguo Li, Xincheng Liu, Yushen Zhang, Pengzhen Cheng, Hongbin Fan
JOURNAL OF MATERIALS CHEMISTRY B
(2017)
Article
Engineering, Biomedical
Liangliang Huang, Lei Zhu, Xiaowei Shi, Bing Xia, Zhongyang Liu, Shu Zhu, Yafeng Yang, Teng Ma, Pengzhen Cheng, Kai Luo, Jinghui Huang, Zhuojing Luo
ACTA BIOMATERIALIA
(2018)
Article
Cell & Tissue Engineering
Huijie Jiang, Pengzhen Cheng, Donglin Li, Junqin Li, Jimeng Wang, Yi Gao, Shuaishuai Zhang, Tianqing Cao, Chunmei Wang, Liu Yang, Guoxian Pei
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Cell & Tissue Engineering
Pengzhen Cheng, Donglin Li, Yi Gao, Tianqing Cao, Huijie Jiang, Jimeng Wang, Junqin Li, Shuaishuai Zhang, Yue Song, Bin Liu, Chunmei Wang, Liu Yang, Guoxian Pei
STEM CELL RESEARCH & THERAPY
(2018)
Article
Cell & Tissue Engineering
Shuaishuai Zhang, Junqin Li, Huijie Jiang, Yi Gao, Pengzhen Cheng, Tianqing Cao, Donglin Li, Jimeng Wang, Yue Song, Bin Liu, Hao Wu, Chunmei Wang, Liu Yang, Guoxian Pei
STEM CELLS INTERNATIONAL
(2018)