Modeling Reveals That Dynamic Regulation of c-FLIP Levels Determines Cell-to-Cell Distribution of CD95-mediated Apoptosis

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

(2009) A Kaunisto et al.   CELL DEATH AND DIFFERENTIATION

Activation-induced Degradation of FLIPLIs Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages

(2009) Bo Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

Construction and analysis of a modular model of caspase activation in apoptosis

(2008) Heather A Harrington et al.   Theoretical Biology and Medical Modelling

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

(2008) John G Albeck et al.   PLOS BIOLOGY