Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells

Impact of Metronomic UFT/Cyclophosphamide Chemotherapy and Antiangiogenic Drug Assessed in a New Preclinical Model of Locally Advanced Orthotopic Hepatocellular Carcinoma

(2015) Terence C. Tang et al.   NEOPLASIA

Compound K Induces Apoptosis of Bladder Cancer T24 Cells Via Reactive Oxygen Species-Mediated p38 MAPK Pathway

(2013) Han Wang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

HY-1 induces G2 / M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways

(2013) Yu Zhao et al.   CANCER SCIENCE

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells

(2013) Wen-xia Zhao et al.   CELL BIOLOGY AND TOXICOLOGY

The p27–Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells

(2013) Michael K Kullmann et al.   CELL CYCLE

Salvianolic Acid B Induces Apoptosis in Human Glioma U87 Cells Through p38-Mediated ROS Generation

(2013) Zi-shu Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

(2013) Zheng Wei et al.   CELLULAR SIGNALLING

Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma

(2013) Qing-Feng Zou et al.   Journal of Translational Medicine

Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia

(2013) Olga N. Uchakina et al.   LEUKEMIA RESEARCH

Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-κB, and SIRT1 Signaling Pathway

(2013) Hwa-Jeong Lee et al.   PLANTA MEDICA

MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3

(2013) Noelia Sanchez et al.   PLoS One

Static Mechanical Stress Induces Apoptosis in Rat Endplate Chondrocytes through MAPK and Mitochondria-Dependent Caspase Activation Signaling Pathways

(2013) Dechao Kong et al.   PLoS One

Traditional West African pharmacopeia, plants and derived compounds for cancer therapy

(2012) Wamtinga Richard Sawadogo et al.   BIOCHEMICAL PHARMACOLOGY

Musca Domestica Larva Lectin Induces Apoptosis in BEL-7402 Cells Through a Ca2+/JNK-mediated Mitochondrial Pathway

(2012) Chun-Ling Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

CDK inhibitor p57Kip2is negatively regulated by COP9 signalosome subunit 6

(2012) Bo Chen et al.   CELL CYCLE

Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx

(2012) Wei-Guang Wang et al.   JOURNAL OF NATURAL PRODUCTS

All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2

(2012) Baofeng Su et al.   JOURNAL OF NEPHROLOGY

Ternifolide A, a New Diterpenoid Possessing a Rare Macrolide Motif from Isodon ternifolius

(2012) Juan Zou et al.   ORGANIC LETTERS

Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro

(2012) Chun-Tang Chiou et al.   PHYTOCHEMISTRY

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways

(2012) Lin Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

(2011) S. Rodriguez et al.   BLOOD

Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21

(2011) Yuehua Huang et al.   GASTROENTEROLOGY

Glypican-1 Stimulates Skp2 Autoinduction Loop and G1/S Transition in Endothelial Cells

(2011) Dianhua Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

New Bicyclo[3.1.0]hexane Unit ent-Kaurane Diterpene and Its seco-Derivative from Isodon eriocalyx var. laxiflora

(2011) Wei-Guang Wang et al.   ORGANIC LETTERS

Sense and Sensitivity: FOXO and ROS in Cancer Development and Treatment

(2010) Stephen S. Myatt et al.   ANTIOXIDANTS & REDOX SIGNALING

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

(2010) Feng-Hou Gao et al.   BMC CANCER

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway

(2010) Songgang Li et al.   CANCER LETTERS

Current approach in the treatment of hepatocellular carcinoma

(2010) Luigi Rossi   World Journal of Gastrointestinal Oncology

Ubiquitin-mediated control of oncogene and tumor suppressor gene products

(2009) Kyoko Kitagawa et al.   CANCER SCIENCE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY