Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin–proteasome pathway

Transforming acidic coiled-coil proteins (TACCs) in human cancer

(2013) Geun-Hyoung Ha et al.   CANCER LETTERS

Aurora A kinase and its substrate TACC3 are required for central spindle assembly

(2013) Antonios Lioutas et al.   EMBO REPORTS

Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding

(2013) Fiona E. Hood et al.   JOURNAL OF CELL BIOLOGY

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

(2013) Guangwu Guo et al.   NATURE GENETICS

A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells

(2013) R Yao et al.   ONCOGENE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Mitotic catastrophe and cell death induced by depletion of centrosomal proteins

(2013) M Kimura et al.   Cell Death & Disease

Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist

(2012) Yukihiro Itoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oncogenic FGFR3 gene fusions in bladder cancer

(2012) Sarah V. Williams et al.   HUMAN MOLECULAR GENETICS

Multiple Cancer Testis Antigens Function To Support Tumor Cell Mitotic Fidelity

(2012) K. M. Cappell et al.   MOLECULAR AND CELLULAR BIOLOGY

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

Development of target protein-selective degradation inducer for protein knockdown

(2011) Yukihiro Itoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

(2011) Yukihiro Itoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy

(2011) Yosuke Demizu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cdh1 controls the stability of TACC3

(2011) Jen-Chong Jeng et al.   CELL CYCLE

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

(2011) Daniel G Booth et al.   EMBO JOURNAL

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

(2011) Keiichiro Okuhira et al.   FEBS LETTERS

Disruption of Tacc3 function leads to in vivo tumor regression

(2011) R Yao et al.   ONCOGENE

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3

(2010) Nobumichi Ohoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability

(2010) Chiou-Hong Lin et al.   JOURNAL OF CELL BIOLOGY

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

(2010) W. Fu et al.   JOURNAL OF CELL SCIENCE

Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

(2010) Yukihiro Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

(2010) Lambertus A Kiemeney et al.   NATURE GENETICS

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program

(2010) S Schmidt et al.   ONCOGENE

A small molecule accelerates neuronal differentiation in the adult rat

(2010) H. Wurdak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation

(2008) Keiko Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY