Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes
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Title
Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes
Authors
Keywords
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Journal
Cell Death & Disease
Volume 4, Issue 10, Pages e818-e818
Publisher
Springer Nature
Online
2013-10-04
DOI
10.1038/cddis.2013.361
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Note: Only part of the references are listed.- Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation
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- Classes of Sigma2 (σ2) Receptor Ligands: Structure Affinity Relationship (SAfiR) Studies and Antiproliferative Activity
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- Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
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- Structural divergence of the rotary ATPases
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- The mechanism of rotating proton pumping ATPases
- (2010) Mayumi Nakanishi-Matsui et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine
- (2010) John R Hornick et al. Molecular Cancer
- Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
- (2009) Valerian E. Kagan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?
- (2009) Boris Turk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues
- (2008) Gabriela Droga-Mazovec et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High-Affinity Small Molecule−Phospholipid Complex Formation: Binding of Siramesine to Phosphatidic Acid
- (2008) Mikko J. Parry et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Substituted benzylaminoalkylindoles with preference for the σ2 binding site
- (2007) Maria Grazia Mamolo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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