Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging

IFN-  and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways

(2014) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Regulation of TOR by small GTPases

(2012) Raúl V Durán et al.   EMBO REPORTS

Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons

(2012) Stefanie C. Huelsenbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTPase Expression in Human Myeloid Cells

(2012) Suzanne F. G. van Helden et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity

(2012) Christian Henninger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

(2011) B. Mizukawa et al.   BLOOD

Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents

(2011) G. Fritz et al.   BRITISH MEDICAL BULLETIN

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

(2011) Hendrik Ungefroren et al.   Molecular Cancer

Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors

(2011) Melanie Hamalukic et al.   PLoS One

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

(2011) J Huelsenbeck et al.   Cell Death & Disease

Transforming human blood stem and progenitor cells: A new way forward in leukemia modeling

(2010) James C. Mulloy et al.   CELL CYCLE

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

(2010) Shuji Ueda et al.   FASEB JOURNAL

Pretreatment with Statin Attenuates the Cardiotoxicity of Doxorubicin in Mice

(2009) A. Riad et al.   CANCER RESEARCH

Importance of Rac1 Signaling Pathway Inhibition in the Pleiotropic Effects of HMG-CoA Reductase Inhibitors

(2009) Mamunur Rashid et al.   CIRCULATION JOURNAL

Differential Phosphorylation of RhoGDI Mediates the Distinct Cycling of Cdc42 and Rac1 to Regulate Second-phase Insulin Secretion

(2009) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

(2009) Masashi Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Topoisomerase II -dependent and -independent apoptotic effects of dexrazoxane and doxorubicin

(2009) T. Yan et al.   MOLECULAR CANCER THERAPEUTICS

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

(2009) Christian Ostrau et al.   RADIOTHERAPY AND ONCOLOGY

The Nuclear Import of the Small GTPase Rac1 is Mediated by the Direct Interaction with Karyopherin α2

(2009) Kirstin Sandrock et al.   TRAFFIC

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development

(2008) F. Guo et al.   BLOOD

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

P21-activated kinase is required for mitotic progression and regulates Plk1

(2008) B Maroto et al.   ONCOGENE

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

(2006) J Damrot et al.   BRITISH JOURNAL OF PHARMACOLOGY