Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells

(2014) E. Godebu et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Prevent Transfer of Type 1 Diabetes in NOD Mice Only When Their Antigen Is Present In Vivo

(2014) D. R. Tonkin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-  Are Resistant to Th17 Conversion by IL-6

(2014) S. G. Zheng et al.   JOURNAL OF IMMUNOLOGY

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells

(2011) Vanessa G. Oliveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

(2011) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

(2011) Guoyan Cheng et al.   IMMUNOLOGICAL REVIEWS

IL-7 uniquely maintains FoxP3+ adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization

(2011) Cheng-Rui Li et al.   JOURNAL OF AUTOIMMUNITY

Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children

(2011) Anette-G. Ziegler et al.   JOURNAL OF AUTOIMMUNITY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Quantitative events determine the differentiation and function of helper T cells

(2011) Anne O'Garra et al.   NATURE IMMUNOLOGY

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

(2011) Frank Waldron-Lynch et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical perspectives for regulatory T cells in transplantation tolerance

(2011) Keli L. Hippen et al.   SEMINARS IN IMMUNOLOGY

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

(2010) F. Vendrame et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Molecular Targeting of Islet Autoantigens

(2010) Brian Stadinski et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?

(2010) Xunrong Luo et al.   IMMUNITY

Interplay of transcription factors in T-cell differentiation and function: the role of Runx

(2010) Won Fen Wong et al.   IMMUNOLOGY

Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease

(2010) Xiaofeng Qian et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Generation and expansion of regulatory human CD4+ T-cell clones specific for pancreatic islet autoantigens

(2010) James A. Dromey et al.   JOURNAL OF AUTOIMMUNITY

Immune Modulation bySchistosoma mansoniAntigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems

(2010) Paola Zaccone et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

(2010) Matthias Merkenschlager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

(2010) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

(2010) M. Feuerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-β-dependent manner

(2009) Daniel R. Tonkin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional islet-specific Treg can be generated from CD4+CD25− T cells of healthy and type 1 diabetic subjects

(2009) S. Alice Long et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous Event

(2009) Greig P. Lennon et al.   IMMUNITY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF- 

(2009) P. L. Bollyky et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

(2009) Markus Feuerer et al.   NATURE IMMUNOLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Increased resistance to CD4+CD25hiregulatory T cell-mediated suppression in patients with type 1 diabetes

(2008) J. M. Lawson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

(2008) David A. Horwitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function

(2008) Ethan M. Shevach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

(2008) S. Alice Long et al.   JOURNAL OF AUTOIMMUNITY

The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice

(2008) Calliope A. Dendrou et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE