Review
Microbiology
Jiahuan Zhou, Jiayi Chen, Yunchi Peng, Yafeng Xie, Yongjian Xiao
Summary: Infectious diseases pose significant threats to human life, health, and economy. Serological diagnostic tests, based on detecting antigens or antibodies in body fluids, play a vital role in the diagnosis of infections. Epitopes, as key components in immune responses, can contribute to vaccine development, disease diagnosis, and stage determination. This article reviews the role of B cell epitopes in the clinical diagnosis of infectious diseases.
Review
Cell Biology
Jie Huang, Xinxin Chen, Xuekun Fu, Zheng Li, Yuhong Huang, Chao Liang
Summary: The discovery and identification of biomarkers are crucial for the advancement of medical diagnosis and therapeutics. Aptamers, as a potential technology for biomarker discovery, offer many advantages such as flexible design and easy synthesis, and have been successfully applied in CELL-SELEX and SOMAScan technologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yongshu Li, Winnie Wailing Tam, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu, Yunhua Gao
Summary: Biomarkers are detectable molecules that can indicate specific diseases, and nucleic acid aptamers have emerged as a powerful tool in biomarker discovery. SELEX-based methods have been developed to construct aptamers for discovering new biomarkers in different cell locations, and SOMAScan is a multiplexed protein biomarker detection technology. These methods have greatly accelerated biomarker discovery in various diseases.
BIOMARKER RESEARCH
(2023)
Article
Immunology
Si Liu, Yao Lu Zhang, Lu Yao Zhang, Guang Ju Zhao, Zhong Qiu Lu
Summary: This study identified FCGR2C as a potential immune biomarker associated with prognosis in sepsis, highlighting its potential as a target for immunotherapy to reduce sepsis mortality.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aileen See SiouNing, Tang Swee Seong, Hidehiro Kondo, Subha Bhassu
Summary: Infectious diseases pose a serious threat to aquaculture, resulting in high mortality and economic loss. MicroRNA plays a crucial role in regulating gene expression and various biological processes in aquatic organisms. Researchers have found that miRNAs can serve as biomarkers and biosensors for disease detection, and can also be used to develop vaccines. This review focuses on the regulatory mechanisms of miRNAs during infection in aquatic organisms, particularly their involvement in host immune responses and pathogen replication. The potential applications of miRNAs in diagnostics and treatments for the aquaculture industry are also explored.
Article
Clinical Neurology
Frederico Pieruccini-Faria, Sandra E. Black, Mario Masellis, Eric E. Smith, Quincy J. Almeida, Karen Z. H. Li, Louis Bherer, Richard Camicioli, Manuel Montero-Odasso
Summary: The study demonstrates that high gait variability is a marker of cognitive-cortical dysfunction, particularly in Alzheimer's disease dementia, and can help to accurately discriminate AD from other neurodegenerative and cognitive conditions.
ALZHEIMERS & DEMENTIA
(2021)
Review
Pharmacology & Pharmacy
Adam Bess, Frej Berglind, Supratik Mukhopadhyay, Michal Brylinski, Nicholas Griggs, Tiffany Cho, Chris Galliano, Kishor M. Wasan
Summary: Artificial intelligence and other in silico techniques can improve the efficiency and cost-effectiveness of drug discovery, and it is a crucial field for addressing emerging infectious diseases.
DRUG DISCOVERY TODAY
(2022)
Review
Immunology
Shun Yuan, Qi Wu, Zhiwei Wang, Yanjia Che, Sihao Zheng, Yuanyang Chen, Xiaohan Zhong, Feng Shi
Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
David A. Drew, Samuel J. Klempner, Andrew T. Chan
Summary: Early detection and interception of gastric cancer globally is limited, especially for individuals without established hereditary risk factors. Establishing biomarkers using multiple-omic approaches may be crucial for identifying individuals at risk and for more intensive evaluation. Multifactorial risk assessment is needed for precision prevention and early detection of gastric cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Ecology
Maxwell J. Farrell, Mohamad Elmasri, David A. Stephens, T. Jonathan Davies
Summary: This study predicts missing links in global mammal-parasite networks using available data and demonstrates how these predictions can guide the collection of interaction data, ultimately increasing the completeness of global species interaction networks. The study provides insights into the use of phylogenies for predicting host-parasite interactions and highlights the importance of iterated prediction and targeted search in collecting information on host-parasite interactions.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Chemistry, Applied
Lucile Lecas, Vincent Dugas, Claire Demesmay
Summary: Affinity chromatography, often overlooked in receptor/ligand studies, offers new perspectives with its simplicity and ability to provide diverse information. Different immobilization strategies have been developed to encompass a wide range of applications, from ligand-ranking to fragment screening and identification of active components from natural extracts.
SEPARATION AND PURIFICATION REVIEWS
(2021)
Article
Biochemical Research Methods
Ruiyun Li, Lu Yang, Su Guan, Ming Lin, Hanjin Lai, Kun Liu, Zimeng Liu, Xuyu Zhang
Summary: This study aimed to predict patients' sensitivity to propofol by screening metabolites and exploring metabolic pathways associated with propofol resistance. The glycerophospholipid metabolism pathway was identified as being influential in propofol response variability. Through metabolomics analysis, six potential biomarkers were discovered in an independent validation set, showing promise for predicting propofol sensitivity in patients.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
X. Chen, M. P. Kunasekaran, D. Hutchinson, H. Stone, T. Zhang, J. Aagerup, A. Moa, C. R. Macintyre
Summary: The study aimed to enhance the EPIRISK tool for accurately predicting the severity of COVID-19 in different countries. By modifying the original tool and adding parameters related to leadership, culture, and universal health coverage, the enhanced EPIRISK tool correctly predicted the risk levels of COVID-19 in different countries and historical outbreaks. This multifactorial tool can assist with early epidemic preparedness and prioritizing response to infectious disease outbreaks.
Review
Oncology
Gaetana Sessa, Asa Ehlen, Catharina von Nicolai, Aura Carreira
Summary: Variants of uncertain significance in the breast cancer susceptibility gene BRCA2 make up a significant portion of genetic testing results. Functional evaluation of these rare mutations may reveal novel activities of BRCA2 and suggest additional tests for accurate variant classification. Understanding the implications of these variants could lead to new clinical strategies for patients with BRCA2 mutations.
Review
Green & Sustainable Science & Technology
Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani, Hossein Faramarzi
Summary: Nanoparticles as antifungal drug delivery systems have unique advantages, such as increased anti-proliferative capacity, lower drug concentration requirements, and reduced negative effects.
Letter
Immunology
Jay V. Solnick
CLINICAL INFECTIOUS DISEASES
(2015)
Article
Medicine, General & Internal
Christopher R. Polage, Clare E. Gyorke, Michael A. Kennedy, Jhansi L. Leslie, David L. Chin, Susan Wang, Hien H. Nguyen, Bin Huang, Yi-Wei Tang, Lenora W. Lee, Kyoungmi Kim, Sandra Taylor, Patrick S. Romano, Edward A. Panacek, Parker B. Goodell, Jay V. Solnick, Stuart H. Cohen
JAMA INTERNAL MEDICINE
(2015)
Article
Microbiology
Kristof Moonens, Paer Gideonsson, Suresh Subedi, Jeanna Bugaytsova, Ema Romao, Melissa Mendez, Jenny Norden, Mahsa Fallah, Lena Rakhimova, Anna Shevtsova, Martina Lahmann, Gaetano Castaldo, Kristoffer Brannstrom, Fanny Coppens, Alvin W. Lo, Tor Ny, Jay V. Solnick, Guy Vandenbussche, Stefan Oscarson, Lennart Hammarstrom, Anna Arnqvist, Douglas E. Berg, Serge Muyldermans, Thomas Boren, Han Remaut
CELL HOST & MICROBE
(2016)
Article
Gastroenterology & Hepatology
Roberto M. Barrozo, Lori M. Hansen, Anna M. Lam, Emma C. Skoog, Miriam E. Martin, Lucy P. Cai, Yong Lin, Andreas Latoscha, Sebastian Suerbaum, Don R. Canfield, Jay V. Solnick
Article
Ecology
Bram Flahou, Mirko Rossi, Jaco Bakker, Jan A. M. Langermans, Edwin Heuvelman, Jay V. Solnick, Miriam E. Martin, Jani O'Rourke, Le Duc Ngoan, Nguyen Xuan Hoa, Masahiko Nakamura, Anders Overby, Hidenori Matsui, Hiroyoshi Ota, Takehisa Matsumoto, Dennis L. Foss, Laurice A. Kopta, Oladipo Omotosho, Maria Pia Franciosini, Patrizia Casagrande Proietti, Aizhen Guo, Han Liu, Gabriela Borilova, Ana Paula Bracarense, Sara K. Linden, Sofie De Bruyckere, Guangzhi Zhang, Chloe De Witte, Annemieke Smet, Frank Pasmans, Richard Ducatelle, Jukka Corander, Freddy Haesebrouck
Article
Microbiology
Emma C. Skoog, Vasilios A. Morikis, Miriam E. Martin, Greg A. Foster, Lucy P. Cai, Lori M. Hansen, Beibei Li, Jennifer A. Gaddy, Scott I. Simon, Jay V. Solnick
Article
Oncology
Sureyya Ozcan, Donald A. Barkauskas, L. Renee Ruhaak, Javier Torres, Cara L. Cooke, Hyun Joo An, Serenus Hua, Cynthia C. Williams, Lauren M. Dimapasoc, Jae Han Kim, Margarita Camorlinga-Ponce, David Rocke, Carlito B. Lebrilla, Jay V. Solnick
CANCER PREVENTION RESEARCH
(2014)
Article
Evolutionary Biology
Barbara Ottolini, Michael J. Hornsby, Razan Abujaber, Jacqueline A. L. MacArthur, Richard M. Badge, Trude Schwarzacher, Donna G. Albertson, Charles L. Bevins, Jay V. Solnick, Edward J. Hollox
GENOME BIOLOGY AND EVOLUTION
(2014)
Article
Microbiology
Mary E. Moore, Anna Lam, Srijak Bhatnagar, Jay V. Solnick
JOURNAL OF BACTERIOLOGY
(2014)
Article
Multidisciplinary Sciences
Mary E. Kable, Lori M. Hansen, Cathy M. Styer, Samuel L. Deck, Olena Rakhimova, Anna Shevtsova, Kathryn A. Eaton, Miriam E. Martin, Par Gideonsson, Thomas Boren, Jay V. Solnick
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Connie Fung, Shumin Tan, Mifuyu Nakajima, Emma C. Skoog, Luis Fernando Camarillo-Guerrero, Jessica A. Klein, Trevor D. Lawley, Jay V. Solnick, Tadashi Fukami, Manuel R. Amieva
Article
Microbiology
Emma C. Skoog, Miriam E. Martin, Roberto M. Barrozo, Lori M. Hansen, Lucy P. Cai, Seung-Joo Lee, Joseph M. Benoun, Stephen J. McSorley, Jay V. Solnick
Article
Education, Scientific Disciplines
Miriam E. Martin, Arik Davidyan
Summary: This report discusses the benefits of including undergraduate learning assistants in the teaching team of a course, as well as the challenges faced when some instructors had to temporarily discontinue or scale down their LA programs during emergency remote instruction. The case study presented can serve as a model for implementing a robust online LA program.
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION
(2021)
Article
Gastroenterology & Hepatology
Miriam E. Martin, Jay V. Solnick