Article
Food Science & Technology
Maria Romo, Massimo Castellari, Dinar Fartdinov, Xavier Felipe
Summary: In this study, high-pressure processing was used to remove beta-Lactoglobulin from bovine native whey concentrate and generate an enriched alpha-Lactalbumin fraction. The optimal conditions for alpha-Lactalbumin yield and purification degree were determined. The results showed that high-pressure processing could improve the precipitation of beta-Lactoglobulin and the purification of alpha-Lactalbumin. Further characterization and application of membrane concentration and high-pressure processing are recommended for the valorization of cheese whey.
Article
Food Science & Technology
Maria Romo, Massimo Castellari, Ricard Bou, Pere Gou, Xavier Felipe
Summary: Whey from goat and sheep are being studied for their nutritional properties, but the presence of beta-Lg in these whey sources may cause allergies in infants. Therefore, researchers are interested in developing whey ingredients with higher alpha-La/beta-Lg ratios. This study investigated the effect of high-pressure processing on goat and sheep native whey concentrates (NWC) to obtain alpha-La-enriched fractions. The results showed that high-pressure processing reduced the concentration of beta-Lg in NWC, while alpha-La concentration remained unchanged.
Article
Food Science & Technology
Serena Boscaini, Peter Skuse, Kanishka N. Nilaweera, John F. Cryan, Paul D. Cotter
Summary: This review provides an overview of the beneficial effects of whey protein (WP) and its components on human health, particularly in controlling obesity and its comorbidities. WP consumption positively impacts energy balance and obesity-related parameters, primarily through modulation in adipose tissue metabolism and changes that occur in the gastrointestinal tract. Furthermore, WP also has a positive impact on gut microbiota, mood, and behavior. This review emphasizes the importance of WP supplementation in preventing or treating obesity and highlights areas for further research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Thomas Valente De Oliveira, Marcelo Depolo Poleto, Samuel Vieira Barbosa, Jane Selia dos Reis Coimbra, Eduardo Basilio De Oliveira
Summary: Computational molecular dynamics was used to analyze the molecular conformations of bovine alpha-lactalbumin at different temperatures, showing that the absence of Ca2+ triggered significant protein conformation changes and affected the foaming properties. This study demonstrates the power of MD in providing insights into the molecular origins of food protein functionalities.
Article
Food Science & Technology
Andrea P. Cuevas-Gomez, Berenice Gonzalez-Magallanes, Izlia J. Arroyo-Maya, Gustavo F. Gutierrez-Lopez, Maribel Cornejo-Mazon, Humberto Hernandez-Sanchez
Summary: The stabilization of Pickering emulsions by nanoparticles has attracted interest in the field of food science and technology. This study used alpha-Lactalbumin nanoparticles to stabilize squalene-rich amaranth oil Pickering o/w emulsions and found that a concentration of 5-10% nanoparticles reached the critical coverage ratio and effectively stabilized the droplet size.
Article
Food Science & Technology
Kungnang Bunsroem, Witoon Prinyawiwatkul, Siwatt Thaiudom
Summary: This study evaluated the susceptibility of whey proteins to enzyme hydrolysis and the antidiabetic properties of protein hydrolysates. The results showed that alpha-LA hydrolysate was more effective than beta-LG hydrolysate in inhibiting DPP-W activity and increasing GLP-1 levels. Heat treatment at 75 degrees C had the greatest impact on the antidiabetic properties of the protein hydrolysates.
Article
Agriculture, Dairy & Animal Science
Nasser A. Al-Shabib, Javed Masood Khan, Ajamaluddin Malik, Md Tabish Rehman, Fohad Mabood Husain, Mohamed F. AlAjmi, Osama Hamdan Ali Alghamdi, Altaf Khan
Summary: The study found that the food dye quinoline yellow (QY) can induce amyloid fibrillation of alpha-lactalbumin (alpha-LA) at low pH conditions. This process is rapid and concentration-dependent, altering the secondary structure of alpha-LA from alpha-helices to cross-beta-sheets. Transmission electron microscopy confirmed the amyloid-like structure of the aggregated alpha-LA.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Brandon Carter, Larissa DiMarzo, Joice Pranata, David M. Barbano, MaryAnne Drake
Summary: The study aimed to measure whey protein removal from sweet whey using polymeric microfiltration membranes and compared the performance with ceramic membranes. Results showed that polymeric membranes achieved lower yield of whey protein isolate and higher yield of whey protein phospholipid concentrate compared to ceramic membranes, impacting total gross revenue and the ratio of market price between the two products. Economic engineering study is needed to determine the long-term processing costs and net revenue under various market conditions.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Kamila Puppel, Patrycja Staniszewska, Marcin Golebiewski, Jan Slosarz, Grzegorz Grodkowski, Pawel Solarczyk, Malgorzata Kunowska-Slosarz, Piotr Kostusiak, Beata Kuczynska, Tomasz Przysucha
Summary: This study demonstrates a relationship between whey protein concentrations and blood BHBA levels, serving as markers for diagnosing metabolic diseases. Differences in alpha-lactoalbumin and beta-lactoglobulin concentrations in milk were observed based on varying BHBA levels in cows.
Article
Food Science & Technology
Chen-Jie Ling, Xiao-Fang Chen, Jia-Ying Xu, Gui-Ping Wang, Yan Wang, Yue Sun, Yun-Liang Li, Zhong-Xiao Wan, Xing Tong, Khemayanto Hidayat, Wan-Zhan Zhu, Li-Qiang Qin, Jing Yang
Summary: Whey protein hydrolysates have good prospects in weight management for middle-aged individuals by reducing energy intake, slowing down weight gain, improving blood lipids and glucose, and enhancing muscle antioxidant capacity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Clara Fucinos, Natalia Estevez, Lorenzo Pastrana, Clara A. Tovar, Maria Luisa Rua
Summary: The bioactivity of α-lactalbumin was significantly improved by the synthesis of nanotubes, with higher ACE-inhibitory and antioxidant activity. Different ion ratios during nanotube synthesis altered the microstructure of α-lactalbumin nanotubes, resulting in varied rheological properties and structural regeneration capabilities.
FOOD HYDROCOLLOIDS
(2021)
Article
Genetics & Heredity
Anna Sadovnikova, Sergio C. Garcia, Josephine F. Trott, Alice T. Mathews, Monica T. Britton, Blythe P. Durbin-Johnson, Russell C. Hovey
Summary: Milk production by dairy cows is sensitive to stress hormones such as glucocorticoids (GC). This study found that exogenous dexamethasone (DEX) transiently suppresses milk yield in cows by reducing the synthesis of alpha-lactalbumin and lactose. RNA sequencing analysis identified changes in gene expression in the mammary glands in response to DEX.
FRONTIERS IN GENETICS
(2022)
Article
Nutrition & Dietetics
Ulrika Tinghaell Nilsson, Olle Hernell, Bo Lonnerdal, Merete Lindberg Hartvigsen, Lotte Neergaard Jacobsen, Anne Staudt Kvistgaard, Pia Karlsland Akeson
Summary: Protein intake in formula-fed infants is higher than in breast-fed infants, which may increase the risk of overweight. Adding alpha-lactalbumin-enriched whey or casein glycomacropeptide-reduced whey to formula can further reduce protein and improve amino acid balance. This study found that low-protein formulas enriched with alpha-lac-enriched whey or CGMP-reduced whey supported adequate growth, with similar weight gain to breast-fed infants and metabolic profiles closer to breast-fed infants.
Article
Food Science & Technology
Haoran Chen, Xiaofen Qi, Kaifang Guan, Yuxiang Gu, Rongchun Wang, Qiming Li, Ying Ma
Summary: The study showed that peptides from alpha-lactalbumin hydrolysate could improve lipid metabolism in HepG2 cells, with P2 and P8 being more effective in enhancing intracellular TG and PPAR alpha levels. These peptides acted as PPAR alpha ligands to regulate lipid metabolism-related gene expression, showing promise in ameliorating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Lina Zhang, Ruoya Zhou, Jinyue Zhang, Peng Zhou
Summary: Whey proteins, as the second most abundant protein in milk, contain many bioactive proteins that play important roles in consumer health. Heating treatments during dairy processing can lead to changes in the structure and bioactivity of whey proteins, which may impact the nutritional value and properties of dairy products.
INTERNATIONAL DAIRY JOURNAL
(2021)
Article
Nutrition & Dietetics
Reetta Holma, Reijo Laatikainen, Helena Orell, Heikki Joensuu, Katri Peuhkuri, Tuija Poussa, Riitta Korpela, Pia Osterlund
Article
Multidisciplinary Sciences
Stefania Noerman, Anton Klavus, Elina Jarvela-Reijonen, Leila Karhunen, Seppo Auriola, Riitta Korpela, Raimo Lappalainen, Urho M. Kujala, Sampsa Puttonen, Marjukka Kolehmainen, Kati Hanhineva
SCIENTIFIC REPORTS
(2020)
Review
Pharmacology & Pharmacy
Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: Inflammatory bowel diseases require new treatment options to control inflammation and fibrosis, and RAS inhibitors may be a cost-effective and effective alternative. While animal studies have shown the efficacy of RAS inhibitors in colitis, human data are still limited. Retrospective studies indicate that IBD patients using RAS inhibitors have a milder disease course and fewer hospitalizations.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elina Jarvela-Reijonen, Suvi Jarvinen, Leila Karhunen, Tiina Fohr, Tero Myllymaki, Essi Sairanen, Sanni Lindroos, Katri Peuhkuri, Maarit Hallikainen, Jussi Pihlajamaki, Sampsa Puttonen, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Urho M. Kujala, Marjukka Kolehmainen, Jaana Laitinen
Summary: The study found that better nocturnal recovery was associated with better diet quality, lower alcohol consumption, and possibly less intuitive eating.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuulia Onali, Anne Kivimaki, Matti Mauramo, Tuula Salo, Riitta Korpela
Summary: Wild berries such as lingonberry and bilberry are rich in phytochemicals and demonstrate anticancer effects on digestive tract cancers. Studies indicate that these berries inhibit tumor formation and cancer cell growth in colorectal cancer, supporting their potential as antiproliferative and antitumor agents.
Article
Medicine, Research & Experimental
Zan Pang, Hanna Launonen, Riitta Korpela, Heikki Vapaatalo
Summary: This study found that low sodium diet, dibutyryl-cAMP and Ang II can stimulate the local synthesis of aldosterone in the large intestine, similar to the adrenal glands.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hanna Launonen, Lotta Luiskari, Jere Linden, Aino Siltari, Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: In this study, we examined the effect of the aldosterone synthase inhibitor FAD286 on intestinal inflammation. Contrary to expectations, FAD286 did not inhibit intestinal aldosterone synthesis and even exacerbated the signs of inflammation, indicating its harmful effects.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Physiology
Z. Pang, R. Korpela, H. Vapaatalo
Summary: In this study, the presence of the complete aldosterone production process from precursor corticosterone to final product aldosterone was detected in the murine large intestine. The enzyme activity of CYP11B2, involved in aldosterone synthesis, was higher in the large intestine compared to the small intestine, and increased during the dark period in the ileum and colon. The highest concentration of aldosterone was detected in the large intestine during the dark period. Overall, this study highlights the widespread presence of CYP11B2 enzyme activity throughout the intestine, with higher aldosterone production occurring in the large intestine during the dark period, and no differences observed between early and late light hours.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Physiology
H. Launonen, Z. Pang, J. Linden, A. Siltari, R. Korpela, H. Vapaatalo
Summary: Aldosterone, the main mineralocorticoid, is synthesized from cholesterol in the adrenal cortex and regulates sodium and potassium balance. Recent studies show that aldosterone can be locally produced in tissues other than the adrenal cortex, such as the brain, heart, blood vessels, kidneys, and adipocytes. The research suggests that aldosterone may also be synthesized in the intestine.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Physiology
L. Varmavuori, H. Launonen, R. Korpela, H. Vapaatalo
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
L-U Suojanen, A. J. Ahola, S. Kupila, R. Korpela, K. H. Pietilainen
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Qingru Jiang, Veera Kainulainen, Iva Stamatova, Sok-Ja Janket, Jukka H. Meurman, Riitta Korpela
Article
Psychology, Clinical
Elina Jarvela-Reijonen, Sampsa Puttonen, Leila Karhunen, Essi Sairanen, Jaana Laitinen, Mikko Kolehmainen, Jussi Pihlajamaki, Urho M. Kujala, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Marjukka Kolehmainen
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2020)
Article
Physiology
L. Pasanen, H. Launonen, A. Siltari, R. Korpela, H. Vapaatalo, H. Salmenkari, R. A. Forsgard
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
Reijo Laatikainen, Jonna Jalanka, Jussi Loponen, Sanna-Maria Hongisto, Markku Hillila, Jari Koskenpato, Riitta Korpela, Anne Salonen
