Benzophenone: a ubiquitous scaffold in medicinal chemistry

Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation

(2018) Takayuki Wakaki et al.   ACS Catalysis

Synthesis of 4-substituted ethers of benzophenone and their antileishmanial activities

(2018) et al.   Royal Society Open Science

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C-H Arylations with Aryl Halides

(2017) Maddali L. N. Rao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Biological Evaluation of Benzophenone Derivatives as Potential HIV-1 Inhibitors

(2017) Zhendong Song et al.   Medicinal Chemistry

Synthesis and in vivo anti-hyperlipidemic activity of novel n-benzoylphenyl-2-furamide derivatives in Wistar rats

(2017) Suhair Hikmat et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Leishmaniasis in humans: drug or vaccine therapy?

(2017) Masoud Ghorbani et al.   Drug Design Development and Therapy

The Development and Application of Two-Chamber Reactors and Carbon Monoxide Precursors for Safe Carbonylation Reactions

(2016) Stig D. Friis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in Dalton’s lymphoma

(2016) Mohammed Al-Ghorbani et al.   BIOORGANIC CHEMISTRY

Design and synthesis of diamide-coupled benzophenones as potential anticancer agents

(2016) Zabiulla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzophenone-nucleoside derivatives as telomerase inhibitors: Design, synthesis and anticancer evaluation in vitro and in vivo

(2016) Jing Bo Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

(2015) Kohichi Kawahara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

(2015) Letícia de Almeida et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors

(2015) Jinyuk Heo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acylation of (Hetero)Arenes through CH Activation with Aroyl Surrogates

(2015) Xiao-Feng Wu   CHEMISTRY-A EUROPEAN JOURNAL

Transition-Metal-Catalyzed Oxidative and Decarboxylative Acylations through sp2 C-H Bond Activation

(2015) Satyasheel Sharma et al.   CURRENT ORGANIC CHEMISTRY

COX inhibitors: a patent review (2011 – 2014)

(2015) Sara Consalvi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

2,2′-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1

(2014) Fereniki D. Perperopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzophenones

(2014) Ashley R. Heurung et al.   Dermatitis

Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease

(2014) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural diversity and bioactivities of natural benzophenones

(2014) Shi-Biao Wu et al.   NATURAL PRODUCT REPORTS

Carbonylative Suzuki Couplings of Aryl Bromides with Boronic Acid Derivatives under Base-Free Conditions

(2014) Klaus M. Bjerglund et al.   ORGANIC LETTERS

Development of a New Benzophenone–Diketopiperazine-Type Potent Antimicrotubule Agent Possessing a 2-Pyridine Structure

(2014) Yoshiki Hayashi et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones

(2013) Claudia Mara Maciel-Rezende et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Synthesis, angiopreventive activity, and in vivo tumor inhibition of novel benzophenone–benzimidazole analogs

(2013) V. Lakshmi Ranganatha et al.   LIFE SCIENCES

Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability

(2013) Iris Usach et al.   Journal of the International AIDS Society

Recent developments in palladium catalysed carbonylation reactions

(2013) Sandip T. Gadge et al.   RSC Advances

Benzophenone Photosensitized DNA Damage

(2012) M. Consuelo Cuquerella et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vivo Antihyperlipidemic Activity of a New Series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats

(2012) Tariq Al-Qirim et al.   ARCHIV DER PHARMAZIE

Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton

(2012) Chang Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

(2012) Yuri Yamazaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones

(2012) Babasaheb P. Bandgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preparation of Benzoyloxy Benzophenone Derivatives and Their Inhibitory Effects of ICAM-1 Expression

(2012) Eun-Mi Kwon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

(2011) Xiao-Dong Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents

(2011) Mikhail S. Novikov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)ethanone Derivatives

(2011) Kambappa Vinaya et al.   Chemical Biology & Drug Design

Synthesis of biarylketones and phthalides from organoboronic acids and aldehydes catalyzed by cobalt complexes

(2011) Jaganathan Karthikeyan et al.   CHEMICAL COMMUNICATIONS

Update 1 of: Use of Solid Catalysts in Friedel−Crafts Acylation Reactions

(2011) Giovanni Sartori et al.   CHEMICAL REVIEWS

Palladium-catalyzed carbonylative coupling reactions between Ar–X and carbon nucleophiles

(2011) Xiao-Feng Wu et al.   CHEMICAL SOCIETY REVIEWS

Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

(2011) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites

(2011) Swetlana Heinrich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure–Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure

(2011) Yuri Yamazaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and pharmacokinetic profiling of benzophenone derivatives as tumor necrosis factor-alpha and interleukin-6 inhibitors

(2011) Babasaheb Bandgar et al.   MEDICINAL CHEMISTRY RESEARCH

Examination of a synthetic benzophenone membrane-targeted antibiotic

(2011) Sunil K. Vooturi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-α and IL-6 inhibitors with antioxidant activity

(2010) Babasaheb P. Bandgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

(2010) J. Román Luque-Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzophenones from the roots of the Popoluca Amerindian medicinal plant Securidaca diversifolia (L.) S.F. Blake

(2010) Laura Casu et al.   Phytochemistry Letters

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone

(2009) Mirko Altenkämper et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzophenone-N-ethyl piperidine ether analogues—Synthesis and efficacy as anti-inflammatory agent

(2009) Shaukath A. Khanum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyisoprenylated Benzophenones from Clusiaceae: Potential Drugs and Lead Compounds

(2009) Ulyana Acuna et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Solution-Phase Parallel Synthesis of Novel Membrane-Targeted Antibiotics

(2009) Sunil K. Vooturi et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

(2009) Sunil K. Vooturi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leishmanicidal activity of benzophenones and extracts from Garcinia brasiliensis Mart. fruits

(2009) I.O. Pereira et al.   PHYTOMEDICINE

Development of Benzophenone-Based Farnesyltransferase Inhibitors as Novel Antimalarials

(2008) Katja Kohring et al.   ChemMedChem

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

(2008) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Esters as Acylating Reagent in a Friedel−Crafts Reaction: Indium Tribromide Catalyzed Acylation of Arenes Using Dimethylchlorosilane

(2008) Yoshihiro Nishimoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids

(2007) Changming Qin et al.   TETRAHEDRON LETTERS