Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I

Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis

(2013) Jing Zhai et al.   ChemMedChem

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

(2012) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

(2012) Huifen Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain Penetrant LRRK2 Inhibitor

(2012) Hwan Geun Choi et al.   ACS Medicinal Chemistry Letters

Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons

(2011) Nigel Ramsden et al.   ACS Chemical Biology

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold

(2011) Ailing Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

(2011) Craig A. Zificsak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I

(2010) Ryoko Takasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

(2009) Maria A. Argiriadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis

(2009) Ming Liu et al.   BIOPHYSICAL CHEMISTRY

Structure–activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects

(2008) Ryoko Takasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA