Article
Neurosciences
Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvanen
Summary: The study investigated synaptic density in transgenic mouse models of Alzheimer's disease and Parkinson's disease using [C-11]UCB-J PET, suggesting that the PET imaging reflects synaptic density in mouse models of neurodegeneration with large inter-subject variation. Additionally, the study proposed that the model-independent AUCbrain/blood ratio can be used to evaluate [C-11]UCB-J binding as an alternative to full pharmacokinetic modeling.
Article
Multidisciplinary Sciences
Filipa Mota, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Daniel P. Holt, Patricia De Jesus, Martin A. Lodge, Clara Erice, Xueyi Chen, Melissa Bahr, Kelly Flavahan, John Kim, Mary Katherine Brosnan, Alvaro A. Ordonez, Charles A. Peloquin, Robert F. Dannals, Sanjay K. Jain
Summary: This study examines the penetration of Pretomanid, an antibiotic for drug-resistant tuberculosis, into the central nervous system. The findings show that Pretomanid has excellent penetration into the CNS, but bedaquiline and linezolid have limited penetration, leading to less efficacy in treating TB meningitis. These results have important implications for developing new antibiotic treatments for TB meningitis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Alexander P. Seiffert, Adolfo Gomez-Grande, Alberto Villarejo-Galende, Marta Gonzalez-Sanchez, Hector Bueno, Enrique J. Gomez, Patricia Sanchez-Gonzalez
Summary: Dynamic early-phase PET images using radiotracers binding to fibrillar amyloid-beta correlate with [F-18]fluorodeoxyglucose PET images and provide perfusion-like information. Regional standardized uptake value ratios and intrapatient Pearson's correlation coefficients show strong correlations between the dynamic early-phase PET images and [F-18]FDG PET images. This suggests that dynamic early-phase PET could serve as an additional neurodegeneration biomarker in amyloid PET studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth C. Mormino, Tyler N. Toueg, Carmen Azevedo, Jessica B. Castillo, Wanjia Guo, Ayesha Nadiadwala, Nicole K. Corso, Jacob N. Hall, Audrey Fan, Alexandra N. Trelle, Marc B. Harrison, Madison P. Hunt, Sharon J. Sha, Gayle Deutsch, Michelle James, Carolyn A. Fredericks, Mary Ellen Koran, Michael Zeineh, Kathleen Poston, Michael D. Greicius, Mehdi Khalighi, Guido A. Davidzon, Bin Shen, Greg Zaharchuk, Anthony D. Wagner, Frederick T. Chin
Summary: In vivo measurements using (18)F-PI-2620 PET scans revealed significant differences in brain regions associated with Alzheimer's disease across different stages of the disease. This indicates the potential of (18)F-PI-2620 as a tool for visualizing tau aggregations in AD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Raquel Sanchez-Varo, Marina Mejias-Ortega, Juan Jose Fernandez-Valenzuela, Cristina Nunez-Diaz, Laura Caceres-Palomo, Laura Vegas-Gomez, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan Antonio Garcia-Leon, Ines Moreno-Gonzalez, Marisa Vizuete, Javier Vitorica, David Baglietto-Vargas, Antonia Gutierrez
Summary: This review provides an overview of the major pathological elements of Alzheimer's disease and discusses the insights provided by mouse models in understanding the underlying mechanisms. It highlights the pros and cons of current models and explores the potential benefits of combining transgenic mice with omics technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
William Charles Kreisl, Patrick J. Lao, Aubrey Johnson, Zeljko Tomljanovic, Julia Klein, Krista Polly, Benjamin Maas, Krystal K. Laing, Anthony G. Chesebro, Kay Igwe, Qolamreza R. Razlighi, Lawrence S. Honig, Xinyu Yan, Seonjoo Lee, Akiva Mintz, Jose A. Luchsinger, Yaakov Stern, D. P. Devanand, Adam M. Brickman
Summary: F-18-MK-6240 showed good correlation with CSF tau and p-tau levels, as well as age, cognition, and amyloid-based AD biomarkers. The study also found that F-18-MK-6240 binding patterns were associated with specific cognitive impairments in amyloid-positive participants, reflecting the progression of AD pathology.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Zhou, Hoon Choi, Jianbo Cao, Austin Pantel, Mamta Gupta, Hsiaoju S. Lee, David Mankoff
Summary: In this study, F-18-fluciclovine was investigated as a PET imaging biomarker for detecting the pharmacodynamic response to the glutaminase inhibitor (GLSi). The results showed that F-18-fluciclovine uptake was mediated by glutamine transporters and an increase in distribution volume (V-D) was observed after GLSi treatment in TNBC models with high glutaminase activity. F-18-fluciclovine PET has the potential to serve as a clinically translatable pharmacodynamic biomarker of GLSi.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Huan-Chun Lin, Kun-Ju Lin, Kuo-Lun Huang, Shih-Hsin Chen, Tsung-Ying Ho, Chin-Chang Huang, Jung-Lung Hsu, Chiung-Chih Chang, Ing-Tsung Hsiao
Summary: This study proposed a method for visually interpreting tau-PET using the [F-18] Florzolotau tracer and investigated its performance and utility. The visual reading method generated a visual score with good sensitivity and specificity to identify AD-D or CU individuals from other patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Edmond Teng, Paul T. Manser, Sandra Sanabria Bohorquez, Kristin R. Wildsmith, Karen Pickthorn, Suzanne L. Baker, Michael Ward, Geoffrey A. Kerchner, Robby M. Weimer
Summary: This study evaluated the relationship between tau PET imaging and subsequent cognitive decline in Alzheimer's disease. The results indicated that higher baseline tau PET signal was associated with faster rates of cognitive decline. Tau PET imaging may be useful for identifying AD patients at risk for more rapid cognitive decline.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Neurosciences
Baosheng Chen, Bernadette Marquez-Nostra, Erika Belitzky, Takuya Toyonaga, Jie Tong, Yiyun Huang, Zhengxin Cai
Summary: This study reviews the current state of preclinical PET imaging using animal models of Alzheimer's disease (AD), highlighting its importance in understanding AD pathogenesis/progression and the development of novel treatments. Future research directions are also suggested.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolas J. Guehl, Maeva Dhaynaut, Bernard J. Hanseeuw, Sung-Hyun Moon, Cristina Lois, Emma Thibault, Jessie Fanglu Fu, Julie C. Price, Keith A. Johnson, Georges El Fakhri, Marc D. Normandin
Summary: This study investigated the use of [18F]MK6240 to derive a useful index of cerebral perfusion. The results showed that early-phase brain images provided valuable information about cerebral perfusion and were highly consistent with [11C]PiB results. Therefore, both the early and late phases of [18F]MK6240 dynamic acquisition can offer complementary information about the pathophysiological mechanisms of the disease.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anthony-David T. Campoy, Christopher Liang, Reisha M. Ladwa, Krystal K. Patel, Ishani H. Patel, Jogeshwar Mukherjee
Summary: This study reported the binding of [F-18]nifene to nAChRs in Parkinson's disease using a transgenic mouse model and postmortem human brain sections. Improved radiosynthesis methods and PET/CT procedures in mice were developed to establish optimal imaging time and observe decreases in [F-18]nifene binding both in vivo and in vitro. Confirmation of Lewy bodies and alpha-synuclein aggregates in human PD brain sections further supported the potential of [F-18]nifene as a valuable tool for PET imaging studies of PD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, Valentina Garibotto, John O. Prior, Henryk Barthel, Rui Zhou, Haifeng Hou, Xiaofeng Dou, Chentao Jin, Chuantao Zuo, Hong Zhang
Summary: This international consensus aims to help nuclear medicine practitioners perform F-18-flortaucipir PET imaging in patients with cognitive impairment. It will promote the standardized use of F-18-flortaucipir PET and become an international standard in clinical practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Microbiology
Jianhao Lai, Swati Shah, Rekeya Knight, Neysha Martinez-Orengo, Reema Patel, Amelia Mitchell, Zeping Wang, Falguni Basuli, Alvaro A. Ordonez, Sanjay K. Jain, Dima A. Hammoud
Summary: The diagnosis of fungal infections, especially with Aspergillus fumigatus, is still challenging. The study found low uptake of the newly described Enterobacterales imaging ligand FDS by A. fumigatus, suggesting that FDS is not a suitable imaging agent for Aspergillus.
Article
Biochemistry & Molecular Biology
Gausiha Rathitharan, Jennifer Truong, Junchao Tong, Tina McCluskey, Jeffrey H. Meyer, Romina Mizrahi, Jerry Warsh, Pablo Rusjan, James L. Kennedy, Sylvain Houle, Stephen J. Kish, Isabelle Boileau
Summary: Research on the brains of chronic MA users suggests that while there is activation of microglial cells, there is no significant increase in microgliosis. This indicates that microglia may not be a substantial therapeutic target for MA addiction, despite their involvement in MA-seeking behavior.
Article
Biochemistry & Molecular Biology
Maya R. Jacobson, Jeremy J. Watts, Tania Da Silva, Rachel F. Tyndale, Pablo M. Rusjan, Sylvain Houle, Alan A. Wilson, Ruth A. Ross, Isabelle Boileau, Romina Mizrahi
Summary: Lower levels of FAAH enzyme were found in the brains of adult cannabis users during early abstinence, with higher cannabis use throughout the past year correlating with decreased [C-11]CURB binding. The study also detected lower [C-11]CURB binding in a younger cohort with less cumulative cannabis exposure, confirming and extending previous findings.
Article
Psychiatry
Nathan J. Kolla, Isabelle Boileau, Karolina Karas, Jeremy J. Watts, Pablo Rusjan, Sylvain Houle, Romina Mizrahi
Summary: Individuals with ASPD have lower FAAH density in the amygdala, while FAAH expression in the cerebellum and striatum is inversely related to impulsivity. Cerebellar FAAH density is also negatively associated with assaultive aggression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Marion Criaud, Jin-Hee Kim, Mateusz Zurowski, Nancy Lobaugh, Sofia Chavez, Sylvain Houle, Antonio P. Strafella
Summary: The study found that anxiety symptoms in Parkinson's disease patients are associated with over-activation of the amygdala and impaired inter-relationship among regions involved in behavior and motor control.
Article
Multidisciplinary Sciences
Guiyang Hao, Tara Mastren, William Silvers, Gedaa Hassan, Orhan K. Oz, Xiankai Sun
Summary: The study explores the feasibility of using Cu-67-labeled antibodies for cancer radioimmunotheranostics, demonstrating significant improvements in radiolabeling efficiency with the use of pertuzumab and achieving promising results in preclinical therapeutic studies.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Duncan G. J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
Summary: This study revealed a negative correlation between levels of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) in the amygdala and functional connectivity in frontoamygdalar circuits involved in stress and affect control. The findings provide preliminary evidence supporting the role of FAAH in regulating brain circuits underlying fear and emotion processing in humans.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Correction
Neurosciences
J. Kolla Nathan, R. Mizrahi, K. Karas, C. Wang, R. M. Bagby, S. McMain, A. I. Simpson, P. M. Rusjan, R. Tyndale, S. Houle, I. Boileau
Summary: The correction to this paper has been published.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Patricia Di Ciano, Harriet de Wit, Esmaeil Mansouri, Sylvain Houle, Isabelle Boileau, Bernard Le Foll
Summary: PET imaging with [C-11]-(+)-PHNO was used to measure changes in dopamine levels in regions of interest in smokers who had maintained abstinence for 7-10 days. Results showed that smoking cues did not increase craving, and there were no significant changes in dopamine binding potential in most regions except for a decrease in the substantia nigra. Further research with a larger sample size is needed to validate these preliminary findings.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Sophia Attwells, Elaine Setiawan, Pablo M. Rusjan, Cynthia Xu, Stephen J. Kish, Neil Vasdev, Sylvain Houle, Apitharani Santhirakumar, Jeffrey H. Meyer
Summary: Oral minocycline did not significantly reduce TSPO V-T in TRD patients, suggesting that this dosage may be insufficient for reducing gliosis in this condition. Alternative therapeutic approaches or intravenous formulations of minocycline should be considered for targeting gliosis in TRD. Additionally, it should not be assumed that oral minocycline will reduce TSPO V-T or gliosis in humans without empirical evidence.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Talwinder Gill, Sarah E. Watling, J. Don Richardson, Tina McCluskey, Junchao Tong, Jeffrey H. Meyer, Jerry Warsh, Rakesh Jetly, Michael G. Hutchison, Shawn G. Rhind, Sylvain Houle, Neil Vasdev, Stephen J. Kish, Isabelle Boileau
Summary: Posttraumatic stress disorder (PTSD) may be associated with astrocyte pathology and a decrease in MAO-B levels. Preliminary results suggest a potential reduction in [C-11]SL25.1188 availability in PTSD patients, especially those with comorbid major depressive disorder (MDD). These findings are partly consistent with preclinical studies and recent PET observations, but further replication in a larger PTSD cohort is needed.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joseph A. Frankl, Yu An, Amber Sherwood, Guiyang Hao, Feng-Yun Huang, Pawan Thapa, Deborah J. Clegg, Xiankai Sun, Philipp E. Scherer, Orhan K. Oz
Summary: Obesity is a leading cause of preventable death and morbidity. This study finds that imaging BAT with the radioiodinated fatty acid analogue BMIPP yields more physiologically relevant data than FDG-PET/CT and may be a pivotal tool for evaluating BAT in both mice and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sashi Debnath, Guiyang Hao, Bing Guan, Pawan Thapa, Justin Hao, Hans Hammers, Xiankai Sun
Summary: Researchers have developed a novel small-molecule prodrug conjugate for targeted delivery and controlled release of toll-like receptor 7 (TLR7) agonists. In vitro and in vivo experiments demonstrated the specificity and stability of the conjugate, highlighting its potential for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Anna Vasilevskaya, Foad Taghdiri, Namita Multani, Miracle Ozzoude, Apameh Tarazi, Mozhgan Khodadadi, Richard Wennberg, Pablo Rusjan, Sylvain Houle, Robin Green, Brenda Colella, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, David Mikulis, Lili-Naz Hazrati, Gabor G. Kovacs, Karen Deborah Davis, Charles Tator, Maria Carmela Tartaglia
Summary: This study investigated the use of plasma pTau181 as a non-invasive measure to assess the risk of neurodegenerative diseases in retired athletes. The results showed that retired athletes had higher levels of plasma pTau181 and its levels were associated with abnormalities in certain brain regions. However, baseline pTau181 levels were not predictive of longitudinal changes in brain volumes or white-matter integrity in the athletes.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Jeremy J. Watts, Elisa Guma, Sofia Chavez, Rachel F. Tyndale, Ruth A. Ross, Sylvain Houle, Alan A. Wilson, Mallar Chakravarty, Pablo M. Rusjan, Romina Mizrahi
Summary: Dysregulation of hippocampus neurotransmission and volume has been associated with psychiatric disorders, and anandamide and FAAH are related to normal hippocampus function.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Sarah E. Watling, Samantha Jagasar, Tina McCluskey, Jerry Warsh, Shawn G. Rhind, Peter Truong, Sofia Chavez, Sylvain Houle, Junchao Tong, Stephen J. Kish, Isabelle Boileau
Summary: Preliminary data suggests that chronic methamphetamine (MA) use may cause oxidative stress and inflammation in the brain. This study aimed to investigate the levels of the antioxidant glutathione (GSH) in the brains of chronic MA users and explore the relationship between peripheral immunoinflammatory biomarkers and brain GSH concentrations. The results showed that GSH levels did not differ between MA users and healthy controls, but several immunoinflammatory biomarkers were significantly elevated in MA users and correlated with brain GSH levels.
FRONTIERS IN PSYCHIATRY
(2023)
