Journal
MEDCHEMCOMM
Volume 2, Issue 7, Pages 661-665Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00102g
Keywords
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Funding
- AntiMal [LSHP-CT-2005-0188]
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A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.
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