Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

Optimization of arylindenopyrimidines as potent adenosine A2A/A1 antagonists

(2010) Brian C. Shook et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists

(2010) Brian C. Shook et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vivo Characterization of a Dual Adenosine A2A/A1Receptor Antagonist in Animal Models of Parkinson’s Disease

(2010) Brian C. Shook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists

(2009) Yuefei Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A reassessment of risks and benefits of dopamine agonists in Parkinson's disease

(2009) Angelo Antonini et al.   LANCET NEUROLOGY

Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives

(2008) Roger J. Gillespie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines

(2008) Bernard R. Neustadt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dopamine agonists in Parkinson’s disease

(2008) Mitsutoshi Yamamoto et al.   Expert Review of Neurotherapeutics

Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2AReceptor Antagonists with In Vivo Efficacy

(2008) Deborah H. Slee et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Amino-N-pyrimidin-4-ylacetamides as A2AReceptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents

(2008) Deborah H. Slee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine in the central nervous system: release mechanisms and extracellular concentrations

(2003) Serena Latini et al.   JOURNAL OF NEUROCHEMISTRY