Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors

Neuronal Nicotinic Acetylcholine Receptors - Targets for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimers Disease

(2010) Simon Haydar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification

(2010) Jeroen Kool et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Insight in nAChR subtype selectivity from AChBP crystal structures

(2009) Prakash Rucktooa et al.   BIOCHEMICAL PHARMACOLOGY

Transforming fragments into candidates: small becomes big in medicinal chemistry

(2009) Gerdien E. de Kloe et al.   DRUG DISCOVERY TODAY

Comparison of Molecular Fingerprint Methods on the Basis of Biological Profile Data

(2009) Andreas Steffen et al.   Journal of Chemical Information and Modeling

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia

(2009) Segev Barak et al.   NEUROPSYCHOPHARMACOLOGY

Nicotinic receptors, allosteric proteins and medicine

(2008) Jean-Pierre Changeux et al.   TRENDS IN MOLECULAR MEDICINE