ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Dendritic spine actin cytoskeleton in autism spectrum disorder

(2018) Merja Joensuu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Dendritic spine actin dynamics in neuronal maturation and synaptic plasticity

(2016) Iryna Hlushchenko et al.   Cytoskeleton

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

Identification of an elaborate complex mediating postsynaptic inhibition

(2016) A. Uezu et al.   SCIENCE

Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

(2016) Francesco Petrelli et al.   Frontiers in Cellular Neuroscience

Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors

(2015) Magdalena Kalinowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

Excitatory/inhibitory imbalance in autism spectrum disorders: Implications for interventions and therapeutics

(2015) Genoveva Uzunova et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Myosin IIb controls actin dynamics underlying the dendritic spine maturation

(2014) Mikko Koskinen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Integrated systems analysis reveals a molecular network underlying autism spectrum disorders

(2014) J. Li et al.   Molecular Systems Biology

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Enhanced synapse remodelling as a common phenotype in mouse models of autism

(2014) Masaaki Isshiki et al.   Nature Communications

The Switch-associated Protein 70 (SWAP-70) Bundles Actin Filaments and Contributes to the Regulation of F-actin Dynamics

(2013) Carlos Andrés Chacón-Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myo9b and RICS Modulate Dendritic Morphology of Cortical Neurons

(2012) Hui Long et al.   CEREBRAL CORTEX

Cellular and synaptic network defects in autism

(2012) João Peça et al.   CURRENT OPINION IN NEUROBIOLOGY

The cellular function of srGAP3 and its role in neuronal morphogenesis

(2012) Claire Bacon et al.   MECHANISMS OF DEVELOPMENT

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex

(2012) Jerry L. Chen et al.   NEURON

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

(2011) Gene J. Blatt et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

WRP/srGAP3 Facilitates the Initiation of Spine Development by an Inverse F-BAR Domain, and Its Loss Impairs Long-Term Memory

(2011) B. R. Carlson et al.   JOURNAL OF NEUROSCIENCE

Regulation of Synapse Structure and Function by Distinct Myosin II Motors

(2011) M. D. Rubio et al.   JOURNAL OF NEUROSCIENCE

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Myosin IIB Activity and Phosphorylation Status Determines Dendritic Spine and Post-Synaptic Density Morphology

(2011) Jennifer L. Hodges et al.   PLoS One

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Rapid spine stabilization and synaptic enhancement at the onset of behavioural learning

(2010) Todd F. Roberts et al.   NATURE

Myosin IIb Regulates Actin Dynamics during Synaptic Plasticity and Memory Formation

(2010) Christopher S. Rex et al.   NEURON

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

(2009) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system

(2009) Claire Bacon et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

(2009) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field ofFmr1knockout mice

(2008) Yair Pilpel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images

(2008) Alfredo Rodriguez et al.   PLoS One