Visualization of cyclic nucleotide dynamics in neurons

NMDA Receptor-Dependent LTD Is Required for Consolidation But Not Acquisition of Fear Memory

(2014) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Engineering adenylate cyclases regulated by near-infrared window light

(2014) M.-H. Ryu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

(2014) Rajesh Jayachandran et al.   PLOS BIOLOGY

A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacteriumMicrocoleus chthonoplastesPCC 7420

(2013) Sarah Raffelberg et al.   BIOCHEMICAL JOURNAL

Transgenic Mice for cGMP Imaging

(2013) Martin Thunemann et al.   CIRCULATION RESEARCH

Novel approaches to drug design for the treatment of schizophrenia

(2013) Antoine Taly   Expert Opinion on Drug Discovery

Single-fluorophore biosensors based on conformation-sensitive GFP variants

(2013) Agnès Bonnot et al.   FASEB JOURNAL

Can we decipher the information content contained within cyclic nucleotide signals?

(2013) Thomas C. Rich et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanisms of cyclic AMP compartmentation revealed by computational models

(2013) Jeffrey J. Saucerman et al.   JOURNAL OF GENERAL PHYSIOLOGY

Striatal neurones have a specific ability to respond to phasic dopamine release

(2013) Liliana R. V. Castro et al.   JOURNAL OF PHYSIOLOGY-LONDON

The roles of protein kinases in learning and memory

(2013) K. P. Giese et al.   LEARNING & MEMORY

Near-infrared fluorescent proteins for multicolor in vivo imaging

(2013) Daria M Shcherbakova et al.   NATURE METHODS

GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

(2013) Aaron Marley et al.   PLoS One

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

(2013) Jessica L. Esseltine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

(2013) Marina Polito et al.   Frontiers in Cellular Neuroscience

Early Events in Axon/Dendrite Polarization

(2012) Pei-lin Cheng et al.   Annual Review of Neuroscience

Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation

(2012) A. del Puerto et al.   JOURNAL OF CELL SCIENCE

Parallel tracking of cAMP and PKA signaling dynamics in living cells with FRET-based fluorescent biosensors

(2012) Nwe-Nwe Aye-Han et al.   Molecular BioSystems

Minimum set of mutations needed to optimize cyan fluorescent proteins for live cell imaging

(2012) Marie Erard et al.   Molecular BioSystems

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

(2012) Vedangi Sample et al.   Nature Chemical Biology

The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

(2012) Rajeevan Selvaratnam et al.   PLoS One

Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luminescent proteins for high-speed single-cell and whole-body imaging

(2012) Kenta Saito et al.   Nature Communications

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Subcellular Location of PKA Controls Striatal Plasticity: Stochastic Simulations in Spiny Dendrites

(2012) Rodrigo F. Oliveira et al.   PLoS Computational Biology

Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells

(2011) Robert H. Newman et al.   CHEMICAL REVIEWS

Direct Activation of Epac by Sulfonylurea Is Isoform Selective

(2011) Katie J. Herbst et al.   CHEMISTRY & BIOLOGY

Semaphorin3A Regulates Neuronal Polarization by Suppressing Axon Formation and Promoting Dendrite Growth

(2011) Maya Shelly et al.   NEURON

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range

(2011) Jeffrey B. Klarenbeek et al.   PLoS One

Spatial and temporal second messenger codes for growth cone turning

(2011) X. Nicol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling of spatially-restricted intracellular signaling

(2011) Susana R. Neves   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications

(2010) Min-Hyung Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil BacteriumBeggiatoa

(2010) Manuela Stierl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 4 Phosphodiesterase Plays Different Integrating Roles in Different Cellular Domains in Pyramidal Cortical Neurons

(2010) L. R. V. Castro et al.   JOURNAL OF NEUROSCIENCE

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit

(2010) Qiang Ni et al.   Nature Chemical Biology

Blue Fluorescent cGMP Sensor for Multiparameter Fluorescence Imaging

(2010) Yusuke Niino et al.   PLoS One

The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations

(2010) Rodrigo F. Oliveira et al.   PLoS One

Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

(2010) M. Shelly et al.   SCIENCE

The structure and function of fluorescent proteins

(2009) Vedangi Sample et al.   CHEMICAL SOCIETY REVIEWS

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

(2009) R. P. Norris et al.   DEVELOPMENT

The role of membrane microdomains in shaping β2-adrenergic receptor-mediated cAMP dynamics

(2009) Lisa M. DiPilato et al.   Molecular BioSystems

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

(2009) Deanna L Wallace et al.   NATURE NEUROSCIENCE

Simultaneous Live Cell Imaging Using Dual FRET Sensors with a Single Excitation Light

(2009) Yusuke Niino et al.   PLoS One

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

(2009) C.-L. Zhang et al.   SCIENCE

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

The GAF Domain of the cGMP-Binding, cGMP-Specific Phosphodiesterase (PDE5) Is a Sensor and a Sink for cGMP†

(2008) Kabir Hassan Biswas et al.   BIOCHEMISTRY

Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks

(2008) Susana R. Neves et al.   CELL