MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

MeCP2 Phosphorylation Limits Psychostimulant-Induced Behavioral and Neuronal Plasticity

(2014) J. V. Deng et al.   JOURNAL OF NEUROSCIENCE

Rett syndrome and the urge of novel approaches to study MeCP2 functions and mechanisms of action

(2014) Francesco Bedogni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development

(2013) Ju Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome

(2013) S. K. Garg et al.   JOURNAL OF NEUROSCIENCE

Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project

(2013) Takashi Shiromizu et al.   JOURNAL OF PROTEOME RESEARCH

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

(2013) M. Courcelles et al.   Molecular Systems Biology

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

(2013) Daniel H. Ebert et al.   NATURE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum

(2013) Alessandro Ciccarelli et al.   NEUROPHARMACOLOGY

Ubiquitin System: Direct Effects Join the Signaling

(2013) A. L. Chernorudskiy et al.   Science Signaling

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

A Quantitative Map of the Liver Mitochondrial Phosphoproteome Reveals Posttranslational Control of Ketogenesis

(2012) Paul A. Grimsrud et al.   Cell Metabolism

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

(2012) Loredana Zocchi et al.   Epigenetics

Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows

(2012) Hélène Cheval et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of MeCP2 at Ser421 Contributes to Chronic Antidepressant Action

(2012) A. N. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

(2012) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Global Identification and Characterization of BothO-GlcNAcylation and Phosphorylation at the Murine Synapse

(2012) Jonathan C. Trinidad et al.   MOLECULAR & CELLULAR PROTEOMICS

Investigation of Receptor interacting protein (RIP3)-dependent Protein Phosphorylation by Quantitative Phosphoproteomics

(2012) Xiurong Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

(2012) M. L. Gonzales et al.   MOLECULAR AND CELLULAR BIOLOGY

The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity

(2012) Elisa S Na et al.   NEUROPSYCHOPHARMACOLOGY

Elevated IKKα Accelerates the Differentiation of Human Neuronal Progenitor Cells and Induces MeCP2-Dependent BDNF Expression

(2012) Ali Khoshnan et al.   PLoS One

Comparative phosphoproteomic analysis of neonatal and adult murine brain

(2012) Tapasree Goswami et al.   PROTEOMICS

Hippocampal CA1 Pyramidal Neurons ofMecp2Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

(2012) Christopher A. Chapleau et al.   NEURAL PLASTICITY

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells

(2011) Christoph Weber et al.   Journal of Proteomics

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic and phosphoproteomic comparison of human ES and iPS cells

(2011) Douglas H Phanstiel et al.   NATURE METHODS

Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

(2011) Hongda Li et al.   NATURE NEUROSCIENCE

Cocaine increases phosphorylation of MeCP2 in the rat striatum in vivo: A differential role of NMDA receptors

(2011) Li-Min Mao et al.   NEUROCHEMISTRY INTERNATIONAL

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Gokhan Demirkan et al.   PLoS One

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome

(2011) Silvia Landi et al.   Scientific Reports

Exploring the Human Leukocyte Phosphoproteome Using a Microfluidic Reversed-Phase−TiO2−Reversed-Phase High-Performance Liquid Chromatography Phosphochip Coupled to a Quadrupole Time-of-Flight Mass Spectrometer

(2010) Reinout Raijmakers et al.   ANALYTICAL CHEMISTRY

Rett syndrome: Revised diagnostic criteria and nomenclature

(2010) Jeffrey L. Neul et al.   ANNALS OF NEUROLOGY

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

(2010) Steven W. Long et al.   BIOSCIENCE REPORTS

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration

(2010) Jeremy H. Herskowitz et al.   JOURNAL OF PROTEOME RESEARCH

An Informatics-assisted Label-free Quantitation Strategy that Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion

(2010) Yi-Ting Wang et al.   JOURNAL OF PROTEOME RESEARCH

Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology

(2010) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers

(2010) Anton B. Iliuk et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists

(2010) Gitte L. Christensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags

(2010) Jessica E Rexach et al.   Nature Chemical Biology

MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants

(2010) Jie V Deng et al.   NATURE NEUROSCIENCE

Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor–dependent signaling pathways in renal collecting duct cells

(2010) Markus M. Rinschen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches

(2009) Laura Ricceri et al.   BEHAVIOURAL PHARMACOLOGY

MeCP2 post-translational regulation through PEST domains: two novel hypotheses

(2009) Anita A. Thambirajah et al.   BIOESSAYS

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells

(2009) R.-q. Chen et al.   CANCER RESEARCH

Severe congenital encephalopathy caused by MECP2 null mutations in males: central hypoxia and reduced neuronal dendritic structure

(2009) B Schüle et al.   CLINICAL GENETICS

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

(2009) Giorgia Bracaglia et al.   EMBO REPORTS

Early postnatal behavioral changes in theMecp2-308 truncation mouse model of Rett syndrome

(2009) B. De Filippis et al.   GENES BRAIN AND BEHAVIOR

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Comprehensive Mapping of Post-Translational Modifications on Synaptic, Nuclear, and Histone Proteins in the Adult Mouse Brain

(2009) Ry Y. Tweedie-Cullen et al.   JOURNAL OF PROTEOME RESEARCH

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

(2009) Nadia P. Belichenko et al.   NEUROBIOLOGY OF DISEASE

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

(2009) Christopher A. Chapleau et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Complications in the Assignment of 14 and 28 Da Mass Shift Detected by Mass Spectrometry as in Vivo Methylation from Endogenous Proteins

(2008) Sung Yun Jung et al.   ANALYTICAL CHEMISTRY

Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice

(2008) D. G.M. Jugloff et al.   HUMAN MOLECULAR GENETICS

Solid Tumor Proteome and Phosphoproteome Analysis by High Resolution Mass Spectrometry

(2008) Sara Zanivan et al.   JOURNAL OF PROTEOME RESEARCH

Phosphorylation Analysis of Primary Human T Lymphocytes Using Sequential IMAC and Titanium Oxide Enrichment

(2008) Montserrat Carrascal et al.   JOURNAL OF PROTEOME RESEARCH

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE