Article
Neurosciences
Florian Rebeillard, Stephanie De Gois, Nicolas Pietrancosta, Thi Hue Mai, Rene Lai-Kuen, Brigitte L. Kieffer, Bruno Giros, Renaud Massart, Michele Darmon, Jorge Diaz
Summary: GPR88 is highly expressed in striatal medium spiny neurons and has an atypical intranuclear localization in cortical neurons. It interacts with nuclear proteins ATRX, TOP2B, and BAZ2B involved in chromatin remodeling.
Article
Biochemistry & Molecular Biology
Eleonore W. E. Verweij, Reggie Bosma, Meichun Gao, Jelle van den Bor, Betty Al Araaj, Sabrina M. de Munnik, Xiaoyuan Ma, Rob Leurs, Henry F. Vischer
Summary: This study used bioluminescence resonance energy transfer (BRET)-based biosensors to measure the effects of different agonists on the H1R signaling pathway, and found that one of the agonists exhibited biased agonism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jyothi Thittamranahalli Kariyappa, Simone Zanoni, Andre Bongers, Lydia Tong, Ken W. S. Ashwell
Summary: The study mapped brain regions and connections in a diprotodontid marsupial using high-field microstructural MRI. They identified new cortical connectivity patterns and emphasized the importance of these findings for understanding mammalian brain evolution.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Veronica Casado-Anguera, Estefania Moreno, Marta Sanchez-Soto, Ning Sheng Cai, Jordi Bonaventura, Patricia Homar-Ruano, Marcelo Rubinstein, Antoni Cortes, Enric Canela, Sergi Ferre, Vicent Casado
Summary: This study suggests that the formation of αR-2A-D4R heteromers may play a crucial role in catecholaminergic signaling in the brain cortex, serving as potential targets for ADHD pharmacotherapy. The negative crosstalk within the heteromer is lost in cortex from hD(4.7)R knock-in mice and in cells expressing the D4.7R polymorphic variant, indicating a unique role of this specific variant. The lack of efficacy of D4R ligands to promote G protein activation and signaling only within the αR-2A-D4.7R heteromer highlights the complex interaction between these receptors.
PHARMACOLOGICAL RESEARCH
(2021)
Editorial Material
Clinical Neurology
Thiviya Selvanathan, Mireille Guillot, Helen M. Branson, Vann Chau, Edmond N. Kelly, Steven P. Miller
Summary: Malformations of cortical development (MCD) are a rare group of disorders caused by genetic, metabolic, infectious, or vascular factors that disrupt the development of the cerebral cortex. They are typically detected with brain MRI when symptomatic, but recent advances allow for detection during fetal or neonatal periods. This study presents neuroimaging findings and neurodevelopmental outcomes of a very preterm infant with incidentally detected MCD on neonatal research brain MRI.
Article
Clinical Neurology
Iris J. Broce, Eduardo Caverzasi, Simone Sacco, Ryan Michael Nillo, Matteo Paoletti, Rahul S. Desikan, Michael Geschwind, Leo P. Sugrue
Summary: This study investigated the relationship between regional PRNP expression in healthy brain tissue and diffusion abnormalities and atrophy patterns in patients with sporadic Creutzfeldt-Jakob disease (sCJD). PRNP microarray data from healthy brains and T1-weighted and diffusion-weighted MRIs from sCJD patients and healthy controls were used to examine correlations between PRNP expression, diffusion measures, cortical morphology, and local gyrification index. The results showed that regional patterns of PRNP expression were associated with diffusion abnormalities and atrophy in sCJD, with the local gyrification index exhibiting the strongest correlation. These findings suggest that the genetic and molecular environment influence the vulnerability of different brain regions to misfolding of the prion protein, which is reflected in imaging findings in sCJD. Larger studies are needed to validate these regional imaging patterns as reliable markers for distinct disease subtypes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Gianpaolo Antonio Basile, Salvatore Bertino, Alessia Bramanti, Rosella Ciurleo, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
Summary: Novel imaging techniques have been developed for precise delineation of thalamic nuclei, allowing for reliable identification of up to 13 distinct nuclei bilaterally. These high-resolution imaging methods have potential implications for studying thalamic connectivity, basic research, and presurgical planning.
Article
Multidisciplinary Sciences
Ju Young Lee, Andreas F. Mack, Thomas Shiozawa, Renata Longo, Giuliana Tromba, Klaus Scheffler, Gisela E. Hagberg
Summary: In this study, a new method using edge-based segmentation was employed to extract the 3D microvasculature from unstained human brain tissue. The results revealed distinctive types of blood vessels in the superior colliculi and provided measurements of vessel diameter, length, and volume fraction. This method opens up new possibilities for investigating vascular research of the central nervous system.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Preeti Kumari Chaudhary, Soochong Kim
Summary: GPCRs play a crucial role in cancer progression, but the specific mechanisms of their involvement are still unclear. Studies have revealed the multifaceted impact of GPCRs on cancer development and the signaling pathways involved.
Article
Clinical Neurology
Oya Kuseyri Huebschmann, Natalia Alexandra Julia-Palacios, Mireia Olivella, Philipp Guder, Dimitrios I. Zafeiriou, Gabriella Horvath, Jan Kulhanek, Toni S. Pearson, Alice Kuster, Elisenda Cortes-Saladelafont, Salvador Ibanez, Maria Concepcion Garcia-Jimenez, Tomas Honzik, Rene Santer, Kathrin Jeltsch, Sven F. Garbade, Georg F. Hoffmann, Thomas Opladen, Angeles Garcia-Cazorla
Summary: This study investigates the Glycine encephalopathy and proposes a severity prediction model based on clinical, biochemical, and genetic parameters, expanding the phenotypic spectrum of attenuated NKH.
ANNALS OF NEUROLOGY
(2022)
Review
Cell Biology
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A. Rockman
Summary: This review explores the signaling pathways, dynamic structures, and physiological relevance of the three most important GPCR signaling effectors in the cardiovascular system: heterotrimeric G proteins, GPCR kinases (GRKs), and 8-arrestins. It summarizes their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. The application of new technologies has contributed to an increasing understanding of GPCR structure and downstream effectors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Zhengguang Guo, Chen Shao, Yang Zhang, Wenying Qiu, Wenting Li, Weimin Zhu, Qian Yang, Yin Huang, Lili Pan, Yuepan Dong, Haidan Sun, Xiaoping Xiao, Wei Sun, Chao Ma, Liwei Zhang
Summary: This study provides a global multiregional proteomic map of the human cerebral cortex by analyzing 29 Brodmann areas. The findings identify cluster-specific and BA-specific signature proteins that are closely associated with specialized functions and disease vulnerability.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga R. Krishnan, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk
Summary: The study found that indole sulfate, a metabolite of gut microbiota, was closely associated with anxiety symptoms but not related to post-treatment outcomes. This suggests that cognitive behavioral therapy and antidepressant medications relieve anxiety through mechanisms unrelated to modulation of gut-derived indoles.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Suzanne N. Haber, Hesheng Liu, Jakob Seidlitz, Ed Bullmore
Summary: This review discusses the fundamental importance of prefrontal cortical connectivity to information processing and disorders of cognition, emotion, and behavior. It introduces the methods used to study monosynaptic prefrontal cortical connections in non-human primates and MRI-derived measurements of network organization in humans. The review also demonstrates how tract-tracing studies can inform the composition of prefrontal cortex nodes and hubs.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Sergei Chavez-Abiega, Max L. B. Groenloh, Theodorus W. J. Gadella, Frank J. Bruggeman, Joachim Goedhart
Summary: This study reveals substantial cell-to-cell heterogeneity in kinase activity driven by GPCRs through imaging and analysis strategy.
JOURNAL OF CELL SCIENCE
(2022)
Article
Neurosciences
Cuong Pham, Daniela Herrera Moro, Christine Mouffle, Steve Didienne, Regine Hepp, Frank W. Pfrieger, Jean-Marie Mangin, Pascal Legendre, Claire Martin, Serge Luquet, Bruno Cauli, Dongdong Li
Article
Multidisciplinary Sciences
Shinobu Nomura, Ludovic Tricoire, Ivan Cohen, Bernd Kuhn, Bertrand Lambolez, Regine Hepp
Article
Cell Biology
Oriane Pourchet, Marie-Pierre Morel, Quentin Welniarz, Nadege Sarrazin, Fabio Marti, Nicolas Heck, Cecile Gallea, Mohamed Doulazmi, Sergi Roig Puiggros, Juan Antonio Moreno-Bravo, Marie Vidailhet, Alain Trembleau, Philippe Faure, Alain Chedotal, Emmanuel Roze, Isabelle Dusart
Summary: Depletion of floor plate Netrin-1 in the brainstem disrupts CST midline crossing and leads to abnormal motor control, particularly causing symmetric movements. This study reveals the role of Netrin-1 in CST development and provides a mouse model replicating the characteristics of human congenital mirror movements.
Article
Neurosciences
Cuong Pham, Karine Herault, Martin Oheim, Steeve Maldera, Vincent Vialou, Bruno Cauli, Dongdong Li
Summary: This study investigated astrocytic responses to the neurotoxic A beta fragment present in Alzheimer's disease patients through fluorescence imaging of signaling pathways. The results showed that A beta 25-35 induced different Ca2+ responses in astrocytes in different states, accompanied by a multiphasic release of signaling molecules.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Neurosciences
Gabrielle Devienne, Sandrine Picaud, Ivan Cohen, Juliette Piquet, Ludovic Tricoire, Damien Testa, Ariel A. Di Nardo, Jean Rossier, Bruno Cauli, Bertrand Lambolez
Summary: Inhibition of parvalbumin-expressing (PV) interneurons in adult mice can induce perineuronal net (PNN) regression, while activation of these neurons does not reduce PNN density. The density of PNN in the adult cortex is regulated by local changes in network activity, which can be triggered through modulation of PV interneurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Claire Nguyen, Sarah Mondoloni, Tinaig Le Borgne, Ines Centeno, Maxime Come, Joachim Jehl, Clement Solie, Lauren M. Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sebastien Valverde, Steve Didienne, Bernadette Hannesse, Jean-Francois Fiancette, Stephanie Pons, Uwe Maskos, Veronique Deroche-Gamonet, Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faure
Summary: Nicotine affects dopamine neurons in the ventral tegmental area, eliciting opposite functional responses in different populations of neurons projecting to different brain regions, leading to anxiety-like behavior.
Article
Multidisciplinary Sciences
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Durante, Damien Lemoine, Raphael Britto, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jeremie Naude, Philippe Faure
Summary: Chronic nicotine exposure affects decision-making processes, including exploratory behaviors, by increasing the tonic activity of VTA dopaminergic neurons and reducing exploration in mice. Long-term nicotine exposure alters brain circuits and leads to significant changes in decision-making strategies, impacting behaviors related and unrelated to drug seeking and consumption. The study also shows that optogenetically stimulating mice mimics the effects of chronic nicotine on dopamine neuron activity, highlighting a potential mechanism by which nicotine influences decision-making processes.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, Helene Geoffroy, Regine Hepp, Jeremie Naude, Benjamin Le Gac, Richard Egger, Bertrand Lambolez, Dongdong Li, Jean Rossier, Jochen F. Staiger, Hiromi Imamura, Susumu Seino, Jochen Roeper, Bruno Cauli
Summary: Research shows that in active neurons, lactate is preferred over glucose as an energy substrate, and lactate metabolism shapes neuronal activity in the neocortex through K-ATP channels. This highlights the importance of metabolic crosstalk between neurons and astrocytes for brain function.
Review
Behavioral Sciences
Philippe Faure, Sophie L. Fayad, Clement Solie, Lauren M. Reynolds
Summary: Individuals vary in their traits and preferences, which impact their interactions, survival prospects, and susceptibility to diseases. Although there is evidence for these correlations, the underlying neurophysiological mechanisms and their relation to vulnerability to diseases are not well understood. Social ties are believed to play a significant role in modulating personality traits and psychiatric vulnerability, but most neuroscience studies are conducted on socially deprived rodents. Rodent micro-society paradigms are therefore crucial for understanding how social life contributes to diversity through shaping individual traits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biology
Matthieu Lepine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Veronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivien
Summary: The study reveals that tPA released from cortical FS-PV interneurons in the central nervous system can reduce the density of PNNs by degrading CSPGs. This finding provides valuable insights into the control of brain plasticity.
Article
Biology
Sophie L. Fayad, Guillaume Ourties, Benjamin Le Gac, Baptiste Jouffre, Sylvain Lamoine, Antoine Fruquiere, Sophie Laffray, Laila Gasmi, Bruno Cauli, Christophe Mallet, Emmanuel Bourinet, Thomas Bessaih, Regis C. Lambert, Nathalie Leresche, Gary L. Westbrook
Summary: Cav3.2 channels expressed in GABAergic neurons in the anterior pretectum contribute to high-frequency bursting activity and play a role in neuropathic pain.
Article
Biology
Damien Lemoine, Sarah Mondoloni, Jerome Tange, Bertrand Lambolez, Philippe Faure, Antoine Taly, Ludovic Tricoire, Alexandre Mourot
Article
Biology
Marwen Belkaid, Elise Bousseyrol, Romain Durand-de Cuttoli, Malou Dongelmans, Etienne K. Durante, Tarek Ahmed Yahia, Steve Didienne, Bernadette Hanesse, Maxime Come, Alex Mourot, Jeremie Naude, Olivier Sigaud, Philippe Faure
COMMUNICATIONS BIOLOGY
(2020)