Is the inflammasome a potential therapeutic target in renal disease?

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

Regulation of interleukin 1α secretion by inflammasomes: Table 1

(2012) Amir S Yazdi et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with end-stage renal disease admitted to the intensive care unit: systematic review

(2012) N. Arulkumaran et al.   BRITISH JOURNAL OF ANAESTHESIA

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis

(2012) Simona Deplano et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Beneficial Effect of Interleukin 1 Inhibition with Anakinra in Adult-onset Still's Disease. An Open, Randomized, Multicenter Study

(2012) D. NORDSTROM et al.   JOURNAL OF RHEUMATOLOGY

Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells

(2012) Iman Jalilian et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

High White Blood Cell Count and Low Estimated Glomerular Filtration Rate Are Independently Associated With Serum Level of Monocyte Chemoattractant Protein-1 in a General Population

(2011) Ako Fukami et al.   CLINICAL CARDIOLOGY

P2X7 receptor positively regulates MyD88-dependent NF-κB activation

(2011) Yanhui Liu et al.   CYTOKINE

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage

(2011) Syed Raza Ali et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

(2011) T. Bergsbaken et al.   JOURNAL OF IMMUNOLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Emerging Roles for the Interferon-Inducible p200-Family Proteins in Sex Bias in Systemic Lupus Erythematosus

(2011) Divaker Choubey et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interleukin-18 Stimulates a Positive Feedback Loop During Renal Obstruction via Interleukin-18 Receptor

(2011) Brian A. VanderBrink et al.   JOURNAL OF UROLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Protective Effects of Exogenous Interleukin 18–Binding Protein in a Rat Model of Acute Renal Ischemia-Reperfusion Injury

(2011) Jun Wang et al.   SHOCK

Renal cytokine profile in an endotoxemic porcine model

(2010) A. GRANFELDT et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications

(2010) Takayuki Fujita et al.   ACTA DIABETOLOGICA

Passive immunization against tumour necrosis factor-alpha (TNF-α) and IL-lβ protects from LPS enhancing glomerular injury in nephrotoxic nephritis in rats

(2010) A. M. KARKAR et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Elevated Urinary IL-18 Levels at the Time of ICU Admission Predict Adverse Clinical Outcomes

(2010) E. D. Siew et al.   Clinical Journal of the American Society of Nephrology

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-1β induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of ERK, JNK, AP-1, and NF-κB

(2010) Chuen-Mao Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice

(2010) R. Imamura et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression

(2010) Guangwen Ren et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Mediates Hyperoxia-Induced Alveolar Cell Permeability

(2010) N. Kolliputi et al.   JOURNAL OF IMMUNOLOGY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

(2010) Nicole B Bryan et al.   Journal of Inflammation-London

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells

(2009) K Wareham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Vascular Calcification: The Killer of Patients with Chronic Kidney Disease

(2009) M. Mizobuchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis

(2009) S. R.J. Taylor et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-18 neutralization ameliorates obstruction-induced epithelial–mesenchymal transition and renal fibrosis

(2009) Ahmad H. Bani-Hani et al.   KIDNEY INTERNATIONAL

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor and macrophage function

(2009) Mark D. Wewers et al.   Purinergic Signalling

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 trap) in patients with familial cold autoinflammatory syndrome

(2008) Raphaela Goldbach-Mansky et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Deletion of IL-18 receptor ameliorates renal injury in bovine serum albumin-induced glomerulonephritis

(2008) Masafumi Sugiyama et al.   CLINICAL IMMUNOLOGY

IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

(2008) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-18 is involved in vascular injury in end-stage renal disease patients

(2008) T. Porazko et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Administration of interleukin-1 receptor antagonist ameliorates renal ischemia-reperfusion injury

(2008) Krisztina Rusai et al.   TRANSPLANT INTERNATIONAL

The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

(2008) Rieke Alten et al.   ARTHRITIS RESEARCH & THERAPY