Review
Chemistry, Multidisciplinary
Mojtaba Kamankesh, Abbas Yadegar, Antoni Llopis-Lorente, Chenguang Liu, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Ali Shokrgozar, Mohammad Reza Zali, Amir Hossein Miri, Mazda Rad-Malekshahi, Michael R. Hamblin, Matthias G. Wacker
Summary: This article summarizes recent advances in nanostructured drug delivery systems for treating Helicobacter pylori infection. It proposes a drug release paradigm to prevent antibiotic resistance and establishes an IVIVC model to connect drug release profile with reduction in bacterial colony counts. It discusses local delivery systems including mucoadhesive, mucopenetrating, and cytoadhesive nanobiomaterials, as well as engineered delivery platforms such as polymer-coated nanoemulsions and polymer-coated nanoliposomes. These bioinspired platforms can prevent antibiotic resistance development, specifically kill H. pylori, and have minimal negative effects on the host gastrointestinal microbiota. The essential checkpoints for confirming the potential effectiveness of anti-H. pylori nanosystems are also discussed.
Review
Microbiology
Jessyca Aparecida Paes Dutra, Suzana Goncalves Carvalho, Aline Soares de Oliveira, Jessica Raquel Borges Monteiro, Jessica Rodrigues Pereira de Oliveira Borlot, Marcela Tavares Luiz, Tais Maria Bauab, Rodrigo Rezende Kitagawa, Marlus Chorilli
Summary: Helicobacter pylori infection is a major cause of gastric issues in half the world's population, posing challenges in clinical treatment. Nanoparticles and microparticles offer promising strategies for improving drug delivery and selectivity in treating H. pylori infection.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Qingtao Song, Xiaoyong Ding, Yilin Liu, Wenjuan Liu, Jing Li, Bohan Wang, Zhongwei Gu
Summary: We designed an active drug combination therapy and responsive drug release for Helicobacter pylori using self-propelled micromotors. These micromotors can penetrate the mucus layer, deliver amoxicillin and clarithromycin, and release them in a pH-responsive manner. The micromotors showed enhanced retention and distribution capability, and significantly improved antimicrobial efficiency compared to single-drug loaded micromotors. The optimized dosage ratio of amoxicillin and clarithromycin on the micromotors was determined to be 2:1.
APPLIED MATERIALS TODAY
(2023)
Article
Polymer Science
Ghufran Ullah, Asif Nawaz, Muhammad Shahid Latif, Kifayat Ullah Shah, Saeed Ahmad, Fatima Javed, Mulham Alfatama, Siti Aisyah Abd Ghafar, Vuanghao Lim
Summary: Bilayer/multilayer tablets are commonly used to tailor drug release, and this research aimed to formulate a novel gastro-retentive tablet to eliminate H. pylori in the gastrointestinal tract. Bilayer tablets were prepared using the direct compression technique, and the controlled-release bilayer tablets were prepared using hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M). The study concluded that the combination of sodium alginate, chitosan, and HPMC polymers resulted in a gastro-retentive and controlled-release drug delivery system.
Article
Chemistry, Multidisciplinary
Tyler P. P. Graf, Sherry Yue Qiu, Dhruv Varshney, Mei-Li Laracuente, Erin M. M. Euliano, Pujita Munnangi, Brett H. H. Pogostin, Tsvetelina Baryakova, Arnav Garyali, Kevin J. J. McHugh
Summary: PULSED is a novel drug delivery system that provides a sequence of doses in a single injection, improving patient adherence and therapeutic efficacy. It utilizes high-resolution 3D printing and soft lithography to form biodegradable polymeric microstructures with an open cavity, which are filled with drug and sealed using contactless heating. The system exhibits versatility and compatibility with various drugs, with the potential to simplify drug formulations at a low cost and scale effectively.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Wan-Hua Lin, Sadhan C. Jana
Summary: This research investigates the porous structures of cellulose aerogel monoliths and microparticles, and evaluates the potential of cellulose aerogel microparticles in drug delivery. The aerogels exhibit high porosity, significant mesopores, and a high specific surface area. The porous architecture of the microparticles leads to a slower drug release compared to direct loading into aqueous medium.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Polymer Science
Iolanda De Marco
Summary: Zein is a biodegradable and biocompatible polymer, widely used in pharmaceutical and biomedical fields. As a hydrophobic biopolymer, it is used for controlled and targeted delivery of active principles. This review examines the production techniques, optimization parameters, advantages, disadvantages, and applications of zein-based microparticles and nanoparticles.
Article
Chemistry, Physical
Chundong Xue, Yirong Huang, Xu Zheng, Guoqing Hu
Summary: This study investigates the diffusion behavior of nanoparticles in porous hydrogels through experiments and simulations. The results reveal that nanoparticles can escape from pores through connective pathways and exhibit a non-Gaussian displacement probability distribution. The anomalous diffusion can be fully described by combining the hopping mechanism and the hydrodynamic effect.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Materials Science, Biomaterials
Yuan Qin, Yeh-Hsing Lao, Haixia Wang, Jiabin Zhang, Ke Yi, Zhuanggui Chen, Jing Han, Wantong Song, Yu Tao, Mingqiang Li
Summary: H. pylori infection is the main cause of most digestive diseases, and traditional oral medication is limited in its efficacy, while nanomedicine offers efficient and effective targeted drug delivery solutions.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Chemical
Raul Edison Luna Lazo, Bruna de Paula Oliveira, Alexandre de Fatima Cobre, Luana Mota Ferreira, Karina Bettega Felipe, Paulo Renato de Oliveira, Fabio Seigi Murakami
Summary: This study successfully developed SDF-loaded porous micro particles for pulmonary administration, which exhibited high encapsulation efficiency and sustained release, and showed noncytotoxicity at the cellular level.
Article
Engineering, Biomedical
Wei Duan, Yao Jin, Yaoxuan Cui, Fengna Xi, Xingyue Liu, Fangjie Wo, Jianmin Wu
Summary: This study demonstrates a co-delivery platform based on biodegradable and therapeutic porous silicon microparticles for synergistic promotion of angiogenesis. The co-delivery of Si ions and VEGF shows a synergistic effect in enhancing blood vessel formation in vitro and in vivo.
Article
Chemistry, Physical
Chetan Sharma, Nalin H. Maniya, Meghal A. Desai, Sanjaykumar R. Patel
Summary: Porous silicon microparticles were prepared by electrochemical etching process for the study of telmisartan loading and release kinetics. Telmisartan loaded porous silicon microparticles showed higher drug loading compared to thermally oxidized porous silicon, with controlled release observed in the former. Telmisartan-loaded porous silicon microparticles can be a viable option for controlled drug delivery of poorly water-soluble active pharmaceutical ingredients.
Article
Multidisciplinary Sciences
Weronika Gonciarz, Magdalena Chmiela, Bartlomiej Kost, Ewelina Piatczak, Marek Brzezinski
Summary: Encapsulation of Salvia cadmica extracts in stereocomplexed microparticles made of biodegradable polymers can enhance the immune response towards Helicobacter pylori. The extracts improve the phagocytic activity of guinea pig macrophages and neutralize H. pylori-induced production of TNF-alpha and IL-10. Further in vivo studies in guinea pigs infected with H. pylori are recommended to confirm the immunomodulatory effects of the encapsulated extracts.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jason Tan, Yunhui Fang, Chuan Yang, Joyce Tay, Nathanael Tan, Nithiyaa Bala Krishnan, Boon Lin Chua, Yanli Zhao, Yunbo Chen, James L. Hedrick, Yi Yan Yang
Summary: This study presents the synthesis of new polymers capable of selectively killing Helicobacter pylori in the acidic environment of the stomach, while remaining non-toxic to commensal bacteria in the gut. The polymers demonstrated strong antibacterial activity against H. pylori in simulated gastric conditions, and their assembly behavior was influenced by the pH of the environment. The study provides valuable insights into the design and application of antimicrobial polymers.
Article
Chemistry, Multidisciplinary
Yanqi Qiao, Mengfan Han, Hongli Fu, Yaying Xu, Yueping Bai, Shuo Wang, Jie Yu, Changjun Men, Yongmei Yin, Xiujie Zhao, Rimo Xi, Meng Meng
Summary: This study engineered a phototherapeutic nanomedicine that can penetrate gastric mucus and target MDR H. pylori infection. In in vivo experiments, the nanomedicine showed impressive eradication of H. pylori.
Article
Materials Science, Biomaterials
Zhongjun Cheng, Rui Qing, Shilei Hao, Yi Ding, Haimeng Yin, GuoDong Zha, Xiaoliang Chen, Jingou Ji, Bochu Wang
Summary: An oral keratin hydrogel has been developed to accelerate ulcer healing without the need for endoscopic guidance, providing a promising biomaterial-based approach for treating gastrointestinal ulcers.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yuhua Gong, Peng Ren, Jia Deng, Zongkun Hou, Tingwang Guo, Shilei Hao, Bochu Wang
Summary: The study found that mass effect after intracerebral hemorrhage (ICH) accelerates erythrolysis and brain damage, which can be alleviated by trehalose therapy.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Neurosciences
Yu-hua Gong, Shi-lei Hao, Bo-chu Wang
Summary: Intracerebral hemorrhage (ICH) is a leading cause of death and long-term disability worldwide. Research has shown that mesenchymal stem cell (MSC) therapy can improve neuronal defects caused by ICH, but key issues regarding the survival, differentiation, and safety of grafted MSCs still need to be resolved for clinical translation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Yumei Wang, Yingqian Xu, Zhi Zhang, Ye He, Zongkun Hou, Zhibin Zhao, Jia Deng, Rui Qing, Bochu Wang, Shilei Hao
Summary: Keratins are promising candidates for hemostatic agents, but their development has been hindered by the complexity of their structure. Utilizing a recombinant synthesis approach, different types of keratins can be expressed and studied for the design of high-performance keratin hemostatic agents. Research findings suggest that mutating keratins with high α-helical content can significantly enhance their hemostatic efficiency.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Immunology
Changfa Sun, Bochu Wang, Shilei Hao
Summary: The adenosine-A2AR pathway plays a crucial role in regulating immune responses and tumor progression. Blocking this pathway can inhibit tumor growth and has potential synergistic effects with CAR T cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Rui Qing, Shilei Hao, Eva Smorodina, David Jin, Arthur Zalevsky, Shuguang Zhang
Summary: Water solubility and structural stability are important aspects of protein design, relying on accurate placement of amino acids and molecular interactions. Designer proteins have applications in computational design models and biomedical and nanotechnological applications. Advances in protein science, computing power, algorithms, and characterization techniques provide tools for solubility design. This review summarizes progress in protein design for solubility and stability.
Article
Environmental Sciences
Zongkun Hou, Run Meng, Ganghua Chen, Tangmin Lai, Rui Qing, Shilei Hao, Jia Deng, Bochu Wang
Summary: This study investigates the accumulation, toxicity, and mechanism of polystyrene nanoplastics (PS-NPs) in human intestinal cells. The results show that PS-NPs can accumulate in different types of intestinal cells, leading to cell apoptosis and inflammatory response. The inhibition of clathrin-mediated endocytosis effectively reduces the accumulation of PS-NPs in secretive cells. This research not only reveals the potential uptake and toxicity of PS-NPs in human intestines, but also proposes a therapeutic approach to alleviate their toxicity through endocytosis inhibition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Dongliang Zhai, Yumei Wang, Songke Yu, Jiren Zhou, Jia Song, Shilei Hao, Xiaoliang Chen
Summary: The clinical diagnosis and treatment of malignant bone tumors remain challenging due to their high incidence and difficulty. Targeted therapies, especially radiopharmaceuticals, have shown promising results in treating bone tumors. In this study, P-32-labeled hydroxyapatite (HA) was prepared using chemical synthesis and physical adsorption. The chemical synthesis method exhibited higher radiolabeling yield and stability compared to physical adsorption. The results also demonstrated the effectiveness of P-32-Hap in treating bone tumors, suggesting that P-32-Hap combined with DOX may be an effective strategy for bone metastasis treatments.
Review
Environmental Sciences
Minghui Li, Zongkun Hou, Run Meng, Shilei Hao, Bochu Wang
Summary: With the global spread of disposable face masks (DFMs), the release of microplastics and nanoplastics has caused concerns about their potential impact on human health. However, little attention has been paid to the release process of these particles from masks in the natural environment. This review discusses the abiotic and biotic degradation of DFMs and explores the potential toxicity of mask-derived microplastics and nanoplastics, including gastrointestinal, pulmonary, neurological, hepatic, reproductive, and transgenerational toxicity.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Liling Chen, Run Meng, Rui Qing, Wenfeng Li, Ziwei Wang, Yao Hou, Jia Deng, Wei Pu, Zibin Gao, Bochu Wang, Shilei Hao
Summary: We have successfully developed robust keratin hydrogels based on mechanism study through recombinant proteins, which outperform combinations of native proteins in mechanical properties and in biomedical applications.
Article
Chemistry, Multidisciplinary
Wenjie Zhong, Dongjie Shi, Junjie Zhou, Yaying Yang, Bochu Wang, Xiaochuan Sun, Qian Shu, Wenfeng Li, Yongzhi Xia, Lei Ao, KangLin Xiong, Shilei Hao, Haijian Xia
Summary: This study explores the anti-inflammatory activity of 17 types of human hair keratins and finds that keratin 33A and 35 have superior anti-inflammatory effects. The in vivo experiments using a rat spinal cord injury model confirm the outstanding performance of recombinant keratin 33A nanofiber in promoting nerve regeneration and improving locomotor function recovery.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Run Meng, Shilei Hao, Changfa Sun, Zongkun Hou, Yao Hou, Lili Wang, Peiying Deng, Jia Deng, Yaying Yang, Haijian Xia, Bochu Wang, Rui Qing, Shuguang Zhang
Summary: In this study, a protein design approach called reverse-QTY (rQTY) code was used to convert hydrophilic alpha-helices in human serum albumin (HSA) to hydrophobic alpha-helices, resulting in the formation of well-ordered nanoparticles with high biological activity. The designed HSArQTY variants exhibited superior biological activities, including drug encapsulation, receptor-mediated cellular transport, tumor cell targeting, and antitumor efficiency, compared to denatured HSA nanoparticles. HSArQTY nanoparticles provided better tumor targeting and antitumor therapeutic effects compared to albumin nanoparticles fabricated by antisolvent precipitation method. The rQTY code is considered as a robust platform for specific hydrophobic modification of functional hydrophilic proteins with clear-defined binding interfaces.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Multidisciplinary
Haojie Zhang, Yinping Pan, Yao Hou, Minghui Li, Jia Deng, Bochu Wang, Shilei Hao
Summary: Transdermal drug delivery systems based on physical principles have provided a stable, efficient, and safe strategy for disease therapy. Intelligent design and concepts have enabled real-time monitoring and precise drug release. The combination with pharmaceutical dosage forms can achieve better transdermal effects and facilitate the development of smart medical devices.
Article
Chemistry, Multidisciplinary
Jie Chen, Yumei Wang, Jia Deng, Rui Qing, Yaxi Yang, Xiaoliang Chen, Zibin Gao, Bochu Wang, Shilei Hao
Summary: Water-soluble keratins were synthesized using the QTY code, leading to a 200-fold increase in water solubility without apparent structural changes. Homotypic self-assembly was observed for the first time in aqueous environment after QTY modification. The QTY variant keratins showed superior hemostatic and wound healing activities compared to native recombinant keratins.
Article
Engineering, Biomedical
Changfa Sun, Wenjie Liu, Lili Wang, Run Meng, Jia Deng, Rui Qing, Bochu Wang, Shilei Hao
Summary: Infectious wounds pose significant challenges in clinical practice and developing new antibiotics has become increasingly difficult. In this study, a K31-PGLa hydrogel was designed and synthesized, which demonstrated synergistic effects with commercial antibiotics against drug-resistant bacteria by down-regulating efflux pump synthesis genes. Furthermore, the photopolymerized K31-PGLa/PEGDA hydrogels effectively inhibited the growth of drug-resistant bacteria and promoted skin wound closure in mice.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
