Article
Engineering, Biomedical
Neda Aslankoohi, Shigang Lin, Kibret Mequanint
Summary: This study introduced dexamethasone-loaded organic-inorganic hybrid microparticles as a standalone osteogenic differentiation inducer. The microparticles supported cell adhesion and proliferation in culture, and induced osteogenic differentiation of stem cells without the need for any additional differentiation media supplements. Therefore, the fluorescent PEA-BG hybrid microparticles show promise as a standalone biomaterial for bone regeneration.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Inseob Choi, Nan Li, Qixin Zhong
Summary: This study demonstrated the potential of using porous vegetable microparticles as natural matrices to load lipophilic bioactive compounds in functional foods. The FDPMs showed high absorption capacity and retention rate for RSV, as well as a protective effect under UV irradiation and high bioaccessibility during digestion. Additionally, the increased reducing power of RSV in FDPMs was supported by their amorphous state.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Wan-Hua Lin, Sadhan C. Jana
Summary: This research investigates the porous structures of cellulose aerogel monoliths and microparticles, and evaluates the potential of cellulose aerogel microparticles in drug delivery. The aerogels exhibit high porosity, significant mesopores, and a high specific surface area. The porous architecture of the microparticles leads to a slower drug release compared to direct loading into aqueous medium.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Physical
Chetan Sharma, Nalin H. Maniya, Meghal A. Desai, Sanjaykumar R. Patel
Summary: Porous silicon microparticles were prepared by electrochemical etching process for the study of telmisartan loading and release kinetics. Telmisartan loaded porous silicon microparticles showed higher drug loading compared to thermally oxidized porous silicon, with controlled release observed in the former. Telmisartan-loaded porous silicon microparticles can be a viable option for controlled drug delivery of poorly water-soluble active pharmaceutical ingredients.
Article
Orthopedics
Junlei Li, Fang Cao, Bin Wu, Jiahui Yang, Wenwu Xu, Weidan Wang, Xiaowei Wei, Ge Liu, Dewei Zhao
Summary: This study successfully immobilized VEGF on the surface of degradable magnesium through polydopamine, giving it angiogenic bioactivity. This method has the potential to promote bone tissue regeneration and play a significant role in the clinical treatment of large bone defects.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Biophysics
Bo Wang, Guanghua Lu, Kaihang Song, Aopan Chen, Hu Xing, Jiezhou Wu, Qi Sun, Gen Li, Ming Cai
Summary: In this study, dual bioactive agent-loaded electrospinning nanofibers were successfully prepared for the treatment of infectious wounds. The addition of zinc oxide nanoparticles and vascular endothelial growth factors to the fibers resulted in membranes with suitable physicochemical properties and promising biological activity, as demonstrated through in vitro and in vivo experiments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Matthias Schumacher, Pamela Habibovic, Sabine van Rijt
Summary: The slow and disorganized formation of a functional vascular network in large bone defect regeneration can cause delayed healing or implant failure. This study introduces a promising strategy by immobilizing the pro-angiogenic growth factor VEGF on nanosized bioactive glass particles using a binding peptide, which can induce angiogenesis and overcome the problem of insufficient neovascularization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Food Science & Technology
Marta Gallardo-Fernandez, Ana B. Cerezo, Ruth Hornedo-Ortega, Ana M. Troncoso, M. Carmen Garcia-Parrilla
Summary: This study revealed the molecular mechanism underlying the inhibition of VEGF signaling by hydroxytyrosol metabolites and indolic compounds, and established a relationship between their structure and bioactivity. The compounds exhibited anti-angiogenic effects by regulating signaling pathways such as PLC gamma 1 and eNOS.
Article
Engineering, Environmental
Qimeng Ran, Zilin Fan, Xinkai Guo, Xiulan Li, Keyu Yi, Xiaobo Liu, Kun Jia
Summary: Functional porous microparticles with a fluorescent ability for simultaneous adsorption removal and online monitoring of hexavalent chromium were synthesized and demonstrated. The microparticles exhibited competitive adsorption and fluorescent detection of Cr (VI) due to their porous structure, abundant surface binding sites, and green fluorescence emission that can be selectively quenched by Cr (VI). The optimized microparticles showed a maximum Cr(VI) adsorption capacity of 553.92 mg.g(-1) and a limit of detection for Cr (VI) down to 1.92 nM.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Thi Hien Nguyen, Thuy Chinh Nguyen, Thi Minh Tu Nguyen, Dinh Hoa Hoang, Do Mai Trang Tran, Dinh Thang Tran, Phuong Thai Hoang, Van Tan Le, Thi Kim Ngan Tran, Hoang Thai
Summary: The study developed microparticles loaded with alpha-mangostin extracted from Vietnamese mangosteen skin using carrageenan and chitosan. The microparticles exhibited improved release ability of alpha-mangostin into solutions, maintained its bioactivities, reduced vero cell toxicity, and showed antibacterial and antioxidant activities. The combination of chitosan and carrageenan in the microparticles enhanced the controlled release of alpha-mangostin.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Wozniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee
Summary: The study revealed that crocetin was more effective than crocin in inhibiting angiogenesis by regulating the VEGF/VEGFR2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Biomaterials
Anqi Lin, Shengyang Liu, Lan Xiao, Yingying Fu, Changsheng Liu, Yulin Li
Summary: This study developed size-controllable microspheres with an open-porous structure, which were treated with alkalization to obtain a highly open pore structure and a large specific surface area. The microspheres showed potential as an ideal cell carrier to increase cell density and bioactivity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Sumit Kumar Pramanik, Amitva Das
Summary: Recently, fluorescent probes have shown significant advancements in responding to subtle changes in subcellular microenvironments and are associated with various biological disorders. The design of fluorescent probes should be tailored for organelle specificity and reporting changes in intracellular biochemicals/microenvironmental factors.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marin-Aurel Trofin, Stefania Racovita, Silvia Vasiliu, Ana-Lavinia Vasiliu, Marcela Mihai
Summary: Crosslinked porous microparticles have gained significant attention as drug delivery systems due to their unique properties. In this study, novel porous zwitterionic microparticles with antifouling, antimicrobial and hydration properties were successfully prepared. The microparticles showed high drug loading and release capacities, and demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: This study successfully generated 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents, showing high efficiency in combating bacteria. The release mechanism was found to be Fickian diffusion.
Article
Biochemical Research Methods
Congying Wen, Mengmeng Li, Wangbo Li, Zizhou Li, Wei Duan, Yulong Li, Jie Zhou, Xiyou Li, Jingbin Zeng
JOURNAL OF CHROMATOGRAPHY A
(2017)
Article
Chemistry, Multidisciplinary
Jingbin Zeng, Min Li, Ao Liu, Fan Feng, Teng Zeng, Wei Duan, Mengmeng Li, Mingfu Gong, Cong-Ying Wen, Yadong Yin
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Chemistry, Analytical
Jingbin Zeng, Yulong Li, Xiaofu Zheng, Zizhou Li, Teng Zeng, Wei Duan, Qing Li, Xiao Shang, Bin Dong
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Yaoxuan Cui, Wei Duan, Yao Jin, Fangjie Wo, Fengna Xi, Jianmin Wu
Article
Nanoscience & Nanotechnology
Yao Jin, Yudong Yang, Wei Duan, Xuetong Qu, Jianmin Wu
Summary: The study developed a dual synergistic antibacterial platform based on AgNPs and AMP, showing excellent antibacterial effect with on-demand release ability. PSiMPs as a carrier efficiently loaded AgNPs and AMP, releasing Ag+ and AMP under bacterial infection conditions, promoting wound healing by synergistic antibacterial efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Yaoxuan Cui, Wei Duan, Yao Jin, Fangjie Wo, Fengna Xi, Jianmin Wu
Summary: In this study, a stimuli-responsive smart dressing for diabetic wound theranostics was developed using graphene quantum dots-decorated luminescent porous silicon. The nanomaterial exhibited enhanced peptide drug loading capacity and efficient fluorescence resonance energy transfer (FRET) effect for effective diabetic wound treatment. The smart dressing showed stimuli-responsive drug release behavior and significantly enhanced the healing of diabetic wounds in both in vitro and in vivo studies.
ACTA BIOMATERIALIA
(2021)
Article
Biophysics
Wei Duan, Zhiwei Qiu, Shoufu Cao, Qi Guo, Jiankun Huang, Jinyan Xing, Xiaoqing Lu, Jingbin Zeng
Summary: In this study, an ultrasensitive colorimetric method for biothiols detection was developed based on the design of a Janus Pd-Fe3O4 nanozyme using density functional theory. The nanozyme showed enhanced peroxidase-like activity and sensitivity to biothiols due to its unique structure. The method demonstrated a detection limit of 3.1 nM and successfully differentiated biothiols levels in normal and cancer cells, showing great potential for biological and clinical analysis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Zhiwei Qiu, Wei Duan, Shoufu Cao, Teng Zeng, Tianyu Zhao, Jiankun Huang, Xiaoqing Lu, Jingbin Zeng
Summary: In this paper, a highly specific colorimetric method for fluoride (F-) using AgPt-Fe3O4 nanozyme was proposed. The method has 100% aqueous compatibility and a low detection limit. The color changes are induced by the oxidation of SiO2 shell, and the method shows high selectivity towards F- over other common anions, making it suitable for analyzing complex sewage samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xingyue Liu, Zhao Chen, Tao Wang, Xinrong Jiang, Xuetong Qu, Wei Duan, Fengna Xi, Zhengfu He, Jianmin Wu
Summary: The tissue imprinting technology using 2D nanoflakes-capped silicon nanowires allows for convenient and authentic revelation of molecular distribution on tissue samples, which is crucial for accurate cancer diagnosis.
Article
Nanoscience & Nanotechnology
Wei Duan, Xingyue Liu, Jingwen Zhao, Yongke Zheng, Jianmin Wu
Summary: This study demonstrates that surface modification of porous silicon with polydopamine can endow the classical drug carrier with a significant photothermal effect for advanced antibacterial therapy and wound disinfection. The carrier can release antibacterial substances and drugs under multiple stimuli, exhibiting amplified, broad-spectrum, and synergistic antibacterial effect. In vivo experiments show efficient bacterial ablation and wound healing with negligible side effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Wei Duan, Jinling Wang, Xiaomeng Peng, Shoufu Cao, Jingjing Shang, Zhiwei Qiu, Xiaoqing Lu, Jingbin Zeng
Summary: We have designed a hydrophilic AgPt-Fe3O4 nanozyme with a unique heterodimeric nanostructure for CO sensing. The nanozyme is highly susceptible to CO poisoning due to the adequate exposure of active metallic sites and efficient interfacial synergy. We have developed a colorimetric strategy for CO detection with a low detection limit of 5.6 ppb.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Wei Duan, Jingwen Zhao, Xingyue Liu, Yongke Zheng, Jianmin Wu
Summary: This study proposes a thermal signal-based method for monitoring reactive oxygen species (ROS) levels by detecting the change in photothermal signal of near-infrared (NIR)-active dye (IR820) released from a porous silicon (PSi)-based carrier. Using a portable smartphone equipped with a thermal camera, ROS levels at wounds can be conveniently and non-invasively monitored to indicate exacerbation or healing conditions. Moreover, the NIR-triggered smart delivery platform also triggers photothermal and photodynamic therapy to inhibit bacterial growth and promote cell migration and angiogenesis. With the synergistic advantages of ROS-responsive property, prohealing ability, anti-infection effect, and excellent biosafety, this new theranostic platform achieves convenient diagnosis and effective treatment in diabetic wound infection models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Yao Jin, Wei Duan, Fangjie Wo, Jianmin Wu
ACS APPLIED NANO MATERIALS
(2019)
Article
Chemistry, Analytical
Wei Duan, Ao Liu, Qing Li, Zhiwei Li, Cong-ying Wen, Zhixiong Cai, Shiming Tang, Xiyou Li, Jingbin Zeng
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.