Article
Chemistry, Analytical
Dalton L. Glasco, Nguyen H. B. Ho, Art Matthew Mamaril, Jeffrey G. Bell
Summary: This technical note introduces a method for fabricating ion-selective membranes using 3D printing technology for potentiometric sensing, demonstrating high stability and reproducibility in different electrode configurations. The versatile approach allows for the seamless translation of these membranes into reliable sensors for various applications, highlighting the advantages of mass production and reduced time and cost associated with sensor fabrication.
ANALYTICAL CHEMISTRY
(2021)
Article
Ophthalmology
Nobuo Takeda, Masamichi Fukuda, Hiroshi Sasaki, Kazuhisa Sugiyama
Summary: The study showed that preservative-free ophthalmic solutions such as dorzolamide/timolol without BAK did not significantly affect corneal electrical resistance, while solutions with low concentrations of BAK had a significant impact. Fluorescein staining was unable to detect corneal epithelium changes that were detected by CRDs.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Murat Dogru, Takashi Kojima, Kazunari Higa, Ayako Igarashi, Haruka Kudo, Wolfgang G. K. Mueller-Lierheim, Kazuo Tsubota, Kazuno Negishi
Summary: The study found that a novel high molecular weight hyaluronic acid and Latanoprost eye drop had similar intraocular pressure-lowering effects compared to commercially available Latanoprost eye drops, while also reducing ocular surface inflammation. This suggests that the new eye drop formulation provides comparable IOP lowering effects to the market product, while also reducing ocular surface alterations and inflammatory reactions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Edina Szabo, Evelin Patko, Alexandra Vaczy, Dorottya Molitor, Adrienne Csutak, Gabor Toth, Dora Reglodi, Tamas Atlasz
Summary: This study investigated the effects of PACAP1-38 eye drops on a glaucoma model, showing that it can lower intraocular pressure, slow down retinal degeneration, and restore functionality. This indicates the potential for future therapeutic administration of PACAP1-38 in glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Omer Ersin Muz, Kenan Dagdelen, Tuncay Pirdal, Mete Guler
Summary: Travatan (R) and Xalatan (R) have similar effects on IOP levels and ocular surface parameters in patients with POAG and OHT, and no further worsening was detected after 1 year.
INTERNATIONAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Sukhmandeep Kaur, Phulen Sarma, Hardeep Kaur, Manisha Prajapat, Nishant Shekhar, Jaimini Bhattacharyya, Harpinder Kaur, Subodh Kumar, Bikash Medhi, Jagat Ram, Dipankar Das, Pramod Avti, Ajay Prakash, Rahul Singh, Anusuya Bhattacharyya
Summary: This study found that cysteamine performed better than placebo and control in terms of treatment response and improvement, and was more effective in reducing corneal cystine density compared to other formulations.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nam-Hui Yim, Eunhee Park, Won-Kyung Cho, Yeoun-Hee Kim, Jin Yeul Ma
Summary: This study investigated the effects of two extracts from Acer palmatum leaves on dry eye. The results showed that the extracts increased tear production, reduced inflammation and cell death, and alleviated dry eye symptoms. Topical administration of KIOM-2015EE demonstrated better therapeutic effects compared to oral administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Gali Brand, Idan Hecht, Zvia Burgansky-Eliash, Liron Naftali Ben Haim, Duncan Leadbetter, Oriel Spierer, Asaf Achiron
Summary: The study showed that Autodrop and Opticare aids can assist patients in accurately instilling eye drops and prevent bottle tip contamination. The use of aids also resulted in fewer instances of bottle tip contamination and less leakage of eye drops compared to using the conventional bottle alone.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Anne Hedengran, Miriam Kolko
Summary: Glaucoma is a major cause of irreversible blindness, and reducing intraocular pressure (IOP) with eye drops is the most common treatment approach. However, the many side effects of eye drops often lead to reduced patient adherence. This review discusses the various molecular components of IOP-lowering eye drops and highlights important considerations when prescribing topical glaucoma treatment.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Ophthalmology
David Wirta, Ranjan Malhotra, James Peace, Bridgitte Shen Lee, Brittany Mitchell, Kenneth Sall, Matthew McMenemy
Summary: This study evaluated the noninferiority of latanoprost without benzalkonium chloride (BAK) compared to latanoprost with BAK in lowering intraocular pressure (IOP). The results showed that latanoprost without BAK did not meet two out of three criteria for noninferiority, but had a similar safety profile to latanoprost with BAK.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Yanlin Zhong, Xie Fang, Xuemei Wang, Yu-An Lin, Huping Wu, Cheng Li
Summary: This study found that the bacterial communities on the ocular surface changed significantly after the use of sodium hyaluronate eye drops. Regardless of the presence of preservatives, eye drops have an impact on the bacterial communities on the ocular surface.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Koichi Baba, Noriyasu Hashida, Motokazu Tujikawa, Andrew J. Quantock, Kohji Nishida
Summary: This study describes the formulation of fluormetholone nanocrystal eye drops and compares their characteristics with fluormetholone microcrystal formulation. The nanocrystal formulation showed higher penetration and longer duration of action compared to the microcrystal formulation. Additionally, the nanocrystals were found to be stable when stored at 10 degrees Celsius for up to 6 months.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Ophthalmology
Giuseppe Suanno, Philippe Fonteyne, Giulio Ferrari
Summary: This study used a mouse model of dry eye disease induced by BAK to examine its stability and the presence of neurosensory abnormalities. The results showed that BAK treatment significantly increased corneal fluorescein staining, ocular pain, leukocyte infiltration, and reduced corneal sensitivity and tear secretion. Moreover, discontinuation of BAK treatment improved corneal epithelial damage. Therefore, BAK is an important factor contributing to DED.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Myungsik Nam, Sun Woong Kim
Summary: Corneal epithelial thickness (CET) was found to be smaller in patients with glaucoma receiving topical medications compared to controls. Among various factors influencing CET, the use of beta-blockers, prostaglandin, and frequency of BAK-containing instillations were significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Malin Glindvad Ahlstrom, Lone Skov, Steffen Heegaard, Claus Zachariae, Lene Heise Garvey, Jeanne Duus Johansen
Summary: A retrospective study in a Danish tertiary dermatology department found that allergic contact dermatitis (ACD) in the eye region caused by topical eye medications is difficult to diagnose and may be overlooked. The study identified phenylephrine, timolol, and ketotifen as the main culprits of contact allergy to topical eye allergens/medications. Patients often had previous diagnoses of cataract or glaucoma and reported multiple previous reactions, with symptoms including edema, erythema, and dermatitis in the eye region.
CONTACT DERMATITIS
(2023)