Comparison of BAK-preserved latanoprost and polyquad- preserved travoprost on ocular surface parameters in patients with glaucoma and ocular hypertension

Background To compare the effect of two different prostaglandin analogues (Travatan (R) vs. Xalatan (R)) on ocular surface parameters. Methods This study includes 44 eyes of 44 patients with newly diagnosed primary open-angle glaucoma (POAG) or ocular hypertension (OHT). Patients were randomly divided into two groups and treated with either benzalkonium chloride (BAK)-preserved latanoprost and polyquad-preserved travoprost. Changes in intraocular pressure (TOP) levels and ocular surface parameters including ocular surface disease index (OSDI) questionnaire, tear breakup time (TBUT), ocular surface staining scores, and Schirmer test scores of patients were performed at baseline, 1, 3, 6, and 12 months of treatment and compared. Results The age, sex ratio, visual acuity, central corneal thickness, and cup/disc ratio were similar between the groups. A decrease in IOP levels (23.3 +/- 2.5 to 15.5 +/- 2.3), TBUT (5.5 +/- 2.3 to 4.1 +/- 1.7 s), Schirmer test values (11.3 +/- 5.9 to 8.6 +/- 4.7 s), and a worsening in OSDI scores (44.6 +/- 15.2 to 55.1 +/- 13.1) and staining scores (1.7 +/- 1.6 to 2.3 +/- 1.8) were observed in all patients in the first month of treatment (p < 0.05, for all). No further worsening was detected during the 1-year follow-up. There was no difference between the groups in terms of alterations in IOP levels and ocular surface parameters. Conclusion Travatan (R) and Xalatan (R) have a similar effect on IOP levels and ocular surface parameters in patients with POAG and OHT.

Automated summary

Travatan (R) and Xalatan (R) have similar effects on IOP levels and ocular surface parameters in patients with POAG and OHT, and no further worsening was detected after 1 year.