Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Nirali Shukla, Ankit Naik, Kamlesh Moryani, Molisha Soni, Jigna Shah, Heena Dave
Summary: This review focuses on the signaling pathways and biological activities of the TGF-beta family in breast cancer pathogenesis and highlights its potential as a biomarker and drug target. It is beneficial for early detection, disease monitoring, and treatment selection in breast cancer.
Article
Cardiac & Cardiovascular Systems
Mikita Karalko, Marek Pojar, Lenka Zaloudkova, Vaclav Stejskal, Salifu Timbilla, Pavla Brizova, Jan Vojacek
Summary: The concentration of TGF-beta 1 is not suitable as a specific marker for aortic dilatation, but it is sensitive to aortic valvulopathy-aortopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Menglin Zou, Jingfeng Zou, Xingxing Hu, Weishuai Zheng, Mingyang Zhang, Zhenshun Cheng
Summary: The elevated expression of LTBP2 plays a critical role in pulmonary fibrosis (PF) and contributes to fibroblast-to-myofibroblast differentiation. Silencing LTBP2 protects against PF and suppresses the differentiation of fibroblasts into myofibroblasts. Meanwhile, overexpression of LTBP2 induces this differentiation process even in the absence of TGF beta 1, indicating a potential therapeutic target for PF.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, General & Internal
Jianmeng Zhao, Xiaokang Liu, Ke Cong, Jinzhe Chang, Hongqing Shan, Yuenan Zheng
Summary: The analysis suggests that LTBP2 is significantly associated with the survival of cancer patients. High LTBP2 expression is an independent prognostic factor indicating poor survival.
Review
Gastroenterology & Hepatology
Aswathy R. Devan, Keechilat Pavithran, Bhagyalakshmi Nair, Maneesha Murali, Lekshmi R. Nath
Summary: Transforming growth factor-beta 1 (TGF-β1) plays a dual role as a tumor suppressor and promoter in cancer, particularly in hepatocellular carcinoma (HCC). Elevated levels of TGF-β1 in HCC contribute to poor prognosis and immunosuppression in the tumor microenvironment. TGF-β1 is an important diagnostic, prognostic, and therapeutic target for HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Chunlai Shi, Xuan Li, Fei Hong, Xueyan Wang, Tingting Jiang, Bingbing Sun, Shuang Li
Summary: Cardiac fibrosis is a crucial process in the development of heart failure, and LTBP2 may accelerate cardiac fibroblast apoptosis by regulating the expression and activity of caspase-3. LTBP2 could be a potential therapeutic target for treating patients with cardiac fibrosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zixuan Liu, Mingming Chen, Yini Sun, Xu Li, Liu Cao, Xiaochun Ma
Summary: Heparin-binding protein (HBP), secreted by neutrophils, plays a role in the pathophysiology of sepsis. Our studies showed that HBP binds to transforming growth factor-beta receptor type 2 (TGF-beta-R2) and triggers acute lung injury and vascular leakage through the TGF-beta/SMAD2/3 signaling pathway. The role of HBP and TGF-beta-R2 in HBP-related acute lung injury at the blood-gas barrier was also defined.
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
T. Xing, Z. R. Zhao, X. Zhao, X. L. Xu, L. Zhang, F. Gao
Summary: Wooden breast myopathy in broiler chickens induces severe fibrosis in the pectoralis major muscle by enhancing extracellular matrix deposition, collagen cross-linking, and dysregulating TGF-beta signaling and the MMP and TIMP system.
Article
Oncology
Shiori Tokizaki, Katarzyna A. Podyma-Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, Kohei Miyazono, Mikako Shirouzu, Tetsuro Watabe
Summary: The signaling pathway of transforming growth factor-beta plays an important role in tumor cell proliferation and angiogenesis in the tumor microenvironment. Fc chimeric TGF-beta receptor can inhibit these signaling pathways and is a promising tool for targeting the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Multidisciplinary Sciences
Zelin Duan, Xuezhen Lin, Lixia Wang, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao, Jianchuan Wang, Zhe Zhang
Summary: The authors elucidated the underlying mechanisms of specific presentation of L-TGF-beta 1 on the surface of myeloid lineage cells designated by LRRC33, and its activation by integrin alpha V beta 8.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.