Energy metabolism and rheumatic diseases: from cell to organism

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

(2012) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

(2011) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Exercise-induced myokines and their role in chronic diseases

(2011) Bente K. Pedersen   BRAIN BEHAVIOR AND IMMUNITY

When T Cells Run Out of Breath: The HIF-1α Story

(2011) Katherine Nutsch et al.   CELL

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation

(2011) Ruben Ghillebert et al.   FEBS Journal

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3

(2011) Gillian M. Tannahill et al.   FEBS LETTERS

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Interaction between oxidative stress and chemokines: Possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis

(2011) Dilip Shah et al.   IMMUNOBIOLOGY

Glycolysis and rheumatoid arthritis

(2011) Xiaotian CHANG et al.   International Journal of Rheumatic Diseases

Circadian rhythms, sleep, and metabolism

(2011) Wenyu Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Differential Modulation of ATP-Induced P2X7-Associated Permeabilities to Cations and Anions of Macrophages by Infection with Leishmania amazonensis

(2011) Camila Marques-da-Silva et al.   PLoS One

IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates

(2011) Ellen M. Moran et al.   PLoS One

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Intracellular metabolic pathways control immune tolerance

(2011) Claudio Procaccini et al.   TRENDS IN IMMUNOLOGY

Neuroendokrinimmunologie

(2011) R.H. Straub   ZEITSCHRIFT FUR RHEUMATOLOGIE

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis

(2010) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases

(2010) Rainer H. Straub   BRAIN BEHAVIOR AND IMMUNITY

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

(2010) R. Dziurla et al.   IMMUNOLOGY LETTERS

Macrophage Migration Inhibitory Factor Counterregulates Dexamethasone-Mediated Suppression of Hypoxia-Inducible Factor-1  Function and Differentially Influences Human CD4+ T Cell Proliferation under Hypoxia

(2010) T. Gaber et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Review: Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases

(2010) R. H. Straub et al.   JOURNAL OF INTERNAL MEDICINE

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study

(2009) Tien-I Karleen Su et al.   ARTHRITIS AND RHEUMATISM

Antigen processing and presentation: TAPping into ABC transporters

(2009) Erik Procko et al.   CURRENT OPINION IN IMMUNOLOGY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Prolongs Monocyte/Macrophage Survival and Enhanced Glycolysis Is Associated with Their Maturation under Aerobic Conditions

(2009) J. Roiniotis et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

(2009) Christian Beyer et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

(2008) M. V. Sitkovsky et al.   CLINICAL CANCER RESEARCH

Human CD4+ T cells maintain specific functions even under conditions of extremely restricted ATP production

(2008) Robert Tripmacher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial dysfunction and HIF1  stabilization in inflammation

(2008) A. Garedew et al.   JOURNAL OF CELL SCIENCE

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL