Article
Chemistry, Analytical
Omair Adil, Seth B. Eddington, Keith T. Gagnon, Mohtashim H. Shamsi
Summary: Overgrowth of short tandem repeat sequences in genes can cause neurodegenerative disorders. These repeat sequences are ideal targets for label-free electrochemical detection, but their secondary structures and sporadic repeats can complicate detection. By analyzing different nucleic acid microprobe backbones, the study found that the lock-nucleic acid (LNA) microprobe can specifically detect tandem repeats and perform better with the presence of Mg2+. The LNA-based platform shows potential for the development of a reliable biosensor for genetic neurodegenerative disorders.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Ruiyun Zhou, Chen Wang, Yuxin Huang, Kang Huang, Yingli Wang, Wendao Xu, Lijuan Xie, Yibin Ying
Summary: This study investigates the integration of graphene with THz metasurface into a microfluidic cell for sensitive biosensing in liquid environment, demonstrating high sensitivity in detecting DNA sequences of Escherichia coli O157:H7. The results suggest the potential of the proposed graphene-metasurface microfluidic biosensor for label-free biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yao Chen, Yu Zhong, Ji-Xing Ye, Yun Lei, Ai-Lin Liu
Summary: In this study, a sensitive and selective electrochemical DNA biosensor was developed for the determination of a osteosarcoma-related survivin gene. The proposed strategy used a simple and low-cost working electrode, with no need for other substances for electrode or DNA functionalization. The mode of interaction between celestine blue (CB) and DNA was studied, and it was found that the possible mode was intercalation with a binding number of 2 and a binding constant beta of 10(12.87). The label-free electrochemical DNA biosensor showed a good linear relationship towards the target gene and had a low detection limit of 0.046 nM.
Article
Chemistry, Analytical
Kenta Nakama, Mohammed Sedki, Ashok Mulchandani
Summary: A novel chemiresistor biosensor using M13 phage-modified reduced graphene oxide was developed for detecting E. coli. The sensor showed a linear and specific response towards E. coli with high selectivity, indicating potential in detecting coliforms.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biophysics
Jose M. R. Flauzino, Emily P. Nguyen, Qiuyue Yang, Giulio Rosati, David Panacek, Ana G. Brito-Madurro, Joao M. Madurro, Aristides Bakandritsos, Michal Otyepka, Arben Merkoci
Summary: This study presents a label-free impedimetric genosensor for the sensitive detection of pork residues in meat, utilizing the biosensing capabilities of graphene acid. The sensor can detect pork residues in beef in less than 45 minutes, with a detection limit of 9%.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Jilai Jia, Xiaoping Du, Xuqin Lv, Fang Xie, Jiaojiao Zhou, Jie Cai
Summary: A DNA-mediated growth strategy was developed in this study for the synthesis of platinum nanoparticles (PtNPs) on the surface of graphene oxide (GO). The resulting GO-DNA-PtNPs exhibited excellent peroxidase-mimicking activity, and the activity could be inhibited by Hg(2+) due to the specific trapping of Hg2+ by thymine bases (T-Hg2+-T) and in situ reduction of Hg2+ by PtNPs on the GO surface. The sensor showed good linear range (from 1 pM to 1 μM) and a detection limit of 2.2 pM for Hg2+ analysis, demonstrating excellent analytical performance in complex lake waters.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Narges Asefifeyzabadi, Grace Durocher, Kizito-Tshitoko Tshilenge, Tanimul Alam, Lisa M. Ellerby, Mohtashim H. Shamsi
Summary: We have developed a PNA microprobe sensing platform that utilizes electrochemical impedance spectroscopy to detect trinucleotide repeat mutation. The platform successfully identified Huntington's disease-associated CAG repeats in cell-derived total RNA with a signal-to-noise ratio of 1:3. This sensitive, label-free, and PCR-free detection strategy shows potential for the development of biosensing platforms for various repeat expansion disorders.
Article
Chemistry, Analytical
Chen-chen Li, Yue-hong Dong, Xiaoran Zou, Xiliang Luo, Dazhong Shen, Juan Hu, Chun-yang Zhang
Summary: A label-free and template-free chemiluminescent biosensor, termed hmC-GLIB-IAS, has been developed for sensitive detection of 5hmC in genomic DNA. This method shows advantages of bisulfite-free, improved sensitivity, and genome-wide analysis of 5hmC at constant reaction temperature. It can detect 5hmC with a high reproducibility and accuracy without isotope-labeled substrates or specific antibodies.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Elena Alina Chiticaru, Celina Maria Damian, Luisa Pilan, Mariana Ionita
Summary: This study proposes a simple, label-free, and cost-effective DNA detection platform using screen-printed carbon electrodes modified with reduced graphene oxide and gold nanoparticles. The preparation process and electrochemical properties of the modified electrodes were characterized and confirmed. The introduction of gold nanoparticles onto the electrode surface enhanced surface conductivity and sensitivity in detection.
Article
Chemistry, Analytical
Yonghao Jia, Jianyu Wang, Shari Yosinski, Yuehang Xu, Mark A. Reed
Summary: In this paper, a potentiometric method using silicon nanowire biosensors is used to monitor the concentration of glutamine in the bioprocess. A more convenient hydrolyzation reaction is used, and the Al2O3 sensing layer and the Sigmoidal function are employed to achieve consistent and fast monitoring results.
Article
Physics, Condensed Matter
Khuraijam Nelson Singh, Pranab Kishore Dutta
Summary: The study presents a novel biosensor based on FET with channel grading and underlap region for label-free biosensing application. The proposed biosensor not only exhibits high sensitivity, but also improves circuit performance.
SUPERLATTICES AND MICROSTRUCTURES
(2021)
Article
Biochemistry & Molecular Biology
Li Li, Zhengbo Chen
Summary: In this study, a high specificity, flexibility, and simplicity aptasensor strategy was designed using a triblock DNA probe. It was found that the polyA fragment could assemble on the gold electrode surface via polyA instead of traditional Au-S bonds, leading to improved hybridization stability. The electrochemical aptasensor showed good repeatability, stability, and specificity.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Physical
Yang Sun, Shicai Xu, Tiying Zhu, Jiajun Lu, Shuo Chen, Maomao Liu, Guangcan Wang, Baoyuan Man, Huamin Li, Cheng Yang
Summary: In this study, a photocurrent-modulated FET sensor for DNA hybridization detection was proposed, achieving a detection limit down to attomolar concentrations. The sensor significantly enhances the response signal compared to traditional FET sensors, opening new avenues for further development in biosensing applications.
Article
Chemistry, Analytical
Yuetong Yang, Derong Kong, Yungen Wu, Yiheng Chen, Changhao Dai, Chang Chen, Junhong Zhao, Shi Luo, Wentao Liu, Yunqi Liu, Dacheng Wei
Summary: A graphene field-effect transistor (GFET) biosensor based on a tetrahedral DNA nanostructure (TDN)-assisted catalytic hairpin assembly (CHA) reaction (TCHA) has been developed, allowing sensitive and specific detection of miRNA-21. The TDN structures in the biosensing interface facilitate the CHA reaction and prevent unwanted entanglements, aggregation, and adsorption of probes on the graphene channel. The biosensor exhibits ultra-sensitive detection of miRNA-21, with a detection limit of 5.67 x 10(-19) M, three orders of magnitude lower than that achieved by graphene transistors with single-stranded DNA probe functionalization of the channel. Furthermore, the biosensor demonstrates excellent performance in terms of selectivity, stability, and reproducibility, showing promising potential in bioanalysis and clinical diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yuetong Yang, Derong Kong, Yungen Wu, Yiheng Chen, Changhao Dai, Chang Chen, Junhong Zhao, Shi Luo, Wentao Liu, Yunqi Liu, Dacheng Wei
Summary: Graphene field-effect transistors (GFETs) offer simple and label-free diagnostics for sensitive and specific detection of microRNAs (miRNAs). Researchers have developed a GFET biosensor based on tetrahedral DNA nanostructures (TDN) that facilitates catalytic hairpin assembly (CHA) reaction for ultrasensitive detection of miRNA-21. The biosensor exhibits excellent analytical performance and has been successfully applied in complex serum environments and cell lysates, showing promising potential in bioanalysis and clinical diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Taghi Ahmadi, Morteza Bodaghzadeh, Seyed Saeid Rahimian Koloor, Michal Petru
Summary: The research focused on sensing nitrate ions in the environment using carbon-based materials, specifically with carbon nanoparticles formed from high-density polyethylene polymer. Through the pulsed arc discharge method, a metal-nanoparticle-metal contact was fabricated between electrodes to recognize nitrate ions. The graphene nano-strand demonstrated the ability to distinguish various nitrate compounds in different densities, with simulation and comparison studies showing realistic agreement between proposed structure and measured results.
Article
Engineering, Electrical & Electronic
V Khaki, Mohammad Taghi Ahmadi, M. Hassanzadazar, Truong Khang Nguyen
Summary: The study investigates the electronic behavior of various silicon-doped carbon nanoscrolls and reveals that small-diameter armchair Si-doped carbon nanoscrolls exhibit metallic behavior, while those with a diameter that is a multiple of 3 show semiconductor behavior. Additionally, large-diameter armchair Si-doped carbon nanoscrolls demonstrate semiconducting behavior with a small band gap between the valence and conduction bands.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Mohammad Taghi Ahmadi, Banafsheh Alizadeh Arashloo, Truong Khang Nguyen
Summary: Carbon-based materials like graphene and its derivatives play important roles in nano-technological applications, with Memristor receiving attention as a nonvolatile memory solution. This study explores a Memristor model based on graphene oxide, demonstrating the formation of conductive paths by increasing voltage and achieving resistance switching.
AIN SHAMS ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Vahideh Khademhosseini, Daryoosh Dideban, Mohammad Taghi Ahmadi, Hadi Heidari
Summary: The single electron transistor (SET) is a nanoscale switching device that operates based on the tunneling of single electrons. In this study, multiple quantum dot islands such as graphene nanoscroll-carbon nanotubes (GNS-CNT) and graphene nanoscroll-fullerene (GNS-C-60) are used in SET devices. The impacts of important parameters such as temperature and applied gate voltage on the current of these SETs are investigated, along with the effects of various structural factors on the current. The results show that the GNS-CNT SET has a lower Coulomb blockade range and a higher current than the GNS-C-60 SET.
Article
Physics, Multidisciplinary
Mohammad Taghi Ahmadi, Esmaeil Rahmatpour, Meisam Rahmani
Summary: This study investigated the relaxation effect of overlap energy variation on the pi and pi* bands location in alpha-graphyne, a promising material in technological applications. The control of overlap energy by external parameters was discussed, as well as the Eigen values of band energy and the intertwined effect of single and double bonds energies as an overlap energy parameter. The study also compared tight-binding model and density functional theory method, supporting the accuracy of the presented model and showing new hopes for the use of alpha-graphyne in nanoelectronics and optoelectronics applications.
Article
Engineering, Electrical & Electronic
Sonay Neshani, Mohammad Taghi Ahmadi, Meisam Rahmani
Summary: This research studies the bubble-wrap carbon nanostructure, which is a hybrid structure of fullerene with a graphene sheet. By enlarging the bubble fullerenes and increasing the hopping energies between carbon atoms, the metallic structure is transformed into a semi-metal one. These findings are significant for various applications of nanotechnology such as nanoelectronics.
JOURNAL OF COMPUTATIONAL ELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Ramin Ahmadi, Mohammad Taghi Ahmadi, Hatef Sadeghi
Summary: This study investigates the geometrical effects of low dimensional graphene-based materials (GBM) on thermoelectric properties, and finds that the number of twists has a more significant impact compared to fullerene diameter and number of dimer lines.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Ramin Ahmadi, Mohammad Taghi Ahmadi
Summary: This paper investigates the application of graphene nanoribbon-twisted graphene (GNR-TWG) junction in Schottky transistor and studies its electrical characteristics through calculations and experiments. The results show that increasing the number of twists and width of GNR leads to an increase in drain current and threshold voltage.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Behrouz Rouzkhash, Alireza Salehi, Mohammad Taghi Ahmadi
Summary: The use of gamma-graphyne-1 nanotubes (GyNTs) in tunneling field effect transistors (TFETs) improves their performance by suppressing ambipolarity and enhancing the subthreshold swing (SS). The analysis of the structural, electronic, and thermoelectric properties of GyNTs reveals their potential for use in TFETs. The experimental results demonstrate the excellent performance of GyNT-TFETs, making them suitable candidates for next-generation nanoelectronic devices.
JOURNAL OF COMPUTATIONAL ELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Meisam Rahmani, Hassan GhafooriFard, Mohammad Taghi Ahmadi, Esmaeil Rahmatpour
Summary: This paper analytically investigates the momentum relaxation mean free time and path, as well as the ionization coefficient of trilayer graphene nanoribbon in nanoscale field-effect transistors (FETs). The models are derived based on the energy band structure and calculations of effective mass, carrier velocity, and scattering rate. The effects of interlayer potential energies, temperature, and potential difference of layers on the modeled parameters are also considered. The obtained results and findings are in agreement with published data and demonstrate promising performance for transistor applications.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Parasto Ahani, Mohammad Taghi Ahmadi, Amir Musa Abazari, Meisam Rahmani
Summary: This paper investigates the band structure and effective parameters of Boron Nitro silicon (Si2BN) and finds that the distance between conduction and valence bands and the band gap can be modified by controlling the hopping energy and lattice constant. This research has important implications for applications in nanoelectronics.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Mohammad Taghi Ahmadi, Roghayeh Gozali Balkanloo, Meisam Rahmani, Amir Musa Abazari
Summary: Graphene is a semiconductor with zero band-gap, which is not ideal for electronic devices. By changing the structure of graphene, a new sample called penta graphene with a non-zero band-gap can be obtained. Penta graphene is stronger than graphene and has lower electron transfer ability. The research shows that the band gap of penta graphene can be adjusted by changing the bond energy, resulting in an overlap between the conduction and valance bands.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Mohamad Taghi Ahmadi, Mahsa Hesami, Meisam Rahmani
Summary: Electromagnetic waves play a crucial role in our lives, but they also pose a threat to human health and the functioning of electrical devices. This study explores the design and development of frequency-selective surfaces using metamaterials as absorbers, and finds that structures based on hexagonal loops can effectively filter specific frequency bands.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
