KSHV LANA—The Master Regulator of KSHV Latency

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency

(2014) R. Sun et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Induce Chromosomal Instability through Targeted Degradation of the Mitotic Checkpoint Kinase Bub1

(2014) Z. Sun et al.   JOURNAL OF VIROLOGY

Inhibition of KAP1 Enhances Hypoxia-Induced Kaposi's Sarcoma-Associated Herpesvirus Reactivation through RBP-J 

(2014) L. Zhang et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Contributes to Viral Latent Replication by Activating Phosphorylation of Survivin

(2014) J. Lu et al.   JOURNAL OF VIROLOGY

Activation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by Inhibitors of Class III Histone Deacetylases: Identification of Sirtuin 1 as a Regulator of the KSHV Life Cycle

(2014) Q. Li et al.   JOURNAL OF VIROLOGY

Site-Specific Association with Host and Viral Chromatin by Kaposi's Sarcoma-Associated Herpesvirus LANA and Its Reversal during Lytic Reactivation

(2014) A. Mercier et al.   JOURNAL OF VIROLOGY

Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence

(2014) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-Encoded MicroRNAs Facilitate Gammaherpesvirus Latency and Pathogenesis In Vivo

(2014) E. R. Feldman et al.   mBio

LANA Binds to Multiple Active Viral and Cellular Promoters and Associates with the H3K4Methyltransferase hSET1 Complex

(2014) Jianhong Hu et al.   PLoS Pathogens

Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis

(2014) Deguang Liang et al.   PLoS Pathogens

KSHV 2.0: A Comprehensive Annotation of the Kaposi's Sarcoma-Associated Herpesvirus Genome Using Next-Generation Sequencing Reveals Novel Genomic and Functional Features

(2014) Carolina Arias et al.   PLoS Pathogens

Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells

(2013) Jun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Redefining KSHV Latency

(2013) Ohad Yogev et al.   Cell Host & Microbe

A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity

(2013) Henry H Chang et al.   Cell Host & Microbe

H2AX Phosphorylation Is Important for LANA-Mediated Kaposi's Sarcoma-Associated Herpesvirus Episome Persistence

(2013) H. C. Jha et al.   JOURNAL OF VIROLOGY

Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat Stability

(2013) J. Dheekollu et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency-Associated Nuclear Antigen Regulates the KSHV Epigenome by Association with the Histone Demethylase KDM3A

(2013) K. Y. Kim et al.   JOURNAL OF VIROLOGY

Keeping it quiet: chromatin control of gammaherpesvirus latency

(2013) Paul M. Lieberman   NATURE REVIEWS MICROBIOLOGY

Comprehensive Analysis of LANA Interacting Proteins Essential for Viral Genome Tethering and Persistence

(2013) Subhash C. Verma et al.   PLoS One

The Chromatin Landscape of Kaposi’s Sarcoma-Associated Herpesvirus

(2013) Zsolt Toth et al.   Viruses-Basel

KSHV MicroRNAs Mediate Cellular Transformation and Tumorigenesis by Redundantly Targeting Cell Growth and Survival Pathways

(2013) Rosalie Moody et al.   PLoS Pathogens

Biphasic Euchromatin-to-Heterochromatin Transition on the KSHV Genome Following De Novo Infection

(2013) Zsolt Toth et al.   PLoS Pathogens

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency

(2013) Qiliang Cai et al.   PLoS Pathogens

Cancer Angiogenesis Induced by Kaposi Sarcoma-Associated Herpesvirus Is Mediated by EZH2

(2012) M. He et al.   CANCER RESEARCH

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats

(2012) Pravinkumar Purushothaman et al.   JOURNAL OF VIROLOGY

Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA

(2012) F. Lu et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Multifunctional Angiogenin To Utilize Its Antiapoptotic Functions

(2012) N. Paudel et al.   JOURNAL OF VIROLOGY

Snapshots: Chromatin control of viral infection

(2012) David M. Knipe et al.   VIROLOGY

Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation

(2012) Qiliang Cai et al.   PLoS Pathogens

The RBP-Jκ Binding Sites within the RTA Promoter Regulate KSHV Latent Infection and Cell Proliferation

(2012) Jie Lu et al.   PLoS Pathogens

KSHV PAN RNA Associates with Demethylases UTX and JMJD3 to Activate Lytic Replication through a Physical Interaction with the Virus Genome

(2012) Cyprian C. Rossetto et al.   PLoS Pathogens

Kaposi’s Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency

(2012) Eriko Ohsaki et al.   Frontiers in Microbiology

KSHV Rta Promoter Specification and Viral Reactivation

(2012) Jonathan Guito et al.   Frontiers in Microbiology

Post-Translational Modifications of Kaposi’s Sarcoma-Associated Herpesvirus Regulatory Proteins – SUMO and KSHV

(2012) Mel Campbell et al.   Frontiers in Microbiology

Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome

(2012) Mark N. Polizzotto et al.   Frontiers in Microbiology

Protein Arginine Methyltransferase 1-directed Methylation of Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen

(2011) Mel Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Single RBP-J  Site within the LANA Promoter Is Crucial for Establishing Kaposi's Sarcoma-Associated Herpesvirus Latency during Primary Infection

(2011) J. Lu et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen and Angiogenin Interact with Common Host Proteins, Including Annexin A2, Which Is Essential for Survival of Latently Infected Cells

(2011) N. Paudel et al.   JOURNAL OF VIROLOGY

In vitro centromere and kinetochore assembly on defined chromatin templates

(2011) Annika Guse et al.   NATURE

Kaposi's Sarcoma Herpesvirus microRNAs Target Caspase 3 and Regulate Apoptosis

(2011) Guillaume Suffert et al.   PLoS Pathogens

Murine Gamma-herpesvirus Immortalization of Fetal Liver-Derived B Cells Requires both the Viral Cyclin D Homolog and Latency-Associated Nuclear Antigen

(2011) Xiaozhen Liang et al.   PLoS Pathogens

Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent Replication

(2011) Subhash C. Verma et al.   PLoS Pathogens

Reactive Oxygen Species Hydrogen Peroxide Mediates Kaposi's Sarcoma-Associated Herpesvirus Reactivation from Latency

(2011) Fengchun Ye et al.   PLoS Pathogens

Pathology of Kaposi’s sarcoma-associated herpesvirus infection

(2011) Hitomi Fukumoto   Frontiers in Microbiology

DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi’s sarcoma-associated herpesvirus latent replication

(2010) Seho Cha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses

(2010) Samuel H. Speck et al.   Cell Host & Microbe

An Interleukin‐6–Related Systemic Inflammatory Syndrome in Patients Co‐Infected with Kaposi Sarcoma–Associated Herpesvirus and HIV but without Multicentric Castleman Disease

(2010) Thomas S. Uldrick et al.   CLINICAL INFECTIOUS DISEASES

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine

(2010) Don Ganem   JOURNAL OF CLINICAL INVESTIGATION

Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

(2010) W. Chen et al.   JOURNAL OF VIROLOGY

The De Novo Methyltransferases DNMT3a and DNMT3b Target the Murine Gammaherpesvirus Immediate-Early Gene 50 Promoter during Establishment of Latency

(2010) K. S. Gray et al.   JOURNAL OF VIROLOGY

Bub1 and CENP-F Can Contribute to Kaposi's Sarcoma-Associated Herpesvirus Genome Persistence by Targeting LANA to Kinetochores

(2010) B. Xiao et al.   JOURNAL OF VIROLOGY

Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs

(2010) Y.-T. Lin et al.   RNA

Epigenetic Analysis of KSHV Latent and Lytic Genomes

(2010) Zsolt Toth et al.   PLoS Pathogens

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency

(2010) Grzegorz Sarek et al.   PLoS Pathogens

The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes

(2010) Thomas Günther et al.   PLoS Pathogens

Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis

(2009) Kwun Wah Wen et al.   CANCER LETTERS

Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi's Sarcoma-Associated Herpesvirus and Its Modulation by the Viral Protein Kinase

(2009) P.-C. Chang et al.   CANCER RESEARCH

The Latency-Associated Nuclear Antigen Interacts with MeCP2 and Nucleosomes through Separate Domains

(2009) S. Matsumura et al.   JOURNAL OF VIROLOGY

Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation

(2009) J. Lu et al.   JOURNAL OF VIROLOGY

Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication

(2009) Shara N. Pantry et al.   SEMINARS IN CANCER BIOLOGY

Regulation of the retinoblastoma proteins by the human herpesviruses

(2009) Adam J Hume et al.   Cell Division

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA

(2009) Fang Cheng et al.   PLoS Pathogens

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Interact with the Nuclear Mitotic Apparatus Protein To Regulate Genome Maintenance and Segregation

(2008) H. Si et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF- B-Mediated Suppression of the AP-1 Pathway: a Novel Mechanism of Virus Control of Latency

(2008) F.-C. Ye et al.   JOURNAL OF VIROLOGY

Identification of Direct Transcriptional Targets of the Kaposi's Sarcoma-Associated Herpesvirus Rta Lytic Switch Protein by Conditional Nuclear Localization

(2008) W. Bu et al.   JOURNAL OF VIROLOGY

Dual Regulation of Mad2 Localization on Kinetochores by Bub1 and Dam1/DASH that Ensure Proper Spindle Interaction

(2008) Shigeaki Saitoh et al.   MOLECULAR BIOLOGY OF THE CELL

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

MHC class I assembly: out and about

(2008) Malini Raghavan et al.   TRENDS IN IMMUNOLOGY

Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program

(2008) Qiuhua Li et al.   VIROLOGY

Kaposiʼs sarcoma-associated herpesvirus transmission and primary infection

(2008) Rachel Bagni et al.   Current Opinion in HIV and AIDS

Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways

(2007) Jianping Xie et al.   VIROLOGY