Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 7, Pages 350-355Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.04.005
Keywords
dengue virus; RNA virus; genome cyclisation; viral replication
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Complementary sequences at the 5' and 3' ends of the dengue virus RNA genome are essential for viral replication, and are believed to cyclise the genome through long-range base pairing in cis. Although consistent with evidence in the literature, this view neglects possible biologically active multimeric forms that are equally consistent with the data. Here, we propose alternative multimeric structures, and suggest that multigenome noncovalent concatemers are more likely to exist under cellular conditions than single cyclised monomers. Concatemers provide a plausible mechanism for the dengue virus to overcome the single-stranded (+)-sense RNA virus dilemma, and can potentially assist genome transport from the virus-induced vesicles into the cytosol.
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