Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

PRC2 during vertebrate organogenesis: A complex in transition

(2012) Issam Aldiri et al.   DEVELOPMENTAL BIOLOGY

Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein

(2012) Leo L. Studach et al.   HEPATOLOGY

Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies

(2012) Erin L. Reineke et al.   International Journal of Biological Sciences

Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression

(2012) A Petrelli et al.   ONCOGENE

Switching Polo-like kinase-1 on and off in time and space

(2012) Wytse Bruinsma et al.   TRENDS IN BIOCHEMICAL SCIENCES

Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein

(2012) Siddhartha Rawat et al.   Viruses-Basel

Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

(2012) Altuna Akalin et al.   PLoS Genetics

H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic geneBCL2determines ERα ligand dependency

(2011) Amy Svotelis et al.   EMBO JOURNAL

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

(2011) Sara Toffanin et al.   GASTROENTEROLOGY

Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication

(2011) Wen-Horng Wang et al.   HEPATOLOGY

Dual Functions of Histone-LysineN-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

(2011) Sunwha Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis B virus X gene and hepatocarcinogenesis

(2011) Sue-Ann Ng et al.   JOURNAL OF GASTROENTEROLOGY

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

(2011) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma

(2011) J A Anderton et al.   ONCOGENE

Viral disruption of promyelocytic leukemia (PML) nuclear bodies by hijacking host PML regulators

(2011) Lori Frappier   Virulence

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

Polycomb Group Proteins Set the Stage for Early Lineage Commitment

(2010) Lauren E. Surface et al.   Cell Stem Cell

Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy

(2010) Leo Studach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocellular Carcinoma: Consensus Recommendations of the National Cancer Institute Clinical Trials Planning Meeting

(2010) Melanie B. Thomas et al.   JOURNAL OF CLINICAL ONCOLOGY

Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma

(2010) Jianhua Yin et al.   JOURNAL OF GASTROENTEROLOGY

Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA

(2010) P. Vivekanandan et al.   JOURNAL OF VIROLOGY

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq

(2010) Jing Zhao et al.   MOLECULAR CELL

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Gene signatures in hepatocellular carcinoma (HCC)

(2010) Ourania M. Andrisani et al.   SEMINARS IN CANCER BIOLOGY

Polycomb group protein-mediated repression of transcription

(2010) Lluís Morey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

(2009) Y. Hoshida et al.   CANCER RESEARCH

PML nuclear bodies as sites of epigenetic regulation

(2009) Dora Torok   Frontiers in Bioscience-Landmark

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver

(2009) A. L. Brunner et al.   GENOME RESEARCH

Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression

(2009) Leo L. Studach et al.   HEPATOLOGY

Control of cccDNA function in hepatitis B virus infection

(2009) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

Methylation Regulates Hepatitis B Viral Protein Expression

(2009) Perumal Vivekanandan et al.   JOURNAL OF INFECTIOUS DISEASES

Engagement of the Lysine-Specific Demethylase/HDAC1/CoREST/REST Complex by Herpes Simplex Virus 1

(2009) H. Gu et al.   JOURNAL OF VIROLOGY

Promyelocytic Leukemia Nuclear Bodies Link the DNA Damage Repair Pathway with Hepatitis B Virus Replication: Implications for Hepatitis B Virus Exacerbation during Chemotherapy and Radiotherapy

(2009) Y.-L. Chung et al.   MOLECULAR CANCER RESEARCH

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression

(2008) J Du et al.   CELL DEATH AND DIFFERENTIATION

A concerted action of HNF4α and HNF1α links hepatitis B virus replication to hepatocyte differentiation

(2008) Maria Quasdorff et al.   CELLULAR MICROBIOLOGY

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY

Hepatitis B Virus X Protein Increases the Cdt1-to-Geminin Ratio Inducing DNA Re-replication and Polyploidy

(2008) Lova Rakotomalala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

(2008) Da-Li Zheng et al.   JOURNAL OF HEPATOLOGY

The Two Functions of Herpes Simplex Virus 1 ICP0, Inhibition of Silencing by the CoREST/REST/HDAC Complex and Degradation of PML, Are Executed in Tandem

(2008) H. Gu et al.   JOURNAL OF VIROLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE

Regulation of apoptosis by PML and the PML-NBs

(2008) R Bernardi et al.   ONCOGENE

ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers

(2008) Christian B. Gocke et al.   PLoS One