Hepatitis C Virus and Natural Compounds: A New Antiviral Approach?

(−)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus

(2012) Chao Chen et al.   ARCHIVES OF VIROLOGY

A Cell-Based, Microplate Colorimetric Screen Identifies 7,8-Benzoflavone and Green Tea Gallate Catechins as Inhibitors of the Hepatitis C Virus

(2012) Hidesuke Fukazawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy

(2012) Ming-Ming Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes

(2012) Sibylle Haid et al.   GASTROENTEROLOGY

Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy

(2012) Michael W. Fried   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Hepatitis C therapy in non-genotype 1 patients: the near future

(2012) C. Wartelle-Bladou et al.   JOURNAL OF VIRAL HEPATITIS

Treating hepatitis C: current standard of care and emerging direct-acting antiviral agents

(2012) F. Poordad et al.   JOURNAL OF VIRAL HEPATITIS

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

Hepatitis C virus entry: beyond receptors

(2012) Luke W. Meredith et al.   REVIEWS IN MEDICAL VIROLOGY

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

(2012) Annalisa Bianco et al.   PLoS Pathogens

Intravenous silibinin as ‘rescue treatment’ for on-treatment non-responders to pegylated interferon/ribavirin combination therapy

(2011) Karoline Rutter et al.   ANTIVIRAL THERAPY

Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.

(2011) Yongxin Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry

(2011) Sandra Ciesek et al.   HEPATOLOGY

(−)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry

(2011) Noémie Calland et al.   HEPATOLOGY

A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients

(2011) Gary Deng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism

(2011) Jonathan Goldwasser et al.   JOURNAL OF HEPATOLOGY

Anti-hepatitis C virus activity of 3-hydroxy caruilignan C from Swietenia macrophylla stems

(2011) S.-F. Wu et al.   JOURNAL OF VIRAL HEPATITIS

Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity

(2011) L. Bachmetov et al.   JOURNAL OF VIRAL HEPATITIS

San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression

(2011) J.-C. Lee et al.   JOURNAL OF VIRAL HEPATITIS

Multiple effects of honokiol on the life cycle of hepatitis C virus

(2011) Keng-Hsin Lan et al.   LIVER INTERNATIONAL

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

A new standard of care for the treatment of chronic HCV infection

(2011) Wolf Peter Hofmann et al.   Nature Reviews Gastroenterology & Hepatology

Differential In Vitro Effects of Intravenous versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation

(2011) Jessica Wagoner et al.   PLoS One

(−)-Epigallocatechin gallate inhibits hepatitis C virus (HCV) viral protein NS5B

(2011) Changhyun Roh et al.   TALANTA

Inhibition of HCV 3a core gene through Silymarin and its fractions

(2011) Usman Ashfaq et al.   Virology Journal

Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source

(2011) Y.S. Ravikumar et al.   VIRUS RESEARCH

A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly

(2011) Bertrand Boson et al.   PLoS Pathogens

NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly

(2011) Costin-Ioan Popescu et al.   PLoS Pathogens

Anti-hepatitis C virus activity of Acacia confusa extract via suppressing cyclooxygenase-2

(2010) Jin-Ching Lee et al.   ANTIVIRAL RESEARCH

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

Multiple effects of silymarin on the hepatitis C virus lifecycle

(2010) Jessica Wagoner et al.   HEPATOLOGY

Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV–HCV coinfected patient

(2010) B.A. Payer et al.   JOURNAL OF CLINICAL VIROLOGY

Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy

(2010) U.P. Neumann et al.   JOURNAL OF HEPATOLOGY

Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C

(2010) Sandra Beinhardt et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes

(2010) K. A. Stapleford et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins

(2010) Y. Ma et al.   JOURNAL OF VIROLOGY

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

(2010) Eva Herker et al.   NATURE MEDICINE

Identification of hepatoprotective flavonolignans from silymarin

(2010) S. J. Polyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of infectious hepatitis C virus particles

(2010) Ralf Bartenschlager et al.   TRENDS IN MICROBIOLOGY

Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

(2010) Vlastimil Jirasko et al.   PLoS Pathogens

Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

(2009) Abdelhakim Ahmed–Belkacem et al.   GASTROENTEROLOGY

Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection

(2009) Chihiro Morishima et al.   GASTROENTEROLOGY

The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production

(2009) Oscar Gonzalez et al.   HEPATOLOGY

Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C

(2009) Roy L. Hawke et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

(2009) Alexander Ploss et al.   NATURE

Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus

(2008) C. E. Isaacs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy

(2008) Peter Ferenci et al.   GASTROENTEROLOGY

Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin

(2008) Yaakov Nahmias et al.   HEPATOLOGY

Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

(2008) S. Liu et al.   JOURNAL OF VIROLOGY