Correlation-based prediction of tissue-to-plasma partition coefficients using readily available input parameters

Pak1 as a Novel Therapeutic Target for Antihypertrophic Treatment in the Heart

(2011) Wei Liu et al.   CIRCULATION

Role of phosphatidylserine binding in tissue distribution of amine-containing basic compounds

(2011) Teruo Murakami et al.   Expert Opinion on Drug Metabolism & Toxicology

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

(2011) Rhys Do Jones et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

(2011) C. H. Large et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat

(2011) Helen Graham et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Partition coefficients for nonane and its isomers in the rat

(2010) G. Joshi et al.   TOXICOLOGY MECHANISMS AND METHODS

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

(2009) Karen Rowland Yeo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

(2009) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity

(2007) Rasmus Jansson et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO