Metabolite identification by mass spectrometry: forty years of evolution

A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

(2010) H. Gao et al.   DRUG METABOLISM AND DISPOSITION

Using density functional theory to rationalise the mass spectral fragmentation of maraviroc and its metabolites

(2010) Patricia Wright et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry

(2010) Zhao-Ying Liu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identificationin vitro- amitriptyline and verapamil as model compounds

(2010) Timo Rousu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling

(2010) Gordon J. Dear et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Utilization of DBS within drug discovery: development of a serial microsampling pharmacokinetic study in mice

(2010) Graeme T Clark et al.   Bioanalysis

Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

(2010) Angus NR Nedderman et al.   Bioanalysis

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD

(2009) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Can density functional theory (DFT) be used as an aid to a deeper understanding of tandem mass spectrometric fragmentation pathways?

(2009) Alexander Alex et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

(2008) Filip Cuyckens et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Unique/Major Human Metabolites: Why, How, and When to Test for Safety in Animals

(2008) Debra Luffer-Atlas   DRUG METABOLISM REVIEWS

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

(2008) Bente Gammelgaard et al.   Expert Opinion on Drug Metabolism & Toxicology

Discontinued drugs, 2007: pulmonary-allergy, dermatological, gastrointestinal and arthritis drugs

(2008) Sabina A Antoniu   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Rapid analysis of pharmaceuticals and excreted xenobiotic and endogenous metabolites with atmospheric pressure infrared MALDI mass spectrometry

(2008) Bindesh Shrestha et al.   Metabolomics

Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

(2008) J. M. Wiseman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a ‘first-line’ approach for metabolite identification studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Applications of Metabolomics in Drug Discovery and Development

(2008) David S Wishart   Drugs in research & development