Review
Biochemistry & Molecular Biology
Xiaoping Song, Lina Wang, Daidi Fan
Summary: This review provides a comprehensive summary of the potential health benefits and molecular mechanisms of ginsenoside Rd, a major bioactive compound found in Panax ginseng. While numerous studies have been conducted on the pharmacological activities of Rd, specific clinical evidence is still limited. Future research should consider conducting clinical trials to further evaluate the therapeutic potential of Rd.
Review
Plant Sciences
Barkha Ravi, Christine H. Foyer, Girdhar K. Pandey
Summary: Reactive oxygen species (ROS) and calcium (Ca2+) signalling play important roles in plant growth, development, and defense. They function together with electric signals in directional cell-to-cell systemic signalling and even plant-to-plant communication. However, there is still limited understanding of the molecular mechanisms underlying the management of ROS and Ca2+ signals, as well as the synchronous and independent signaling in different cellular compartments. This review focuses on the proteins that may connect different pathways during abiotic stress responses, and highlights the crosstalk between ROS and Ca2+ pathways in cell signaling.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Francesca Aglialoro, Asena Abay, Nurcan Yagci, Minke A. E. Rab, Lars Kaestner, Richard van Wijk, Marieke von Lindern, Emile van den Akker
Summary: In this study, we found that PIEZO1 acts as a mechanosensor that, when transferred to orbital shaking, activates signaling cascades that are Ca2+-dependent, regulating various aspects of erythropoiesis. This suggests that there are direct physiological outcomes of mechanical stress on erythroblasts, as shown by the comparable activation of some Ca2+-dependent pathways induced by Yoda1 treatment and mechanical stress via orbital shaking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin Hye Chung, Jinhong Wie
Summary: Bioceramics, such as calcium-phosphate-based materials, are used in medical and dental implants for bone tissue replacement or repair. The effect of bioceramic sintering on intracellular signaling pathways is still unknown. This study analyzed the impact of sintering on osteoblast cell signaling pathways using sintered and non-sintered hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). The findings showed that sintering affects multiple signaling pathways, providing insights into bioceramic function and expanding their application scope in clinical settings.
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Brendan Elsworth, Manoj T. Duraisingh
Summary: Babesia species are tick-borne parasites that infect mammalian red blood cells, causing severe diseases. They have complex life cycles involving multiple stages in both ticks and mammalian hosts, utilizing intricate signaling pathways for replication, egress, and invasion. Understanding the signaling pathways and environmental stimuli used by Babesia species during transmission is crucial for further biological and translational studies of these parasites.
MOLECULAR MICROBIOLOGY
(2021)
Article
Plant Sciences
Kyle Symonds, Howard Teresinski, Bryan Hau, David Chiasson, Kirsten Benidickson, William Plaxton, Wayne A. Snedden
Summary: Calmodulin-like proteins (CMLs) are the largest family of calcium-binding proteins in plants. The study found that CML13 and CML14 play important roles in plant development, regulating development and morphological features through interactions with other proteins. Inhibition of CML13 or CML14 transcript levels leads to abnormal plant development, including difficulties in germination, chlorosis, and leaf senescence.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jing Li, Qingxia Huang, Yao Yao, Peng Ji, E. Mingyao, Jinjin Chen, Zepeng Zhang, Hongyu Qi, Jiaqi Liu, Zhaoqiang Chen, Daqing Zhao, Lei Zhou, Xiangyan Li
Summary: Panax ginseng has a long history and its active compound ginsenosides have shown significant biological activities in various diseases, especially in neurological diseases, cancer, and metabolic diseases. Ginsenoside Rd has potential therapeutic effects in preventing ischemic stroke, nerve injury, cancer, and other diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jing Li, Qingxia Huang, Yao Yao, Peng Ji, E. Mingyao, Jinjin Chen, Zepeng Zhang, Hongyu Qi, Jiaqi Liu, Zhaoqiang Chen, Daqing Zhao, Lei Zhou, Xiangyan Li
Summary: This article introduces the important biological activities of Panax ginseng and its main active component, ginsenoside Rd, in neurological diseases, cancer, metabolic diseases, etc. The study explores the mechanisms of action of ginsenoside Rd in various diseases and discusses the main biotransformation pathways of ginsenoside Rd.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaotong Shi, Jinyu Bao, Xu Lu, Lei Ma, Yi Zhao, Shimin Lan, Jie Cao, Shaoying Ma, Sheng Li
Summary: Ca2+ is an essential metal ion for plant growth and development, playing important roles in plant signal transduction and metabolic processes. This review summarizes the mechanisms of Ca2+ response to stress signals, the regulation of ion transport, the interaction with phytohormones, and the role of calcium-dependent proteins in stress response.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Review
Plant Sciences
Yu-Ying Chen, Qiu-Ping Liu, Pei An, Min Jia, Xin Luan, Jian-Yuan Tang, Hong Zhang
Summary: Ginsenoside Rd is an active compound with broad pharmacological effects that can reduce neurological damage and provide neuroprotection. It exerts its effects through anti-inflammatory, antioxidant, anti-apoptotic, inhibition of Ca2+ influx, and protection of mitochondria pathways, inhibiting excitatory toxicity, regulating nerve growth factors, and promoting nerve regeneration.
Article
Biology
Eider Nunez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel, Henry M. Colecraft
Summary: Neuronal K(V)7 channels are highly sensitive to reactive oxygen species, and the S2S3 linker of the voltage sensor plays a crucial role in redox modulation of the channels. Recent structural studies have revealed interactions between this linker and the Ca2+-binding loop of calmodulin, specifically the EF3 hand, which is essential for the signaling. Disrupting Ca2+ binding to EF3 abolishes the oxidation-induced enhancement of K(V)7.4 currents. Furthermore, the loading of EF3 with Ca2+ is critical for the reorientation of the AB fork, which translates the Ca2+ signals.
Article
Plant Sciences
Maria Stolarz, Kazimierz Trebacz
Summary: This study observed the movements and action potentials of Mimosa pudica L. plants, revealing spontaneous rapid leaf movements and action potentials in intact plants, with a delay between the appearance of action potential and leaf movement, suggesting that action potentials may trigger the rapid leaf movements.
PHYSIOLOGIA PLANTARUM
(2021)
Review
Immunology
Nicholas Manolios, John Papaemmanouil, David Adams
Summary: T lymphocytes are crucial cells in the immune system, and ion channels play a critical role in regulating their function. This review summarizes the impact of ion channels on T cell function and disease, emphasizing their potential as drug targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hai Huang, Wei Zhou, Haiyan Zhu, Pei Zhou, Xunlong Shi
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Xincheng Zhang, Meiqing Fen, Xunlong Shi, Linquan Bai, Pei Zhou
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2008)
Article
Biotechnology & Applied Microbiology
Xunlong Shi, Zhihui Shi, Hai Huang, Hongguang Zhu, Haiyan Zhu, Dianwen Ju, Pei Zhou
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2013)
Article
Biochemical Research Methods
Xunlong Zhong, Jiao Guo, Laiyou Wang, Duosheng Luo, Weijian Bei, Yuanyuan Chen, Kangqi Yan, Junhui Peng
Article
Pharmacology & Pharmacy
Meiqing Feng, Qinsheng Cai, Xunlong Shi, Hai Huang, Pei Zhou, Xin Guo
JOURNAL OF DRUG TARGETING
(2008)
Article
Biochemical Research Methods
Xincheng Zhang, Yun Bao, Xunlong Shi, Xijun Ou, Pei Zhou, Xiaoming Ding
JOURNAL OF MICROBIOLOGICAL METHODS
(2012)
Article
Plant Sciences
Yuan-zhen Hao, Li-feng Cen, Ting Wang, Tong Yi, Xun-long Shi, Hui-juan Duan, Zhi Dai, Hai-yan Zhu, Jian-guo Tang
Summary: This study investigated the therapeutic effect of 999 XiaoErGanMao granules (XEGMG) on lung and intestine injury in H1N1 influenza virus-infected mice. The results showed that XEGMG can mitigate body weight loss, reduce lung index and pathological damage, and decrease the release of inflammatory cytokines. XEGMG can also protect goblet cells in the colon, maintain intestinal barrier, and regulate the major flora.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemical Research Methods
W Yong, XL Shi, ZY Yuan, Z Pei
PROTEIN EXPRESSION AND PURIFICATION
(2004)
Article
Biotechnology & Applied Microbiology
Xunlong Shi, Meiqing Feng, Yujie Zhao, Xin Guo, Pei Zhou
BIOTECHNOLOGY LETTERS
(2008)
Article
Chemistry, Medicinal
CW Sun, H Huang, MQ Feng, XL Shi, XD Zhang, P Zhou
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2006)
