ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

(2017) Aleksandra Adamska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer

(2017) Pavel Dvorak et al.   TUMOR BIOLOGY

Epithelial-Mesenchymal Transition in Pancreatic Cancer: A Review

(2017) Shuai Wang et al.   Biomed Research International

Downregulation of ABC Transporters in Non-neoplastic Tissues Confers Better Prognosis for Pancreatic and Colorectal Cancer Patients

(2017) Pavel Dvorak et al.   Journal of Cancer

Pancreatic cancer: Current research and future directions

(2016) Marco Falasca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multidrug Resistance Proteins (MRPs) and Cancer Therapy

(2015) Yun-Kai Zhang et al.   AAPS Journal

Providing a molecular mechanism for P-glycoprotein; why would I bother?

(2015) R. Callaghan   BIOCHEMICAL SOCIETY TRANSACTIONS

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Gemcitabine and S-1 combination chemotherapy versus gemcitabine alone for locally advanced and metastatic pancreatic cancer: a meta-analysis of randomized controlled trials in Asia

(2015) Yanxun Li et al.   JOURNAL OF CHEMOTHERAPY

Pancreatic cancer: from state-of-the-art treatments to promising novel therapies

(2015) Ignacio Garrido-Laguna et al.   Nature Reviews Clinical Oncology

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastatic pancreatic cancer: Is there a light at the end of the tunnel?

(2015) Vanja Vaccaro   WORLD JOURNAL OF GASTROENTEROLOGY

Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells

(2015) Wolfgang Hagmann et al.   NEOPLASIA

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

(2014) Tianmeng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

(2014) Emily L. Ruban et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The complex landscape of pancreatic cancer metabolism

(2014) C. M. Sousa et al.   CARCINOGENESIS

Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Human Pancreatic Cancer Stem Cells: Implications for How We Treat Pancreatic Cancer

(2014) Cheong J. Lee et al.   Translational Oncology

Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

(2014) Julian Swierczynski   WORLD JOURNAL OF GASTROENTEROLOGY

Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase

(2014) Lawrence M Knab   WORLD JOURNAL OF GASTROENTEROLOGY

Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)

(2014) CHONG DI et al.   Experimental and Therapeutic Medicine

Rationally designed nanovehicles to overcome cancer chemoresistance

(2013) Yoav D. Livney et al.   ADVANCED DRUG DELIVERY REVIEWS

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Biology and Clinical Applications of Pancreatic Cancer Stem Cells

(2013) Ethan V. Abel et al.   GASTROENTEROLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution and dynamics of pancreatic cancer progression

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Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues

(2013) Beatrice Mohelnikova-Duchonova et al.   PANCREAS

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of molecular and cellular medicine to solid tumors

(2012) Rakesh K. Jain   ADVANCED DRUG DELIVERY REVIEWS

Mitochondrial ABC transporters function: The role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species

(2012) Marc Liesa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?

(2012) Man Yu et al.   CANCER AND METASTASIS REVIEWS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Expression of the 49 human ATP binding cassette (ABC) genes in pluripotent embryonic stem cells and in early- and late-stage multipotent mesenchymal stem cells

(2012) Romain Barbet et al.   CELL CYCLE

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1

(2012) Jean-Pierre Gillet et al.   DRUG RESISTANCE UPDATES

Investigational ABC transporter inhibitors

(2012) Marco Falasca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

(2012) Xue Xue et al.   Chinese Journal of Cancer

ABC Proteins Protect the Human Body and Maintain Optimal Health

(2011) Kazumitsu UEDA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Improving Cancer Chemotherapy with Modulators of ABC Drug Transporters

(2011) S. Shukla et al.   CURRENT DRUG TARGETS

Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy

(2011) Amit K. Tiwari et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mammalian multidrug-resistance proteins (MRPs)

(2011) Andrew J. Slot et al.   Essays in Biochemistry

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Drug transporter expression in human macrophages

(2011) Amélie Moreau et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients

(2011) C. Marzac et al.   HAEMATOLOGICA

Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study

(2011) Hedy L Kindler et al.   LANCET ONCOLOGY

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion and side populations

(2010) F Wang et al.   BRITISH JOURNAL OF CANCER

MicroRNA and drug resistance

(2010) J Ma et al.   CANCER GENE THERAPY

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

(2010) Elisa Giovannetti et al.   CANCER RESEARCH

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

Drug Efflux Transporter Multidrug Resistance-Associated Protein 5 Affects Sensitivity of Pancreatic Cancer Cell Lines to the Nucleoside Anticancer Drug 5-Fluorouracil

(2010) P. K. Nambaru et al.   DRUG METABOLISM AND DISPOSITION

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance

(2010) Zhiwei Wang et al.   DRUG RESISTANCE UPDATES

Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin

(2010) Sara Vander Borght et al.   LIVER INTERNATIONAL

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer

(2010) Jin-Hyeok Hwang et al.   PLoS One

Membrane Drug Transporters and Chemoresistance in Human Pancreatic Carcinoma

(2010) Wolfgang Hagmann et al.   Cancers

Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance

(2009) Ye-Hong Kuang et al.   BIOCHEMICAL PHARMACOLOGY

Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2

(2009) Chun-ling Dai et al.   CANCER LETTERS

Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier

(2009) Bernd Dörner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The ABC of dendritic cell development and function

(2009) Rieneke van de Ven et al.   TRENDS IN IMMUNOLOGY

Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy

(2008) Kohji Noguchi et al.   ADVANCED DRUG DELIVERY REVIEWS

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

(2008) Hua Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

(2008) Ruoping Tang et al.   BMC CANCER

Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

(2008) C.-l. Dai et al.   CANCER RESEARCH

An overview of cancer multidrug resistance: a still unsolved problem

(2008) H. Lage   CELLULAR AND MOLECULAR LIFE SCIENCES

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Reversal of Drug Resistance in Ovarian Cancer: Where Do We Go From Here?

(2008) Stan B. Kaye   JOURNAL OF CLINICAL ONCOLOGY

Phase III Study of Valspodar (PSC 833) Combined With Paclitaxel and Carboplatin Compared With Paclitaxel and Carboplatin Alone in Patients With Stage IV or Suboptimally Debulked Stage III Epithelial Ovarian Cancer or Primary Peritoneal Cancer

(2008) Catherine Lhommé et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

ATP-Binding Cassette C Transporters in Human Pancreatic Carcinoma Cell Lines

(2008) Wolfgang Hagmann et al.   PANCREATOLOGY

P-glycoprotein: So Many Ways to Turn It On

(2007) Richard Callaghan et al.   JOURNAL OF CLINICAL PHARMACOLOGY