Article
Medicine, Research & Experimental
Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng
Summary: This study demonstrates that the L.p R3 strain significantly improves symptoms and pathological damage in mice with colitis, and influences immune function by regulating the Th17/Treg cell balance in DSS-induced colitis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Rong Ren, Ai-Qing Zhao, Li Chen, Shan Wu, Wei-Lun Hung, Bini Wang
Summary: In this study, Lactobacillus plantarum JS19 isolated from jiang-shui exhibited strong antioxidant activity. Oral administration of L. plantarum JS19 effectively prevented body weight loss, colon shortening and damage in mice with dextran sulfate sodium-induced colitis. Moreover, L. plantarum JS19 alleviated inflammatory responses, oxidative stress, and rebalanced dysbiosis of gut microbiota. Therefore, L. plantarum JS19 may serve as a promising probiotic for preventing inflammatory bowel disease, specifically ulcerative colitis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Tiantian Hu, Yang Fan, Xingyao Long, Yanni Pan, Jianfei Mu, Fang Tan, Xin Zhao
Summary: The study demonstrated that LP-YS3 has a significant protective effect on UC mice, reducing disease activity index, inhibiting colon shortening, and improving inflammatory markers. LP-YS3 also increased GSH content and upregulated specific gene expression levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Zhenlan Feng, Ying Cheng, Yuedong Wang, Shugen Qu, Jicong Du, Fu Gao, Cong Liu, Qi Wang, Jianming Cai
Summary: The incidence of inflammatory bowel disease (IBD) is increasing, but its etiology remains unclear and there is no effective and low-toxic therapeutic drug available. The PHD-HIF pathway is being explored for its potential role in relieving DSS-induced colitis.
Article
Immunology
Shao Rong Long, Ruo Dan Liu, Deepak Vijaya Kumar, Zhong Quan Wang, Chien-Wen Su
Summary: A newborn larvae-specific serine protease from Trichinella spiralis shows therapeutic potential in reducing severity of intestinal inflammation and disease index, suppressing macrophage infiltration, reducing TNF-alpha secretion, and inducing IL-10 expression in a DSS-induced colitis model. Immunotherapy with this protease holds promise as an additional strategy to modulate inflammatory processes involved in IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Boonyarut Ladda, Chittapon Jantararussamee, Wisuit Pradidarcheep, Anongnard Kasorn, Udomlak Matsathit, Malai Taweechotipatr
Summary: This study examined the properties of three probiotic strains in colorectal adenocarcinoma cells. It was found that the probiotic L. paracasei strain MSMC39-1 significantly suppressed TNF-a secretion in the cells. Further experiments showed that this strain reduced liver enzyme levels, inhibited TNF-a secretion in colon and liver tissues, alleviated colon and liver histopathology, and increased beneficial bacteria in the gut.
Article
Immunology
Yao Kong, Zhaoxia Liu, Qin Xiao, Fei Wu, Lijuan Hu, Xiaorong Deng, Tingtao Chen
Summary: In this study, L. crispatus-pMG36e-mCXCL12 strain was found to effectively alleviate and prevent intrauterine adhesions by modulating the inflammatory and fibrotic signaling pathways, and restoring the microbial balance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sze Wing Ho, Hani El-Nezami, Harold Corke, Chun Sing Ho, Nagendra P. Shah
Summary: The study showed that the combination of L. helveticus and citrulline had a significant synergistic effect in protecting against injury from DSS-induced colitis. This combination therapy could be a potential treatment for IBD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei, Pei Jiang
Summary: This study aimed to evaluate the utility metabolomic analysis of target tissues in exploring new biomarkers for early diagnosis and treatment of IBD. The results showed significant changes in amino acid, organic acid, glucide, and purine profiles, impacting pathways ranging from amino acid metabolism to purine metabolism. Using GC-MS-based profiling of metabolite changes may provide a more comprehensive view for understanding IBD pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Bihui Liu, Lei Yang, Ya Wu, Xin Zhao
Summary: This study investigated the effects of Limosilactobacillus fermentum HFY06 (LF-HFY06) on murine colitis. The results showed that LF-HFY06 increased colon length and ameliorated pathological damage, enhanced antioxidant enzyme activities, reduced inflammatory cytokine levels, and inhibited inflammation through the NF-κB signaling pathway. LF-HFY06 has the potential to prevent and treat colitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ui-Jin Bae, Ha-Na Jang, Sung-Hyen Lee, Ji-Young Kim, Gi-Chang Kim
Summary: The study investigated the anti-inflammatory and antioxidant effects of Oenanthe javanica ethanol extract (OJE) in mice with DSS-induced colitis. Results showed that OJE treatment reduced inflammation, protected the colon, and modulated gut microbial composition, suggesting potential benefits for colitis treatment.
Article
Biochemistry & Molecular Biology
Jiahui Zheng, Huan Li, Pei Zhang, Shijun Yue, Bingtao Zhai, Junbo Zou, Jiangxue Cheng, Chongbo Zhao, Dongyan Guo, Jing Wang
Summary: This study investigated the effects of paeonol (Pae) on colonic inflammation in a mouse model of ulcerative colitis (UC). The results showed that Pae significantly improved the clinical symptoms of UC, restored the integrity of the intestinal epithelial barrier, and regulated the composition of the gut microbiota and metabolites.
Article
Biochemistry & Molecular Biology
Tobias Hasler, Leticia Tavares-Gomes, Sereina Gut, Meghna Swayambhu, Mario Gysi, Martin Hausmann, Natasha Arora, Thierry Hennet
Summary: The availability of carbohydrates in the gastrointestinal tract influences the gut microbiota composition. Bacterial glycoside hydrolases play a role in carbohydrate foraging and can alter the properties of host glycans. Increased sialidase activity exacerbates acute colitis severity by remodeling surface sialylation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Medicinal
Ahmed M. Kabel, Aliaa Atef, Hany M. Borg, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, Hany H. Arab, Remon S. Estfanous
Summary: This study investigated the effects of perindopril and ambrosin, alone or in combination, on DSS-induced colitis in mice. The results showed that both perindopril and ambrosin were able to alleviate oxidative stress, suppress proinflammatory pathways, inhibit apoptosis, and enhance autophagy in colonic tissues. The combination of perindopril and ambrosin had the most remarkable effects compared to either agent alone.