Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development

Obesity-associated mechanisms of hepatocarcinogenesis

(2014) Raffi Karagozian et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Multifaceted roles of Adiponectin in cancer

(2013) Lionel Hebbard et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis

(2013) Hitoshi Endo et al.   PLoS One

Obesity, insulin resistance, NASH and hepatocellular carcinoma

(2013) Jun Yu et al.   SEMINARS IN CANCER BIOLOGY

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

(2012) Danielle A.A. Hollman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?

(2012) David van der Poorten et al.   HEPATOLOGY

The promoting effect of adiponectin in hepatocellular carcinoma

(2012) Ming-Jenn Chen et al.   JOURNAL OF SURGICAL ONCOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

(2012) Andrea Mencarelli et al.   PLoS One

Inflammation- and stress-related signaling pathways in hepatocarcinogenesis

(2012) Hayato Nakagawa   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of oxidative stress in non-alcoholic steatohepatitis

(2011) G.H. Koek et al.   CLINICA CHIMICA ACTA

Insulin Resistance and Other Metabolic Risk Factors in the Pathogenesis of Hepatocellular Carcinoma

(2011) Asma Siddique et al.   Clinics in Liver Disease

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

(2011) Janne Prawitt et al.   Current Diabetes Reports

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

(2011) Michele Malaguarnera et al.   DIGESTIVE DISEASES AND SCIENCES

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Recent trend of clinical features in patients with hepatocellular carcinoma

(2011) Yuko Nagaoki et al.   HEPATOLOGY RESEARCH

Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

(2011) A. Wolfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

FXR and PXR: Potential therapeutic targets in cholestasis

(2011) Johan W. Jonker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Suppression of Liver Tumor Growth and Metastasis by Adiponectin in Nude Mice through Inhibition of Tumor Angiogenesis and Downregulation of Rho Kinase/IFN-Inducible Protein 10/Matrix Metalloproteinase 9 Signaling

(2010) K. Man et al.   CLINICAL CANCER RESEARCH

Population-based risk factors and resource utilization for HCC: US perspective

(2010) A. Sanyal et al.   CURRENT MEDICAL RESEARCH AND OPINION

Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8

(2010) Ahmed Abu Shanab et al.   DIGESTIVE DISEASES AND SCIENCES

Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and Inhibits Hepatocellular Carcinoma

(2010) Neeraj K. Saxena et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Inflammation and Liver Cancer

(2009) C. Berasain et al.   Annals of the New York Academy of Sciences

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

(2009) Arumugam Velayudham et al.   HEPATOLOGY

Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis

(2009) Natsuko Kawada et al.   JOURNAL OF GASTROENTEROLOGY

Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2009) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY

Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis

(2009) Takeharu Asano et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

(2009) Songwen Zhang et al.   JOURNAL OF HEPATOLOGY

Endocrine and liver interaction: the role of endocrine pathways in NASH

(2009) Paola Loria et al.   Nature Reviews Gastroenterology & Hepatology

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function

(2008) Eran Elinav et al.   HEPATOLOGY

Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury

(2008) Mingyan Zhou et al.   HEPATOLOGY

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

(2008) Chun-Jen Liu et al.   Hepatology International

Role of Toll-like receptors in gastrointestinal malignancies

(2008) M Fukata et al.   ONCOGENE

Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma

(2008) Domenico Ribatti et al.   PEPTIDES

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

(2008) Willscott E. Naugler et al.   TRENDS IN MOLECULAR MEDICINE