Article
Agriculture, Multidisciplinary
Yunika Mayangsari, Natsumi Sugimachi, Wenxi Xu, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study demonstrated that 3,5,7,3',4'- pentamethoxyflavone (PMF) can enhance the intestinal tight junction (TJ) barrier integrity by regulating the transcription of TJ proteins, such as occludin, claudin-3, and claudin-4.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Shizhe Yu, Haoren Wang, Lingpeng Yang, Yingxue Yan, Qiang Cai, Duo Ma, Long Jiang, Zehai Gao, Zhiyong Yu, Zongping Xia
Summary: The comprehensive study of the spatial-cellular anatomy of the human liver is crucial for understanding the cellular origins of liver disease. In this study, spatial transcriptomics were conducted on normal human liver tissue sections, providing detailed transcriptional information on liver zonation. A total of 6581 high-quality spots from normal livers were analyzed, mainly consisting of hepatocytes, which were classified into four sub-groups. These data serve as a reliable reference for studying the spatial heterogeneity of liver lobules.
Article
Chemistry, Multidisciplinary
Nisreen Faizo, Chandrakala Aluganti Narasimhulu, Anna Forsman, Shibu Yooseph, Sampath Parthasarathy
Summary: The study revealed that treatment with 13-HPODE induced the expression of genes related to detoxification and metabolic pathways in PDiff Caco-2 cells, while downregulating some proliferation-related genes. Additionally, 13-HPODE was found to impact ribosome biogenesis, phagosome, and mitochondrial function, potentially contributing to disease development or progression.
APPLIED SCIENCES-BASEL
(2021)
Review
Cell Biology
Evangelia C. Tachmatzidi, Ourania Galanopoulou, Iannis Talianidis
Summary: During liver organogenesis, a series of hepatic transcriptional regulators reshape cellular transcription profiles to activate hepatic genes. Pioneer factors open highly condensed chromatin to facilitate the action of other transcription factors. The bookmarking mechanism provides transcriptional competence for future activation of target genes, accompanied by a dynamic maturation process preparing for stable and efficient transcription.
Article
Physiology
Jeffrey B. Warner, Ida S. Larsen, Josiah E. Hardesty, Ying L. Song, Dennis R. Warner, Craig J. McClain, Rui Sun, Zhongbin Deng, Benjamin A. H. Jensen, Irina A. Kirpich
Summary: This study investigates the effects of human beta defensin-2 (hBD-2) on alcohol-associated liver disease (ALD). The results show that oral administration of hBD-2 can attenuate liver injury, decrease liver steatosis, hepatocellular death, and inflammation. Furthermore, hBD-2 can modulate the gut microbiota composition, and this protective effect is associated with immunomodulation and microbiota alteration.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Chenxi Zhang, Conghui Li, Ling Yang, Lizhi Leng, Dragomirka Jovic, Jun Wang, Fang Fang, Guibo Li, Depeng Zhao, Xuemei Li, Lin Lin, Yonglun Luo, Lars Bolund, Jinrong Huang, Ge Lin, Fengping Xu
Summary: Previous studies have shown that transcription factors (TFs) play important roles in biparental early human embryogenesis. This study systematically studied the expression profiles of TFs in early embryonic development and revealed the dynamic changes of TFs in human biparental and uniparental embryogenesis through single-cell RNA sequencing. The results indicate that shared and specific TFs contribute to stem cell maintenance and differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Xiaomeng Ding, Xiaoyi Hu, Yi Chen, Jianhua Xie, Mengxi Ying, Yudan Wang, Qiang Yu
Summary: With a focus on the differentiated Caco-2 cell model, this review highlights its current applications as a specialized model for intestinal cells in vitro, and explores new approaches to overcome challenges in utilization for guiding future trends in food-intestine interaction research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Stephen O'Rahilly
Summary: The 2021 Gairdner Prize was awarded to Daniel Drucker, Joel Habener, and Jens Juul Holst for their discovery of novel peptides encoded in the proglucagon sequence and the establishment of their physiological roles. These discoveries have led to the development of therapeutics that are currently benefiting patients with type 2 diabetes and other disorders worldwide.
Article
Cell & Tissue Engineering
Jitske Jansen, Katharina C. Reimer, James S. Nagai, Finny S. Varghese, Gijs J. Overheul, Marit de Beer, Rona Roverts, Deniz Daviran, Liline A. S. Fermin, Brigith Willemsen, Marcel Beukenboom, Sonja Djudjaj, Saskia von Stillfried, Larissa E. van Eijk, Mirjam Mastik, Marian Bulthuis, Wilfred den Dunnen, Harry van Goor, Jan-Luuk Hillebrands, Sergio H. Triana, Theodore Alexandrov, Marie-Cherelle Timm, Bartholomeus T. van den Berge, Martijn van den Broek, Quincy Nlandu, Joelle Heijnert, Eric M. J. Bindels, Remco M. Hoogenboezem, Fieke Mooren, Christoph Kuppe, Pascal Miesen, Katrien Grunberg, Ties Ijzermans, Eric J. Steenbergen, Jan Czogalla, Michiel F. Schreuder, Nico Sommerdijk, Anat Akiva, Peter Boor, Victor G. Puelles, Juergen Floege, Tobias B. Huber, Ronald P. van Rij, Ivan G. Costa, Rebekka K. Schneider, Bart Smeets, Rafael Kramann
Summary: The study found that SARS-CoV-2 can directly infect kidney cells, leading to cell injury and fibrosis, causing kidney failure. Inhibitors can alleviate the infection.
Article
Plant Sciences
Fan Qi, Fu Wang, Chunxiao Xiaoyang, Zhenhui Wang, Yujie Lin, Zhanwu Peng, Jun Zhang, Ningning Wang, Jian Zhang
Summary: This study conducted transcriptome analysis to analyze the gene expression profiles of different organs in flax. The results identified differentially expressed genes and organ-specific expression patterns. Gene ontology enrichment analysis revealed the biological processes and molecular functions associated with organ growth. The study also investigated the role of AP2 transcription factors in regulating flax organ development and stress response. Overall, this research provides valuable insights into the molecular mechanisms of flax organ development and has implications for genetic improvement of flax crops.
Review
Biochemistry & Molecular Biology
Mengyuan Wang, Qian Li, Lingbo Liu
Summary: Gene expression regulation involves multiple processes and various regulatory factors. This review provides an overview of key factors involved in gene expression regulation, such as transcription factors, chromatin accessibility, histone modifications, DNA methylation, and RNA modifications. Additionally, methods for detecting these regulatory factors are also described.
Article
Environmental Sciences
Oceane Reale, Antoine Huguet, Valerie Fessard
Summary: This study evaluated the toxic effects of four lipophilic phycotoxins on Caco-2/HT29-MTX co-cultured cells, revealing that these toxins can reduce cell viability, affect monolayer integrity, and have different impacts on cell types and mucus production. Cell models integrating multiple cell types may improve hazard characterization and provide more accurate descriptions of the modes of action of phycotoxins.
Article
Gastroenterology & Hepatology
Huihui Ren, Fuqing Hu, Dan Wang, Xiaonan Kang, Xiaohui Feng, Lu Zhang, Bowen Zhou, Siyue Liu, Gang Yuan
Summary: The study demonstrates that SIRT2 functions as a crucial negative regulator in NAFLD and related metabolic disorders by targeting the HNF4 alpha pathway. Restoring hepatic SIRT2 expression can alleviate metabolic dysfunctions associated with NAFLD.
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Genetics & Heredity
Qiao Liu, Kui Hua, Xuegong Zhang, Wing Hung Wong, Rui Jiang
Summary: DeepCAGE is a deep learning framework that accurately predicts chromatin accessible regions in a variety of cell types, and exhibits superior performance in the classification and regression of chromatin accessibility signals.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)