Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Guadalupe Garcia-Tsao
Summary: NASH has become the main cause of cirrhosis and liver transplantation, unlike hepatitis C which is a liver-specific disorder. It is a complex metabolic disorder that requires finding alternative therapies and defining response to treatment, with diagnosis established through liver biopsy samples.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ilaria Umbro, Francesco Baratta, Francesco Angelico, Maria Del Ben
Summary: NAFLD is associated with extrahepatic manifestations like cardiovascular disease and sleep apnea, as well as an increased risk of incident CKD. Inflammation and oxidative stress play key roles in linking NAFLD to CKD. Studies show that CKD develops more frequently in NAFLD patients, persisting even after adjusting for risk factors and severity of NAFLD, emphasizing the need for multidisciplinary surveillance and early treatment for these patients.
Review
Gastroenterology & Hepatology
Gwyneth Soon, Aileen Wee
Summary: Accurate assessment of liver fibrosis is crucial in predicting disease outcomes and evaluating therapeutic response in NAFLD/NASH. While histological assessment remains the gold standard, advances in SHG/TPEF microscopy imaging show promise in providing more detailed measurement. The application of artificial intelligence can further refine quantitative fibrosis scoring methods.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: Dr. Xiao et al. found no association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with incident dementia and cognition. Interestingly, there was a lower risk of incident dementia in the first 5 years after NAFLD diagnosis. The authors suggest that this may simply reflect the absence of weight loss rather than any true protective effect against dementia.
Review
Immunology
Ke-qian Chen, Bo-yi Ke, Lu Cheng, Xiao-qing Yu, Zong-bao Wang, Shu-zhi Wang
Summary: With the development of the social economy, unhealthy living habits and eating styles are gradually affecting people's health in recent years. NAFLD, as a chronic liver disease, has become an increasingly serious public health problem due to these factors. Inflammasomes, as a protein complex, play a crucial role in the development of NAFLD and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
George Agyapong, Farzaneh Dashti, Bubu A. A. Banini
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. This manuscript provides an overview of NAFLD risk factors, natural history, diagnosis, and current management strategies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Hye Ah Lee, Seo Yeong Oh, Hyo Jeong Baek, Jae Won Moon, Yeon Jeong Kim, Jinha Lee, Hyoeun Kim, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Seung Up Kim
Summary: This study investigated the association of physical activity with risk of liver fibrosis, sarcopenia, and cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD) subjects. The study found that increasing levels of physical activity were associated with a reduced risk of fibrosis, sarcopenia, and CVD. Furthermore, higher levels of physical activity were also associated with a lower risk of fibrosis, sarcopenia, and CVD in subjects with sarcopenic obesity or lean NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Thaninee Prasoppokakorn, Wah-Kheong Chan, Vincent Wai-Sun Wong, Panyavee Pitisuttithum, Sanjiv Mahadeva, Nik Raihan Nik Mustapha, Grace Lai-Hung Wong, Howard Ho-Wai Leung, Pimsiri Sripongpun, Sombat Treeprasertsuk
Summary: This study validated the superiority of the FIB-8 score in predicting significant fibrosis in NAFLD patients in an Asian population compared to the NFS and FIB-4 score. The study suggests that a simple fibrosis score comprising commonly accessible basic laboratories may be beneficial for an initial assessment in primary care units and aiding in patient selection for further hepatologist referral.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Endocrinology & Metabolism
Sarah Beland-Bonenfant, Alexia Rouland, Jean-Michel Petita, Bruno Verges
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide. Lipidomic studies have been used to understand the pathophysiology of NAFLD and identify potential biomarkers. Lipidomic abnormalities associated with NAFLD include changes in free fatty acid distribution, increased ceramides, reduced phosphatidylcholine/phosphatidylethanolamine ratio, and increased eicosanoids. These lipid abnormalities may contribute to NASH and liver fibrosis by inducing mitochondrial dysfunction, apoptosis, inflammation, oxidation, and endoplasmic reticulum stress. Further research is needed to determine their predictive value for liver steatosis, NASH, or liver fibrosis.
DIABETES & METABOLISM
(2023)
Article
Medicine, General & Internal
Pei-Chia Yen, Yu-Tsung Chou, Chung-Hao Li, Zih-Jie Sun, Chih-Hsing Wu, Yin-Fan Chang, Feng-Hwa Lu, Yi-Ching Yang, Chih-Jen Chang, Jin-Shang Wu
Summary: This study investigated the relationship between hyperuricemia and liver fibrosis and found that hyperuricemia increased the associated risk of significant liver fibrosis. This positive association was observed in subjects with NAFLD, but not in those without it.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Christoph G. Dietrich, Monika Rau, Andreas Geier
Summary: NAFLD is a common liver disease, especially prevalent in patients with metabolic syndrome and in Western countries. Complications include fibrosis, cirrhosis, hepatocellular carcinoma, as well as increased risk for cardiovascular disease, extrahepatic neoplasia, and other organ damage.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Hye Ah Lee, Sejin Lee, Soyeon Kim, Ye Jun Jung, Chaewon Lee, Hyoeun Kim, Han Ah Lee, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to determine the relationship between sarcopenic obesity (SO) and the risk of significant liver fibrosis or cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD). Through a multicenter retrospective study, it was found that high-risk subjects with SO had a higher risk of liver fibrosis and CVD development. The results demonstrated that high-risk subjects with SO had significantly increased risks of liver fibrosis and CVD development.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Reeju Amatya, Donghee Lee, Kyoung Ah Min, Meong Cheol Shin
Summary: Nonalcoholic fatty liver disease (NAFLD) has become a global epidemic and is the primary cause of chronic liver disease. Without medical intervention, NAFLD can progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. The progression of NAFLD is influenced by genetics, metabolic disorders, and immunologic factors. Fortunately, extensive research has led to the discovery of potent drug candidates, and efforts have been made to improve their druggability. This review provides an overview of clinical trial drug candidates and discusses strategies for developing better drugs.
Article
Oncology
Wojciech Marciniak, Roza Derkacz, Magdalena Muszynska, Piotr Baszuk, Jacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Anna Jakubowska, Michal Falco, Tadeusz Debniak, Marcin Lener, Oleg Oszurek, Katherine Pullella, Joanne Kotsopoulos, Ping Sun, Steven A. Narod, Jan Lubinski
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Urology & Nephrology
Elizabeth C. Page, Elizabeth K. Bancroft, Mark N. Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D. Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, Hans Vasen, Lambertus A. Kiemeney, Janneke Ringelberg, Thomas Dyrso Jensen, Palle J. S. Osther, Brian T. Helfand, Elena Genova, Rogier A. Oldenburg, Cezary Cybulski, Dominika Wokolorczyk, Kai-Ren Ong, Camilla Huber, Jimmy Lam, Louise Taylor, Monica Salinas, Lidia Feliubadalo, Jan C. Oosterwijk, Wendy van Zelst-Stams, Jackie Cook, Derek J. Rosario, Susan Domchek, Jacquelyn Powers, Saundra Buys, Karen O'Toole, Margreet G. E. M. Ausems, Rita K. Schmutzler, Kerstin Rhiem, Louise Izatt, Vishakha Tripathi, Manuel R. Teixeira, Marta Cardoso, William D. Foulkes, Armen Aprikian, Heleen van Randeraad, Rosemarie Davidson, Mark Longmuir, Marielle W. G. Ruijs, Apollonia T. J. M. Helderman van den Enden, Muriel Adank, Rachel Williams, Lesley Andrews, Declan G. Murphy, Dorothy Halliday, Lisa Walker, Annelie Liljegren, Stefan Carlsson, Ashraf Azzabi, Irene Jobson, Catherine Morton, Kylie Shackleton, Katie Snape, Helen Hanson, Marion Harris, Marc Tischkowitz, Amy Taylor, Judy Kirk, Rachel Susman, Rakefet Chen-Shtoyerman, Allan Spigelman, Nicholas Pachter, Munaza Ahmed, Teresa Ramon y Cajal, Janez Zgajnar, Carole Brewer, Neus Gadea, Angela F. Brady, Theo van Os, David Gallagher, Oskar Johannsson, Alan Donaldson, Julian Barwell, Nicola Nicolai, Eitan Friedman, Elias Obeid, Lynn Greenhalgh, Vedang Murthy, Lucia Copakova, Sibel Saya, John McGrath, Peter Cooke, Karina Ronlund, Kate Richardson, Alex Henderson, Soo H. Teo, Banu Arun, Karin Kast, Alexander Dias, Neil K. Aaronson, Audrey Ardern-Jones, Chris H. Bangma, Elena Castro, David Dearnaley, Diana M. Eccles, Karen Tricker, Jorunn Eyfjord, Alison Falconer, Christopher Foster, Henrik Gronberg, Freddie C. Hamdy, Vigdis Stefansdottir, Vincent Khoo, Geoffrey J. Lindeman, Jan Lubinski, Karol Axcrona, Christos Mikropoulos, Anita Mitra, Clare Moynihan, Gadi Rennert, Mohnish Suri, Penny Wilson, Tim Dudderidge, Judith Offman, Zsofia Kote-Jarai, Andrew Vickers, Hans Lilja, Rosalind A. Eeles
Article
Oncology
Jacek Gronwald, Jan Lubinski, Tomasz Huzarski, Cezary Cybulski, Janusz Menkiszak, Monika Siolek, Malgorzata Stawicka, Ping Sun, Shana J. Kim, Joanne Kotsopoulos, Steven A. Narod
GYNECOLOGIC ONCOLOGY
(2019)
Article
Clinical Neurology
Umber Dube, Laura Ibanez, John P. Budde, Bruno A. Benitez, Albert A. Davis, Oscar Harari, Mark M. Iles, Matthew H. Law, Kevin M. Brown, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, M. H. Law, M. H. Law, D. T. Bishop, J. E. Lee, M. Brossard, N. G. Martin, E. K. Moses, F. Song, J. H. Barrett, R. Kumar, D. F. Easton, P. D. Pharoah, A. J. Swerdlow, K. P. Kypreou, J. C. Taylor, M. Harland, J. Randerson-Moor, L. A. Akslen, P. A. Andresen, M. F. Avril, E. Azizi, G. B. Scarra, K. M. Brown, T. Debniak, D. L. Duffy, D. E. Elder, S. Fang, E. Friedman, P. Galan, P. Ghiorzo, E. M. Gillanders, A. M. Goldstein, N. A. Gruis, J. Hansson, P. Helsing, M. Hocevar, V. Hoiom, C. Ingvar, P. A. Kanetsky, W. V. Chen, M. T. Landi, J. Lang, G. M. Lathrop, J. Lubinski, R. M. Mackie, G. J. Mann, A. Molven, G. W. Montgomery, S. Novakovic, H. Olsson, S. Puig, J. A. Puig-Butille, W. Wu, A. A. Qureshi, G. L. Radford-Smith, N. Van der Stoep, R. Van Doorn, D. C. Whiteman, J. E. Craig, E. Schadendorf, L. A. Simms, K. P. Burdon, D. R. Nyholt, K. A. Pooley, N. Orr, A. J. Stratigos, A. E. Cust, S. V. Ward, N. K. Hayward, J. Han, H. J. Schulze, A. M. Dunning, J. A. Bishop, F. Demenais, C. I. Amos, S. MacGregor, M. M. Iles, Carlos Cruchaga
ACTA NEUROPATHOLOGICA
(2020)
Correction
Clinical Neurology
Umber Dube, Laura Ibanez, John P. Budde, Bruno A. Benitez, Albert A. Davis, Oscar Harari, Mark M. Iles, Matthew H. Law, Kevin M. Brown, Carlos Cruchaga
ACTA NEUROPATHOLOGICA
(2020)
Article
Biochemistry & Molecular Biology
Sandra Pietrzak, Janusz Wojcik, Piotr Baszuk, Wojciech Marciniak, Malgorzata Wojtys, Tadeusz Debniak, Cezary Cybulski, Jacek Gronwald, Jacek Alchimowicz, Bartlomiej Masojc, Piotr Waloszczyk, Darko Gajic, Tomasz Grodzki, Anna Jakubowska, Rodney J. Scott, Jan Lubinski, Marcin R. Lener
Summary: This study examined the relationship between blood concentrations of heavy metals and overall survival in lung cancer patients, finding that low blood cadmium levels may be associated with improved overall survival in treated patients with lung cancer.
Article
Biochemistry & Molecular Biology
Jakub Lubinski, Ewa Jaworowska, Roza Derkacz, Wojciech Marciniak, Katarzyna Bialkowska, Piotr Baszuk, Rodney J. Scott, Jan A. Lubinski
Summary: The study revealed that serum zinc levels were correlated with the survival of patients with laryngeal cancer, with higher zinc levels potentially improving survival rates. Additionally, the impact of serum zinc levels on survival was more significant in variants of the antioxidant enzymes SOD2 and CAT.
Article
Biochemistry & Molecular Biology
Emilia Rogoza-Janiszewska, Karolina Malinska, Piotr Baszuk, Wojciech Marciniak, Roza Derkacz, Marcin Lener, Anna Jakubowska, Cezary Cybulski, Tomasz Huzarski, Bartlomiej Masojc, Jacek Gronwald, Helena Rudnicka, Andrzej Kram, Magdalena Kiedrowicz, Magdalena Boer, Tadeusz Debniak, Jan Lubinski
Summary: The study found that patients with low serum selenium levels had a higher mortality rate in the 10 years following melanoma diagnosis compared to patients with high selenium levels. Future studies in regions with low soil selenium levels are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Piotr Baszuk, Paulina Stadnik, Wojciech Marciniak, Roza Derkacz, Anna Jakubowska, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Tadeusz Debniak, Katarzyna Bialkowska, Sandra Pietrzak, Jozef Kladny, Rodney J. Scott, Jan Lubinski, Marcin R. Lener
Summary: The study showed that low blood arsenic levels are significantly associated with increased occurrence of colorectal cancer, and specific gene variants can enhance this correlation. Further validation is needed before definitively stating that the combined effect of low blood arsenic levels with specific gene polymorphisms is a suitable colorectal cancer biomarker.
Article
Oncology
Klaudia Stempa, Dominika Wokolorczyk, Wojciech Kluzniak, Emilia Rogoza-Janiszewska, Karolina Malinska, Helena Rudnicka, Tomasz Huzarski, Jacek Gronwald, Katarzyna Gliniewicz, Tadeusz Debniak, Anna Jakubowska, Marcin Lener, Joanna Tomiczek-Szwiec, Pawel Domagala, Malwina Suszynska, Piotr Kozlowski, Tomasz Kluz, Mariusz Naczk, Jan Lubinski, Steven A. Narod, Mohammad R. Akbari, Cezary Cybulski
Summary: The study found that mutations in the BARD1 gene do not increase the risk of prostate cancer or influence its characteristics or survival. However, BARD1 is a breast cancer predisposition gene, and female relatives of men with BARD1 mutations may benefit from this information.
Article
Oncology
Monika Cieszynska, Wojciech Kluzniak, Dominika Wokolorczyk, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Michal Falco, Tadeusz Debniak, Anna Jakubowska, Roza Derkacz, Wojciech Marciniak, Marcin Lener, Karolina Woronko, Dominika Mocarz, Piotr Baszuk, Marta Bryskiewicz, Steven A. Narod, Jan Lubinski
Summary: This study aimed to evaluate the risk of developing thyroid cancer after a diagnosis of breast cancer and identify therapeutic and genetic risk factors. The findings showed that women carrying a CHEK2 mutation had a higher risk of thyroid cancer.
Article
Biochemistry & Molecular Biology
Piotr Baszuk, Wojciech Marciniak, Roza Derkacz, Anna Jakubowska, Cezary Cybulski, Jacek Gronwald, Tadeusz Debniak, Tomasz Huzarski, Katarzyna Bialkowska, Sandra Pietrzak, Magdalena Muszynska, Jozef Kladny, Steven A. Narod, Jan Lubinski, Marcin R. Lener
Summary: This study found that a high blood copper level is associated with an increased risk of colorectal cancer, especially for early-stage colon cancer, suggesting its potential use as a biomarker in early detection programs.
Article
Nutrition & Dietetics
Magdalena Janowska, Natalia Potocka, Sylwia Paszek, Marzena Skrzypa, Andrzej Wrobel, Marta Kluz, Piotr Baszuk, Wojciech Marciniak, Jacek Gronwald, Jan Lubinski, Izabela Zawlik, Tomasz Kluz
Summary: This study found a correlation between serum selenium levels and an increased risk of endometrial cancer, indicating that patients with low selenium levels should undergo appropriate preventive examinations.
Article
Oncology
Muhammad Usman Rashid, Humaira Naeemi, Noor Muhammad, Asif Loya, Jan Lubinski, Anna Jakubowska, Muhammed Aasim Yusuf
HEREDITARY CANCER IN CLINICAL PRACTICE
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
J. Lubinski
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)