Metal-based nanoparticle interactions with the nervous system: the challenge of brain entry and the risk of retention in the organism

Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia

(2012) Josephine Pinkernelle et al.   BMC NEUROSCIENCE

Cerebrolysin, a Mixture of Neurotrophic Factors Induces Marked Neuroprotection in Spinal Cord Injury Following Intoxication of Engineered Nanoparticles from Metals

(2012) Preeti Kumaran Menon et al.   CNS & Neurological Disorders-Drug Targets

Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial

(2012) Mo Dan et al.   International Journal of Nanomedicine

Effects of copper nanoparticles on rat cerebral microvessel endothelial cells

(2012) William J Trickler et al.   Nanomedicine

Concentration-Dependent, Size-Independent Toxicity of Citrate Capped AuNPs in Drosophila melanogaster

(2012) Giuseppe Vecchio et al.   PLoS One

Distribution, Elimination, and Biopersistence to 90 Days of a Systemically Introduced 30 nm Ceria-Engineered Nanomaterial in Rats

(2012) Robert A. Yokel et al.   TOXICOLOGICAL SCIENCES

Effects of Silver Nanoparticles on Primary Mixed Neural Cell Cultures: Uptake, Oxidative Stress and Acute Calcium Responses

(2012) Andrea Haase et al.   TOXICOLOGICAL SCIENCES

The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats

(2012) Ye Liu et al.   TOXICOLOGY LETTERS

Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy

(2012) Mamta Wankhede et al.   Expert Review of Clinical Pharmacology

Target-Specific Gene Silencing of Layer-by-Layer Assembled Gold–Cysteamine/siRNA/PEI/HA Nanocomplex

(2011) Min-Young Lee et al.   ACS Nano

In vitro evidence of dysregulation of blood–brain barrier function after acute and repeated/long-term exposure to TiO2 nanoparticles

(2011) Emilie Brun et al.   BIOMATERIALS

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity

(2011) Christopher J. Rivet et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Gene expression of zebrafish embryos exposed to titanium dioxide nanoparticles and hydroxylated fullerenes

(2011) Boris Jovanović et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Nano-CeO2Exhibits Adverse Effects at Environmental Relevant Concentrations

(2011) Haifeng Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

(2011) Stephanie Hirn et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Isotherm modeling of organic activated bentonite and humic acid polymer used as mycotoxin adsorbents

(2011) R.R. Santos et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Nervous system effects in rats on subacute exposure by lead-containing nanoparticles via the airways

(2011) Gábor Oszlánczi et al.   INHALATION TOXICOLOGY

Nanotechnology and Nanotoxicology in Retinopathy

(2011) Dong Hyun Jo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydrophilic/hydrophobic features of TiO2 nanoparticles as a function of crystal phase, surface area and coating, in relation to their potential toxicity in peripheral nervous system

(2011) V. Bolis et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Gold Revolution—Gold Nanoparticles for Modern Medicine and Surgery

(2011) Radoslaw A. Rippel et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phospholipid Membrane Encapsulation of Nanoparticles for Surface-Enhanced Raman Scattering

(2011) Shell Ip et al.   LANGMUIR

Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio)

(2011) Te-Hao Chen et al.   MARINE POLLUTION BULLETIN

Human amniotic membrane-derived mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles: the effect on neuron-like differentiation in vitro

(2011) Guangwei Zeng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Gold nanorod–siRNA induces efficientin vivogene silencing in the rat hippocampus

(2011) Adela C Bonoiu et al.   Nanomedicine

Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature

(2011) Arnold B. Etame et al.   Nanomedicine-Nanotechnology Biology and Medicine

Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor

(2011) P. P. Pompa et al.   Nanoscale

Uptake of dimercaptosuccinate-coated magnetic iron oxide nanoparticles by cultured brain astrocytes

(2011) Mark Geppert et al.   NANOTECHNOLOGY

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation

(2011) Xinghua Shi et al.   Nature Nanotechnology

Subchronic inhalation toxicity of gold nanoparticles

(2011) Jae Sung et al.   Particle and Fibre Toxicology

Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies

(2011) Humphrey H. P. Yiu et al.   PHARMACEUTICAL RESEARCH

Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

(2011) Yu Cheng et al.   Small

Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines

(2011) Tiago dos Santos et al.   Small

Tumor Targeting and Imaging Using Cyclic RGD-PEGylated Gold Nanoparticle Probes with Directly Conjugated Iodine-125

(2011) Young-Hwa Kim et al.   Small

Multicompartment and multigeometry nanoparticle assembly

(2011) Darrin J. Pochan et al.   Soft Matter

The effect of titanium dioxide on the biochemical constituents of the brain of Zebrafish (Danio rerio): An FT-IR study

(2011) PL.RM. Palaniappan et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure

(2011) Yun Wang et al.   TOXICOLOGY LETTERS

Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors

(2011) Hari Shanker Sharma et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease

(2011) Stephen C. Bondy   International Journal of Environmental Research and Public Health

In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis

(2011) Aracely Rocha et al.   JOURNAL OF NANOBIOTECHNOLOGY

Microglial Response to Gold Nanoparticles

(2010) Eliza Hutter et al.   ACS Nano

Accurate localization of a fall in pH within the ileocecal region: validation using a dual-scintigraphic technique

(2010) Natalia Zarate et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure

(2010) Jinyuan Chen et al.   AQUATIC TOXICOLOGY

Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice

(2010) C. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytotoxic effects of surface-modified quantum dots on neuron-like PC12 cells cultured inside microfluidic devices

(2010) Sanjeev Kumar Mahto et al.   BioChip Journal

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

(2010) Renping Hu et al.   BIOMATERIALS

Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling

(2010) Stefaan J.H. Soenen et al.   BIOMATERIALS

EGFRvIII Antibody-Conjugated Iron Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery and Targeted Therapy of Glioblastoma

(2010) C. G. Hadjipanayis et al.   CANCER RESEARCH

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

(2010) Nikolai Khlebtsov et al.   CHEMICAL SOCIETY REVIEWS

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Long-circulating Targeted Nanoparticles for Cancer Therapy

(2010) Yang Liu et al.   Current Nanoscience

Induction of Inflammatory Responses in Mice Treated with Cerium Oxide Nanoparticles by Intratracheal Instillation

(2010) Eun-Jung Park et al.   JOURNAL OF HEALTH SCIENCE

Silver Nanoparticles Crossing Through and Distribution in the Blood-Brain Barrier In Vitro

(2010) Jinglong Tang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme

(2010) Klaus Maier-Hauff et al.   JOURNAL OF NEURO-ONCOLOGY

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipopolysaccharide-QD Micelles Induce Marked Induction of TLR2 and Lipid Droplet Accumulation in Olfactory Bulb Microglia

(2010) Mélanie Lalancette-Hébert et al.   MOLECULAR PHARMACEUTICS

Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

(2010) Julia V Georgieva et al.   MOLECULAR THERAPY

Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles

(2010) Raquel Mejías et al.   Nanomedicine

Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide

(2010) Simon Guerrero et al.   Nanomedicine

Cytotoxicity of sophorolipid-gellan gum-gold nanoparticle conjugates and their doxorubicin loaded derivatives towards human glioma and human glioma stem cell lines

(2010) Sheetal Dhar et al.   Nanoscale

Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain

(2010) Shingo Kato et al.   NANOTECHNOLOGY

Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles

(2010) Yu-Shiun Chen et al.   NANOTECHNOLOGY

Toxicity of gold-nanoparticles: Synergistic effects of shape and surface functionalization on micromotility of epithelial cells

(2010) Marco Tarantola et al.   Nanotoxicology

Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability

(2010) William J. Trickler et al.   Nanotoxicology

Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

(2010) H.-L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality

(2010) Stefaan J. H. Soenen et al.   Small

Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria

(2010) Sarita S. Hardas et al.   TOXICOLOGICAL SCIENCES

Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells

(2010) William J. Trickler et al.   TOXICOLOGICAL SCIENCES

Size-dependent tissue kinetics of PEG-coated gold nanoparticles

(2010) Wan-Seob Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interaction of Gold Nanoparticles with Common Human Blood Proteins

(2009) Silvia H. De Paoli Lacerda et al.   ACS Nano

Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity

(2009) Linglan Ma et al.   BIOMATERIALS

Anti-proliferative activity of silver nanoparticles

(2009) PV AshaRani et al.   BMC CELL BIOLOGY

Ag nanoparticles sensitize IR-induced killing of cancer cells

(2009) Ruizhi Xu et al.   CELL RESEARCH

Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells

(2009) Masanori Horie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability

(2009) Ewa Przybytkowski et al.   FEBS Journal

Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region

(2009) Guilherme J. M. Garcia et al.   INHALATION TOXICOLOGY

Subretinal delivery of immunoglobulin G with gold nanoparticles in the rabbit eye

(2009) Atsushi Hayashi et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery

(2009) Georgy S. Terentyuk et al.   Journal of Biophotonics

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems

(2009) Ken Takeda et al.   JOURNAL OF HEALTH SCIENCE

Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes

(2009) Hua-Jie Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Genomics-based screening of differentially expressed genes in the brains of mice exposed to silver nanoparticles via inhalation

(2009) Hye-Young Lee et al.   JOURNAL OF NANOPARTICLE RESEARCH

Chronic Treatment with Nanoparticles Exacerbate Hyperthermia Induced Blood-Brain Barrier Breakdown, Cognitive Dysfunction and Brain Pathology in the Rat. Neuroprotective Effects of Nanowired-Antioxidant Compound H-290/51

(2009) Hari Shanker Sharma et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Influence of Engineered Nanoparticles from Metals on the Blood-Brain Barrier Permeability, Cerebral Blood Flow, Brain Edema and Neurotoxicity. An Experimental Study in the Rat and Mice Using Biochemical and Morphological Approaches

(2009) Hari S. Sharma et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels

(2009) P. S. Tsai et al.   JOURNAL OF NEUROSCIENCE

Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

(2009) Lourdes Garza-Ocañas et al.   Metallomics

Probing and preventing quantum dot-induced cytotoxicity with multimodal α-lipoic acid in multiple dimensions of the peripheral nervous system

(2009) Manasi P Jain et al.   Nanomedicine

Assessment of the In Vivo Toxicity of Gold Nanoparticles

(2009) Yu-Shiun Chen et al.   Nanoscale Research Letters

Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved Biocompatibility

(2009) Santaneel Ghosh et al.   Nanoscale Research Letters

The chemical fate of the Cd/Se/Te-based quantum dot 705 in the biological system: toxicity implications

(2009) Chia-Hua Lin et al.   NANOTECHNOLOGY

Differential plasma protein binding to metal oxide nanoparticles

(2009) Zhou J Deng et al.   NANOTECHNOLOGY

Nanosized zinc oxide particles induce neural stem cell apoptosis

(2009) Xiaoyong Deng et al.   NANOTECHNOLOGY

Intravenously administered gold nanoparticles pass through the blood–retinal barrier depending on the particle size, and induce no retinal toxicity

(2009) Jeong Hun Kim et al.   NANOTECHNOLOGY

Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial

(2009) Robert A. Yokel et al.   Nanotoxicology

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Nanoparticles can cause DNA damage across a cellular barrier

(2009) Gevdeep Bhabra et al.   Nature Nanotechnology

Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective

(2009) Mélanie Auffan et al.   Nature Nanotechnology

Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse

(2009) J.A. Shin et al.   NEUROSCIENCE

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

(2009) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

(2009) Wan-Seob Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Quantum Dots Bearing Lectin-Functionalized Nanoparticles as a Platform forIn VivoBrain Imaging

(2008) Xiaoling Gao et al.   BIOCONJUGATE CHEMISTRY

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

(2008) Wim H. De Jong et al.   BIOMATERIALS

Biological applications of gold nanoparticles

(2008) Ralph A. Sperling et al.   CHEMICAL SOCIETY REVIEWS

Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size

(2008) Ganeshchandra Sonavane et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Unmodified CdSe Quantum Dots Induce Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons

(2008) Mingliang Tang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Partial Oxidation (“Aging”) and Surface Modification Decrease the Toxicity of Nanosized Zerovalent Iron

(2008) Tanapon Phenrat et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice

(2008) Bing Wang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Manufactured Aluminum Oxide Nanoparticles Decrease Expression of Tight Junction Proteins in Brain Vasculature

(2008) Lei Chen et al.   Journal of Neuroimmune Pharmacology

Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots

(2008) Hamid Daneshvar et al.   Nanomedicine

Toxicity of silver nanoparticles in zebrafish models

(2008) P V Asharani et al.   NANOTECHNOLOGY

Sciatic nerve repair by microgrooved nerve conduits made of chitosan-gold nanocomposites

(2008) Yi-Lo Lin et al.   SURGICAL NEUROLOGY

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS

Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots

(2008) Jim E. Riviere   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Colloidal metallic gold is not bio-inert

(2008) C. L. Brown et al.   INFLAMMOPHARMACOLOGY