Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents

Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting

(2012) Lin Zhu et al.   ACS Nano

Cell-penetrating peptides for the delivery of nucleic acids

(2012) Taavi Lehto et al.   Expert Opinion on Drug Delivery

Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

(2012) Helerin Margus et al.   MOLECULAR THERAPY

Digital Switching of Local Arginine Density in a Genetically Encoded Self-Assembled Polypeptide Nanoparticle Controls Cellular Uptake

(2012) Sarah R. MacEwan et al.   NANO LETTERS

Peptides for cell-selective drug delivery

(2012) Nina Svensen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cellular Uptake and Fate of PEGylated Gold Nanoparticles Is Dependent on Both Cell-Penetration Peptides and Particle Size

(2011) Eunkeu Oh et al.   ACS Nano

Self-Activation in De Novo Designed Mimics of Cell-Penetrating Peptides

(2011) Abhigyan Som et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Protein Target Detection by Quantum Dots Optimized for Live Cell Imaging

(2011) Youngseon Choi et al.   BIOCONJUGATE CHEMISTRY

Design of Acid-Activated Cell Penetrating Peptide for Delivery of Active Molecules into Cancer Cells

(2011) Wei Zhang et al.   BIOCONJUGATE CHEMISTRY

Distribution of KAI-9803, a Novel  -Protein Kinase C Inhibitor, after Intravenous Administration to Rats

(2011) Y. Miyaji et al.   DRUG METABOLISM AND DISPOSITION

Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals

(2011) Yao Qin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inverted micelle formation of cell-penetrating peptide studied by coarse-grained simulation: Importance of attractive force between cell-penetrating peptides and lipid head group

(2011) Shuhei Kawamoto et al.   JOURNAL OF CHEMICAL PHYSICS

Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity

(2011) Erez Koren et al.   JOURNAL OF CONTROLLED RELEASE

Tumor Targeting of MMP-2/9 Activatable Cell-Penetrating Imaging Probes Is Caused by Tumor-Independent Activation

(2011) S. M. J. van Duijnhoven et al.   JOURNAL OF NUCLEAR MEDICINE

Spontaneous Membrane-Translocating Peptides by Orthogonal High-Throughput Screening

(2011) Jessica R. Marks et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Delivery of Cargoes into a Murine Solid Tumor by a Cell-Penetrating Peptide and Cleavable Poly(ethylene glycol) Comodified Liposomal Delivery System via Systemic Administration

(2011) Rui Kuai et al.   MOLECULAR PHARMACEUTICS

Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration

(2011) Takanori Kanazawa et al.   PHARMACEUTICAL RESEARCH

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

siRNA Delivery to CNS Cells using a Membrane Translocation Peptide

(2010) Marytheresa A. Ifediba et al.   BIOCONJUGATE CHEMISTRY

Noncationic Dipeptide Mimic Oligomers As Cell Penetrating Nonpeptides (CPNP)

(2010) Lubomir L. Vezenkov et al.   BIOCONJUGATE CHEMISTRY

Protease-Activatable Organometal−Peptide Bioconjugates with Enhanced Cytotoxicity on Cancer Cells

(2010) Katrin Splith et al.   BIOCONJUGATE CHEMISTRY

Light induced drug delivery into cancer cells

(2010) Yosi Shamay et al.   BIOMATERIALS

Characterization of Bioactive Cell Penetrating Peptides from Human Cytochrome c: Protein Mimicry and the Development of a Novel Apoptogenic Agent

(2010) Sarah Jones et al.   CHEMISTRY & BIOLOGY

ATTEMPTS System: A Macromolecular Prodrug Strategy for Cancer Drug Delivery

(2010) Yongzhuo Huang et al.   CURRENT PHARMACEUTICAL DESIGN

Efficacy and Safety Evaluation of a Novel Botulinum Toxin Topical Gel for the Treatment of Moderate to Severe Lateral Canthal Lines

(2010) FREDRIC BRANDT et al.   DERMATOLOGIC SURGERY

Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting

(2010) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Internalization and Intracellular Trafficking of a PTD-Conjugated Anti-Fibrotic Peptide, AZX100, in Human Dermal Keloid Fibroblasts

(2010) Charles R. Flynn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Design, Synthesis, and Imaging of an Activatable Photoacoustic Probe

(2010) Jelena Levi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Delivery of Payload into Tumor Cells in a Controlled Manner by TAT and Thiolytic Cleavable PEG Co-Modified Liposomes

(2010) Rui Kuai et al.   MOLECULAR PHARMACEUTICS

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

(2010) Q. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

(2009) Emilia S. Olson et al.   Integrative Biology

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

(2009) Todd A. Aguilera et al.   Integrative Biology

Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo

(2009) Rupa R. Sawant et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

(2009) Roopali Roy et al.   JOURNAL OF CLINICAL ONCOLOGY

The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats

(2009) J-R. Liu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

(2008) Judith Mueller et al.   BIOCONJUGATE CHEMISTRY

Development of an optimized activatable MMP-14 targeted SPECT imaging probe

(2008) Gregory A. Watkins et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

(2008) Kazuya Taniguchi et al.   CANCER SCIENCE

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

(2008) Vladimir Torchilin   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking

(2008) Ikramy A. Khalil et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preliminaryin vivoevaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy

(2008) Yong Tao Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

PTD-modified ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation

(2008) Y KWON et al.   JOURNAL OF CONTROLLED RELEASE

Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance

(2008) Eun Seong Lee et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated and MMP-2 Specifically DePEGylated Quantum Dots: Comparative Evaluation of Cellular Uptake

(2008) Hyejung Mok et al.   LANGMUIR

Protease-Triggered Unveiling of Bioactive Nanoparticles

(2008) Todd J. Harris et al.   Small

Temperature Triggered Self-Assembly of Polypeptides into Multivalent Spherical Micelles

(2007) Matthew R. Dreher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY