Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

(2015) Hidehisa Takahashi et al.   Nature Communications

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

Redefining the modular organization of the core Mediator complex

(2014) Xuejuan Wang et al.   CELL RESEARCH

The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions

(2014) C. S. Gillmor et al.   DEVELOPMENT

Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant

(2014) Nicholas D. Bonawitz et al.   NATURE

Mediator subunit 16 functions in the regulation of iron uptake gene expression in Arabidopsis

(2014) Yue Zhang et al.   NEW PHYTOLOGIST

CYCLIN-DEPENDENT KINASE8 Differentially Regulates Plant Immunity to Fungal Pathogens through Kinase-Dependent and -Independent Functions in Arabidopsis

(2014) Y. Zhu et al.   PLANT CELL

The Arabidopsis Mediator Complex Subunits MED16, MED14, and MED2 Regulate Mediator and RNA Polymerase II Recruitment to CBF-Responsive Cold-Regulated Genes

(2014) P. A. Hemsley et al.   PLANT CELL

SAD1, an RNA polymerase I subunit A34.5 of rice, interacts with Mediator and controls various aspects of plant development

(2014) Weiqiang Li et al.   PLANT JOURNAL

The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25

(2014) Yan Yang et al.   PLANT JOURNAL

PHYTOCHROME AND FLOWERING TIME1/MEDIATOR25 Regulates Lateral Root Formation via Auxin Signaling in Arabidopsis

(2014) J. Raya-Gonzalez et al.   PLANT PHYSIOLOGY

MED18 interaction with distinct transcription factors regulates multiple plant functions

(2014) Zhibing Lai et al.   Nature Communications

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

The Mediator complex and transcription regulation

(2013) Zachary C. Poss et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Differential Regulation of White-Opaque Switching by Individual Subunits of Candida albicans Mediator

(2013) Anda Zhang et al.   EUKARYOTIC CELL

Srb5/Med18-mediated Termination of Transcription Is Dependent on Gene Looping

(2013) Banupriya Mukundan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes

(2013) Taiki Tsutsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis

(2013) Jitendra Kumar Thakur et al.   MOLECULAR GENETICS AND GENOMICS

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses

(2013) Xudong Zhang et al.   PLANT JOURNAL

Mediator Subunit18 Controls Flowering Time and Floral Organ Identity in Arabidopsis

(2013) Zhengui Zheng et al.   PLoS One

Mediator Directs Co-transcriptional Heterochromatin Assembly by RNA Interference-Dependent and -Independent Pathways

(2013) Eriko Oya et al.   PLoS Genetics

The Mediator complex and transcription elongation

(2012) Ronald C. Conaway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes

(2012) R. Fukasawa et al.   JOURNAL OF BIOCHEMISTRY

Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit

(2012) Yan Huang et al.   MOLECULAR CELL

Transcriptional Regulation by Pol II(G) Involving Mediator and Competitive Interactions of Gdown1 and TFIIF with Pol II

(2012) Miki Jishage et al.   MOLECULAR CELL

Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes

(2012) Bo Cheng et al.   MOLECULAR CELL

The Mediator subunit SFR6/MED16 controls defence gene expression mediated by salicylic acid and jasmonate responsive pathways

(2012) Deepthi L. Wathugala et al.   NEW PHYTOLOGIST

PFT1, a transcriptional Mediator complex subunit, controls root hair differentiation through reactive oxygen species (ROS) distribution in Arabidopsis

(2012) Kalaipandian Sundaravelpandian et al.   NEW PHYTOLOGIST

CRYPTIC PRECOCIOUS/MED12 is a Novel Flowering Regulator with Multiple Target Steps in Arabidopsis

(2012) Yuri Imura et al.   PLANT AND CELL PHYSIOLOGY

Non-Recognition-of-BTH4, anArabidopsisMediator Subunit Homolog, Is Necessary for Development and Response to Salicylic Acid

(2012) Juan Vicente Canet et al.   PLANT CELL

The Arabidopsis Mediator Subunit MED25 Differentially Regulates Jasmonate and Abscisic Acid Signaling through Interacting with the MYC2 and ABI5 Transcription Factors

(2012) R. Chen et al.   PLANT CELL

TheArabidopsisMediator Complex Subunit16 Positively Regulates Salicylate-Mediated Systemic Acquired Resistance and Jasmonate/Ethylene-Induced Defense Pathways

(2012) Xudong Zhang et al.   PLANT CELL

Proteasome-Mediated Turnover of Arabidopsis MED25 Is Coupled to the Activation of FLOWERING LOCUS T Transcription

(2012) S. Inigo et al.   PLANT PHYSIOLOGY

MEDIATOR25 Acts as an Integrative Hub for the Regulation of Jasmonate-Responsive Gene Expression in Arabidopsis

(2012) V. Cevik et al.   PLANT PHYSIOLOGY

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

(2012) Zhongle Liu et al.   PLoS One

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

Function and regulation of the Mediator complex

(2011) Ronald C Conaway et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana

(2011) R. Xu et al.   DEVELOPMENT

The role of Mediator in small and long noncoding RNA production inArabidopsis thaliana

(2011) Yun Ju Kim et al.   EMBO JOURNAL

Novel Role for Mediator Complex Subunit Srb5/Med18 in Termination of Transcription

(2011) Banupriya Mukundan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REF4 and RFR1, Subunits of the Transcriptional Coregulatory Complex Mediator, Are Required for Phenylpropanoid Homeostasis inArabidopsis

(2011) Nicholas D. Bonawitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OsSFR6 is a functional rice orthologue of SENSITIVE TO FREEZING-6 and can act as a regulator of COR gene expression, osmotic stress and freezing tolerance in Arabidopsis

(2011) Deepthi L. Wathugala et al.   NEW PHYTOLOGIST

Histone modifications influence mediator interactions with chromatin

(2011) Xuefeng Zhu et al.   NUCLEIC ACIDS RESEARCH

MACCHI-BOU 2 is Required for Early Embryo Patterning and Cotyledon Organogenesis in Arabidopsis

(2011) Jun Ito et al.   PLANT AND CELL PHYSIOLOGY

PFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis

(2011) Sabrina Iñigo et al.   PLANT JOURNAL

The Mediator Complex in Plants: Structure, Phylogeny, and Expression Profiling of Representative Genes in a Dicot (Arabidopsis) and a Monocot (Rice) during Reproduction and Abiotic Stress

(2011) S. Mathur et al.   PLANT PHYSIOLOGY

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development

(2011) N. Elfving et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse roles of the Mediator complex in plants

(2011) Brendan N. Kidd et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of the floral repressor gene FLC: the complexity of transcription in a chromatin context

(2010) Pedro Crevillén et al.   CURRENT OPINION IN PLANT BIOLOGY

Long non-coding RNAs and chromatin regulation

(2010) Filomena De Lucia et al.   CURRENT OPINION IN PLANT BIOLOGY

Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation

(2010) M. Belakavadi et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana

(2010) D. Maruyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human Mediator complex: a versatile, genome-wide regulator of transcription

(2010) Dylan J. Taatjes   TRENDS IN BIOCHEMICAL SCIENCES

Arabidopsis thaliana PRP40s are RNA polymerase II C-terminal domain-associating proteins

(2009) Chang Ho Kang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis

(2009) C. S. Gillmor et al.   DEVELOPMENT

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

(2009) M. T. Knuesel et al.   GENES & DEVELOPMENT

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models

(2009) Alejandro Leal et al.   NEUROGENETICS

HISTONE MONOUBIQUITINATION1 Interacts with a Subunit of the Mediator Complex and Regulates Defense against Necrotrophic Fungal Pathogens in Arabidopsis

(2009) R. Dhawan et al.   PLANT CELL

The Mediator Complex Subunit PFT1 Is a Key Regulator of Jasmonate-Dependent Defense in Arabidopsis

(2009) B. N. Kidd et al.   PLANT CELL

Mediator complex association with constitutively transcribed genes in yeast

(2009) S. A. Ansari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana

(2008) Y. Li et al.   GENES & DEVELOPMENT

Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p

(2008) Jitendra K. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Root Elongation by Histone Acetylation in Arabidopsis

(2008) Alexander Krichevsky et al.   JOURNAL OF MOLECULAR BIOLOGY

MyoD Targets TAF3/TRF3 to Activate Myogenin Transcription

(2008) Maria Divina E. Deato et al.   MOLECULAR CELL

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

(2008) Ning Ding et al.   MOLECULAR CELL

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH

Multiple Mechanism-Mediated Retention of a Defective Brassinosteroid Receptor in the Endoplasmic Reticulum of Arabidopsis

(2008) Z. Hong et al.   PLANT CELL

AtRECQ2, a RecQ-helicase homologue from Arabidopsis thaliana, is able to disrupt different recombinogenic DNA-structures in vitro

(2008) Daniela Kobbe et al.   PLANT JOURNAL

Identification of SFR6, a key component in cold acclimation acting post-translationally on CBF function

(2008) Heather Knight et al.   PLANT JOURNAL

SENSITIVE TO FREEZING6 Integrates Cellular and Environmental Inputs to the Plant Circadian Clock

(2008) H. Knight et al.   PLANT PHYSIOLOGY