Stable heterologous expression of biologically active terpenoids in green plant cells

The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.

(2015) Ke Yang et al.   PLANT MOLECULAR BIOLOGY

Microbial Synthesis of the Forskolin Precursor Manoyl Oxide in an Enantiomerically Pure Form

(2014) Morten T. Nielsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced biosynthesis of bioactive abietane diterpenes by overexpressing AtDXS or AtDXR genes in Salvia sclarea hairy roots

(2014) Mariacarmela Vaccaro et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Comparison of plant-based expression platforms for the heterologous production of geraniol

(2014) Nikolay Vasilev et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Manoyl Oxide (13R), the Biosynthetic Precursor of Forskolin, Is Synthesized in Specialized Root Cork Cells in Coleus forskohlii

(2014) I. Pateraki et al.   PLANT PHYSIOLOGY

Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene

(2014) Xin Zhan et al.   Frontiers in Plant Science

Transcriptome Analysis of Thapsia laciniata Rouy Provides Insights into Terpenoid Biosynthesis and Diversity in Apiaceae

(2013) Damian Drew et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

Plant P450s as versatile drivers for evolution of species-specific chemical diversity

(2013) B. Hamberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes

(2013) Corinna Weitzel et al.   PHYTOCHEMISTRY REVIEWS

Genetically engineered maize plants reveal distinct costs and benefits of constitutive volatile emissions in the field

(2013) Christelle Aurélie Maud Robert et al.   PLANT BIOTECHNOLOGY JOURNAL

A 7-Deoxyloganetic Acid Glucosyltransferase Contributes a Key Step in Secologanin Biosynthesis in Madagascar Periwinkle

(2013) K. Asada et al.   PLANT CELL

High-level diterpene production by transient expression in Nicotiana benthamiana

(2013) Kathleen Brückner et al.   Plant Methods

Enzyme Inhibitor Studies Reveal Complex Control of Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzyme Expression in Catharanthus roseus

(2013) Mei Han et al.   PLoS One

Biosynthesis of Sandalwood Oil: Santalum album CYP76F Cytochromes P450 Produce Santalols and Bergamotol

(2013) Maria L. Diaz-Chavez et al.   PLoS One

Identification and characterization of a kunzeaol synthase fromThapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin

(2012) Benjamin Pickel et al.   BIOCHEMICAL JOURNAL

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes-current status and future opportunities

(2012) B. Markus Lange et al.   PLANT BIOTECHNOLOGY JOURNAL

Rational Diversification of a Promoter Providing Fine-Tuned Expression and Orthogonal Regulation for Synthetic Biology

(2012) Benjamin A. Blount et al.   PLoS One

Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species

(2012) Elsa Góngora-Castillo et al.   PLoS One

Overexpressing 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGR) in the Lactococcal Mevalonate Pathway for Heterologous Plant Sesquiterpene Production

(2012) Adelene Ai-Lian Song et al.   PLoS One

RNAi-mediated disruption of squalene synthase improves drought tolerance and yield in rice

(2011) Lakshmi P. Manavalan et al.   JOURNAL OF EXPERIMENTAL BOTANY

Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures

(2011) Guoyin Kai et al.   METABOLIC ENGINEERING

Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance

(2011) Hui Wang et al.   PLANT BIOTECHNOLOGY JOURNAL

Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae

(2011) Martin Lohr et al.   PLANT SCIENCE

Biotechnology in plant essential oil production: progress and perspective in metabolic engineering of the terpene pathway

(2010) L. Daviet et al.   FLAVOUR AND FRAGRANCE JOURNAL

Golden Rice and ‘Golden’ crops for human nutrition

(2010) Peter Beyer   New Biotechnology

Production of biologically active recombinant human factor H in Physcomitrella

(2010) Annette Büttner-Mainik et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of artemisinin precursors in tobacco

(2010) Yansheng Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

(2010) Teun W. J. M. van Herpen et al.   PLoS One

Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

(2009) E. Cordoba et al.   JOURNAL OF EXPERIMENTAL BOTANY

Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis

(2009) Damian Paul Drew et al.   PHYTOCHEMISTRY REVIEWS

A Novel Pathway for Sesquiterpene Biosynthesis from Z,Z-Farnesyl Pyrophosphate in the Wild Tomato Solanum habrochaites

(2009) C. Sallaud et al.   PLANT CELL

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

(2009) Aldwin Anterola et al.   TRANSGENIC RESEARCH

Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols

(2008) Chikara Ohto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

(2008) Shuiqin Wu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Incorporating genome-wide DNA sequence information into a dynamic whole-cell model of Escherichia coli: application to DNA replication

(2008) J.C. Atlas et al.   IET Systems Biology

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways

(2008) Benjamín Nieto et al.   PHYTOCHEMISTRY

Genetic Evidence for the Role of Isopentenyl Diphosphate Isomerases in the Mevalonate Pathway and Plant Development in Arabidopsis

(2008) Kazunori Okada et al.   PLANT AND CELL PHYSIOLOGY

Biochemical and Genomic Characterization of Terpene Synthases in Magnolia grandiflora

(2008) S. Lee et al.   PLANT PHYSIOLOGY