Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
Article
Microbiology
Marilena P. Etna, Aurora Signorazzi, Daniela Ricci, Martina Severa, Fabiana Rizzo, Elena Giacomini, Andrea Gaggioli, Isabelle Bekeredjian-Ding, Anke Huckriede, Eliana M. Coccia
Summary: The study showed that inactivated TBEV (I-TBEV) induced differentiation of a sub-population of plasmacytoid dendritic cells (pDC) specialized in type I interferon production in human PBMC. This was critical for B cell differentiation to plasmablasts, highlighting the importance of preserving key viral molecules during vaccine manufacturing process.
Editorial Material
Immunology
Amy L. Kenter, Justin M. Richner
Summary: Animal studies and explant cultures of human lymphoid tissues are not reliable models of human vaccine responses. Reassociating human tonsillar cells in ex vivo culture leads to organoid formation, providing an exciting new tool to investigate human humoral immune responses to infection.
TRENDS IN IMMUNOLOGY
(2021)
Review
Oncology
Xavier Roussel, Francine Garnache Ottou, Florian Renosi
Summary: Plasmacytoid dendritic cells (pDC) are the main type I interferon-producing cells in humans and are capable of regulating innate and adaptive immune responses. Tumor infiltration by pDC is well-documented in various cancers and is associated with unfavorable clinical outcomes. While Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN) is a well-described aggressive leukemia derived from pDCs, the understanding of tumor infiltration by mature pDCs in Myeloid Neoplasms (MN) is limited. This review aims to provide a comprehensive overview of pDC biology in MN, emphasizing the need for further research into pDC oncogenesis and immune responses for better therapeutic strategies.
Article
Endocrinology & Metabolism
Amrit Raj Ghosh, Purbita Bandopadhyay, Jit Sarkar, Shashi Khanna, Tamonas Chaudhuri, Om Tantia, Partha Chakrabarti, Dipyaman Ganguly
Summary: Mitochondrial DNA complexed with transcription factor A protein acts as interferogenic ligands for plasmacytoid dendritic cells in visceral adipose tissue of obese individuals. Moreover, obesity induces autoreactivity against TFAM as an autoantigen.
Article
Immunology
Laura C. Van Eyndhoven, Eleni Chouri, Nikita Subedi, Jurjen Tel
Summary: Plasmacytoid dendritic cells (pDCs) are a rare type of immune cells with specialized functions in producing large amounts of type I interferon (IFN-I) and exerting cytotoxic effects. Studies show that only a small percentage of pDCs respond to activation by toll-like receptors with IFN alpha secretion and upregulation of cytotoxic markers. The early IFN-producing pDCs, known as first responders, exhibit high expression of PD-L1 and TRAIL, while IFN-I primed cells increase IFN alpha production but do not significantly enhance cytotoxicity. Through droplet-based microfluidics, researchers observed that first responders play a key role in orchestrating population-wide IFN-I responses and have a high cytotoxic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Anna-Lena Muller, Christian Casar, Max Preti, Daria Krzikalla, Cornelia Gottwick, Pia Averhoff, Philip Rosenstiel, Mathias Gelderblom, Marcus Altfeld, Ansgar W. Lohse, Silja Steinmann, Marcial Sebode, Jenny Krause, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel
Summary: The study reveals the crucial role of type 2 conventional dendritic cells in orchestrating the inflammatory immune response to bile duct injury in PSC, suggesting them as potential therapeutic targets for PSC treatment.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, Marcello Chieppa
Summary: Dendritic cells can be divided into myeloid dendritic cells and plasmacytoid dendritic cells, which play important roles in regulating immune responses. Inflammatory bowel diseases are characterized by leaky intestinal barrier and translocation of bacterial lipopolysaccharide. It was found that quercetin can modulate dendritic cell responses through a specific molecular pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kevin Lenogue, Alexandre Walencik, Karine Laulagnier, Jean-Paul Molens, Houssem Benlalam, Brigitte Dreno, Pierre Coulie, Martin Pule, Laurence Chaperot, Joel Plumas
Summary: The study improved a plasmacytoid dendritic cell line platform through retroviral engineering, demonstrating efficient processing and presentation of transduced antigens and expansion of specific cytotoxic effectors through polyepitope constructs. Furthermore, the addition of LAMP-1 sequence enhanced the presentation of certain peptides, and the transduction of new HLA molecules allowed the platform to benefit multiple patients.
Article
Immunology
David M. Koelle, Lichun Dong, Lichen Jing, Kerry J. Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M. Posavad
Summary: HSV-2-specific T-RM cells are abundant in the female reproductive tract between episodes of recurrent genital herpes, provide protection, and maintain the ability to expand.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Florian Renosi, Mary Callanan, Christine Lefebvre
Summary: This review discusses the differential diagnosis between Blastic pDC Neoplasm (BPDCN) and Acute Myeloid Leukemia with pDC expansion (pDC-AML) and their genomic features. Understanding the distinct characteristics of these two diseases is crucial for diagnosis and treatment.
Article
Virology
Jonas L. Delva, Cliff Van Waesberghe, Wim Van den Broeck, Jochen A. Lamote, Nick Vereecke, Sebastiaan Theuns, Liesbeth Couck, Herman W. Favoreel
Summary: The PRV vaccine strain Bartha plays a critical role in eradicating the disease in many countries, but its interaction with host cells and the immune system remains poorly understood. Bartha-infected epithelial cells produce increased amounts of infectious virus, leading to pDC hyperactivation. This phenotype is caused by the deletion of genes encoding US2 and gE/gI.
JOURNAL OF VIROLOGY
(2022)
Editorial Material
Hematology
Haroon Shaikh, Andreas Beilhack
Summary: In this study, Zhu et al1 have identified vasoactive intestinal peptide (VIP) expression on plasmacytoid dendritic cells (pDCs) as an important mechanism that regulates the alloreactivity of allogeneic T cells and mitigates the severity of acute graft-versus-host disease (aGVHD).
Editorial Material
Hematology
Taisuke Kanaji
Summary: The research reveals a novel surveillance mechanism where plasmacytoid dendritic cell-like cells regulate megakaryocyte sialylation through type I interferon signaling, consequently influencing platelet production.
Article
Oncology
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltan Banki, Dorothee von Laer
Summary: This study examined the interaction of oncolytic viruses with dendritic cells in different species and subsets, showing varied infection, activation, and cytokine production patterns. Matured dendritic cells were less susceptible to VSV-GP infection, while VSV-dM51-GP induced maturation and inflammatory cytokine release. Different dendritic cell types exhibited distinct responses to VSV and VSV-GP variants, highlighting the importance of considering these differences in immunological mechanisms of oncolytic virotherapy.